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Found 3497 with Last Name = 'cosford' and Initial = 'nd'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109106(US8609852, 13)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109136(US8609852, 43)
Affinity DataKi:  0.650nM ΔG°:  -52.4kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50172117(2-Cyclohex-1-enylethynyl-pyridine | CHEMBL196643)
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109101(US8609852, 7)
Affinity DataKi:  0.700nM ΔG°:  -52.3kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109157(US8609852, 64)
Affinity DataKi:  0.800nM ΔG°:  -51.9kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50172136(4-Pyridin-2-ylethynyl-3,6-dihydro-2H-pyridine-1-ca...)
Affinity DataKi:  0.830nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109102(US8609852, 8)
Affinity DataKi:  0.900nM ΔG°:  -51.6kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109115(US8609852, 117 | US8609852, 34)
Affinity DataKi:  0.900nM ΔG°:  -51.6kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109121(US8609852, 28)
Affinity DataKi:  0.900nM ΔG°:  -51.6kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109120(US8609852, 27)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109099(US8609852, 5)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109115(US8609852, 117 | US8609852, 34)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50149792(5-(2-Methyl-thiazol-4-ylethynyl)-[3,3'']bipyridiny...)
Affinity DataKi:  1nMAssay Description:Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109182(US8609852, 91)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109176(US8609852, 85)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109105(US8609852, 12)
Affinity DataKi:  1.10nM ΔG°:  -51.1kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50172123(3-Chloro-5-(3-pyridin-2-ylethynyl-cyclohex-2-enylo...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109100(US8609852, 6)
Affinity DataKi:  1.20nM ΔG°:  -50.9kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109113(US8609852, 20)
Affinity DataKi:  1.40nM ΔG°:  -50.5kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50181753(3-[(2-methyl-4-thiazolyl)ethynyl]-5-vinylpyridine ...)
Affinity DataKi:  1.40nM ΔG°:  -50.5kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109153(US8609852, 60)
Affinity DataKi:  1.5nM ΔG°:  -50.4kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109151(US8609852, 58)
Affinity DataKi:  1.5nM ΔG°:  -50.4kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109147(US8609852, 54)
Affinity DataKi:  1.5nM ΔG°:  -50.4kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109114(US8609852, 21)
Affinity DataKi:  1.5nM ΔG°:  -50.4kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109194(US8609852, 103)
Affinity DataKi:  1.60nM ΔG°:  -50.2kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109116(US8609852, 23)
Affinity DataKi:  1.60nM ΔG°:  -50.2kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50154997(3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50172130(2-{[3-(pyridin-3-yloxy)cyclohex-1-en-1-yl]ethynyl}...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109096(US8609852, 2)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109137(US8609852, 44)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50149805(2-(Pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)pyr...)
Affinity DataKi:  2nMAssay Description:Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50149801(2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine | ...)
Affinity DataKi:  2nMAssay Description:Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109180(US8609852, 89)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109173(US8609852, 82)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109166(US8609852, 73)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109119(US8609852, 26)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50154997(3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109139(US8609852, 46)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109145(US8609852, 52)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109123(US8609852, 30)
Affinity DataKi:  2.30nM ΔG°:  -49.3kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109117(US8609852, 24)
Affinity DataKi:  2.60nM ΔG°:  -49.0kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109108(US8609852, 15)
Affinity DataKi:  2.60nM ΔG°:  -49.0kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109098(US8609852, 4)
Affinity DataKi:  2.60nM ΔG°:  -49.0kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109097(US8609852, 3)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109112(US8609852, 19)
Affinity DataKi:  2.80nM ΔG°:  -48.8kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109184(US8609852, 93)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109129(US8609852, 36)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM109169(US8609852, 76)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50123009(3-Methyl-5-(2-methyl-thiazol-4-ylethynyl)-pyridine...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50172119(2-[1-(4-Bromo-benzenesulfonyl)-1,2,3,6-tetrahydro-...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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