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Found 4455 with Last Name = 'crawford' and Initial = 't'
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277145((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277131((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataKi:  7.40nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277180(4-(1-(2-(5-chloro-1H-indol-3-yl)ethyl)piperidin-3-...)
Affinity DataKi:  10.4nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277146((+)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N...)
Affinity DataKi:  11.2nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277146((+)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N...)
Affinity DataKi:  11.2nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277130((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataKi:  21.3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277147(CHEMBL473903 | N-cyclopropyl-4-(1-(2-(5-fluoro-1H-...)
Affinity DataKi:  23.6nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277181(4-(1-(2-(5-chloro-2-methyl-1H-indol-3-yl)ethyl)pip...)
Affinity DataKi:  26.6nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277144((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277182(CHEMBL475694 | N-cyclopropyl-4-(1-(2-(7-fluoro-1H-...)
Affinity DataKi:  35.1nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277184(CHEMBL474282 | N-cyclopropyl-4-(1-(2-((S)-2,3-dihy...)
Affinity DataKi:  37.8nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277210(4-(1-(2-(benzo[b]thiophen-3-yl)ethyl)piperidin-3-y...)
Affinity DataKi:  38.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277212(4-(1-(1-(1H-indol-3-yl)propan-2-yl)piperidin-3-yl)...)
Affinity DataKi:  40.2nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277211(CHEMBL475090 | N-cyclopropyl-4-(1-(2-(2,3-dihydro-...)
Affinity DataKi:  42.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277183(CHEMBL514010 | N-cyclopropyl-4-(1-(2-(6-fluoro-1H-...)
Affinity DataKi:  64.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277252(4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-(2-...)
Affinity DataKi:  66.3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277129((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataKi:  75.3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277251(4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-(3-...)
Affinity DataKi:  78.3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277250(3-(4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)pyr...)
Affinity DataKi:  175nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277214(CHEMBL475092 | N-cyclopropyl-4-(1-(2-(thiazol-4-yl...)
Affinity DataKi:  780nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277213(2-(3-(2-(cyclopropylamino)pyrimidin-4-yl)piperidin...)
Affinity DataKi:  3.42E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277249(4-(1-(2-(1H-pyrazol-4-yl)ethyl)piperidin-3-yl)-N-c...)
Affinity DataKi:  4.45E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069868((2,5-Dimethoxy-benzyl)-((2S,3S)-2-phenyl-piperidin...)
Affinity DataIC50:  0.0900nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285009(3-{3-[(3R,5R)-1-(tert-Butylcarbamoyl-methyl)-5-cyc...)
Affinity DataIC50:  0.100nMAssay Description:Binding activity towards cholecystokinin-A (CCK-A) receptor in guinea pig pancreasMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285009(3-{3-[(3R,5R)-1-(tert-Butylcarbamoyl-methyl)-5-cyc...)
Affinity DataIC50:  0.100nMAssay Description:Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069863(CHEMBL329007 | N-{4-Methoxy-3-[((2S,3S)-2-phenyl-p...)
Affinity DataIC50:  0.110nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069870((2-Ethoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-2-ph...)
Affinity DataIC50:  0.140nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069864((5-Chloro-2-methoxy-benzyl)-((2S,3S)-2-phenyl-pipe...)
Affinity DataIC50:  0.140nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069865((2-Isopropoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-...)
Affinity DataIC50:  0.180nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50067935((2-Methoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-2-p...)
Affinity DataIC50:  0.190nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285019(CHEMBL294161 | N-tert-Butyl-2-((3R,5R)-5-cyclohexy...)
Affinity DataIC50:  0.220nMAssay Description:Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285011(CHEMBL294252 | N-tert-Butyl-2-{(3R,5R)-5-cyclohexy...)
Affinity DataIC50:  0.260nMAssay Description:Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEstrogen receptor beta(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  0.354nMAssay Description:Inhibition of estradiol binding to estrogen receptorMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069862((2-Difluoromethoxy-benzyl)-((2S,3S)-2-phenyl-piper...)
Affinity DataIC50:  0.410nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069867((2-Isopropoxy-benzyl)-((2S,3S)-2-phenyl-piperidin-...)
Affinity DataIC50:  0.460nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50037849(CHEMBL291458 | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-chl...)
Affinity DataIC50:  0.480nMAssay Description:Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50030232((S)-((S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  0.480nMAssay Description:Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50000041((+) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-a...)
Affinity DataIC50:  0.490nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50000040(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  0.520nMAssay Description:Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]-Bolton-Hunter substance p from human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069860((5-Dimethylamino-2-methoxy-benzyl)-((2S,3S)-2-phen...)
Affinity DataIC50:  0.560nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50037869(CHEMBL334100 | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-chl...)
Affinity DataIC50:  0.600nMAssay Description:In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]-BH-CCK-8 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285014(3-{3-[(3R,5R)-1-(tert-Butylcarbamoyl-methyl)-5-cyc...)
Affinity DataIC50:  0.600nMAssay Description:Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50001450((SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH...)
Affinity DataIC50:  0.610nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285010(3-{3-[(3R,5R)-1-(tert-Butylcarbamoyl-methyl)-8-met...)
Affinity DataIC50:  0.700nMAssay Description:Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50158623(CHEMBL3785440)
Affinity DataIC50:  0.700nMAssay Description:Binding affinity to His-tagged BRD4 bromodomain1 (unknown origin) incubated for 1 hr in presence of Europium Cryptate-labeled streptavidin by TR-FRET...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069869(((2S,3S)-2-Phenyl-piperidin-3-yl)-(2-trifluorometh...)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285012(CHEMBL301418 | N-tert-Butyl-2-((3R,5R)-8-methyl-2-...)
Affinity DataIC50:  0.810nMAssay Description:Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285018(CHEMBL59234 | N-tert-Butyl-2-((3R,5S)-5-cyclohexyl...)
Affinity DataIC50:  0.880nMAssay Description:Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285022(CHEMBL57642 | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-meth...)
Affinity DataIC50:  0.880nMAssay Description:Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails Article
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