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Found 223 with Last Name = 'cummings' and Initial = 'cg'
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM13307(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM13307(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM13311(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM31423(ethylenediamine scaffold, 4)
Affinity DataIC50:  1.20nMpH: 7.5 T: 2°CAssay Description:Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM13309(N-(2-{(4-bromophenyl)[(1-methyl-1H-imidazol-5-yl)m...)
Affinity DataIC50:  1.90nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM13308(N-benzyl-N-(2-{(4-bromophenyl)[(1-methyl-1H-imidaz...)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM13310(N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)m...)
Affinity DataIC50:  2.10nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM31424(ethylenediamine scaffold, 5)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM13315(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Affinity DataIC50:  4.5nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM31425(ethylenediamine scaffold, 7)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13315(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Affinity DataIC50:  7.5nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM13312(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[Biphenyl...)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM13313(N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...)
Affinity DataIC50:  8.90nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13313(N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13311(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Affinity DataIC50:  15.5nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13307(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...)
Affinity DataIC50:  25nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
LigandPNGBDBM50327976(CHEMBL215476 | N-benzyl-N-(2-((4-cyanophenyl)((1-m...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327983(1-methyl-1H-imidazole-4-sulfonic acid {2-[(4-cyano...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327977(CHEMBL379511 | N-benzyl-N-(2-((4-cyanophenyl)((1-m...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13313(N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13310(N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)m...)
Affinity DataIC50:  43nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327974(CHEMBL1258797 | N-Benzyl,N-{2-[(4-Cyanophenyl)-(3-...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327975(CHEMBL215475 | N-benzyl-N-(2-((4-cyanophenyl)((1-m...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13311(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327979(1-methyl-1H-imidazole-4-sulfonic acid allyl-{2-[(4...)
Affinity DataIC50:  54nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327990(1-methyl-1H-imidazole-4-sulfonic acid {2-[(4-cyano...)
Affinity DataIC50:  54nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM13314(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Affinity DataIC50:  55nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13307(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...)
Affinity DataIC50:  56nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
LigandPNGBDBM13307(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...)
Affinity DataIC50:  56nMpH: 7.7 T: 2°CAssay Description:In vitro inhibition assay of human PFT was done by measuring the incorporation of [3H] FPP (Amersham Biosciences, Piscataway, NJ) into wild type H-Ra...More data for this Ligand-Target Pair
LigandPNGBDBM13315(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134041(CHEMBL1256439)
Affinity DataIC50:  64nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327985(CHEMBL452319 | N-(2-((4-cyanophenyl)((1-methyl-1H-...)
Affinity DataIC50:  67nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327974(CHEMBL1258797 | N-Benzyl,N-{2-[(4-Cyanophenyl)-(3-...)
Affinity DataIC50:  70nMAssay Description:Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM31426(ethylenediamine scaffold, 10)
Affinity DataIC50:  70nMpH: 7.5 T: 2°CAssay Description:Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327982(1-methyl-1H-imidazole-4-sulfonic acid {2-[(4-cyano...)
Affinity DataIC50:  72nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327992(1-methyl-1H-imidazole-4-sulfonic acid (3-cyanobenz...)
Affinity DataIC50:  78nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13308(N-benzyl-N-(2-{(4-bromophenyl)[(1-methyl-1H-imidaz...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13309(N-(2-{(4-bromophenyl)[(1-methyl-1H-imidazol-5-yl)m...)
Affinity DataIC50:  83nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50133900(CHEMBL1258798)
Affinity DataIC50:  85nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327998(CHEMBL1258350 | N-(2-((4-cyano-2-fluorophenyl)((1-...)
Affinity DataIC50:  89nMAssay Description:Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327976(CHEMBL215476 | N-benzyl-N-(2-((4-cyanophenyl)((1-m...)
Affinity DataIC50:  90nMAssay Description:Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM13318(N-(4-cyanobenzyl)-N-(2-{(4-cyanophenyl)[(1-methyl-...)
Affinity DataIC50:  95nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13315(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Affinity DataIC50:  100nMAssay Description:Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50133905(CHEMBL1257648)
Affinity DataIC50:  110nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327980(1-methyl-1H-imidazole-4-sulfonic acid {2-[(4-cyano...)
Affinity DataIC50:  114nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13314(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31425(ethylenediamine scaffold, 7)
Affinity DataIC50:  160nMpH: 7.7 T: 2°CAssay Description:In vitro inhibition assay of human PFT was done by measuring the incorporation of [3H] FPP (Amersham Biosciences, Piscataway, NJ) into wild type H-Ra...More data for this Ligand-Target Pair
LigandPNGBDBM50327981(1-methyl-1H-imidazole-4-sulfonic acid (2-bromoally...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13314(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Affinity DataIC50:  180nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327993(1-methyl-1H-imidazole-4-sulfonic acid biphenyl-3-y...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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