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Found 319 with Last Name = 'deng' and Initial = 'sx'
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241831(CHEMBL4062273 | US10626113, Compound M | US1089975...)
Affinity DataIC50:  0.0560nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241840(CHEMBL4072903 | US10899756, Compound K)
Affinity DataIC50:  0.0590nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241832(CHEMBL4083986 | US10626113, Compound C | US1089975...)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50428976(CHEMBL2333219)
Affinity DataIC50:  0.277nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241842(CHEMBL4064315 | US10899756, Compound M)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of adenylate cyclase via Adenosine A1 receptor in rat fat cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241835(CHEMBL4092717 | US10899756, Compound AC)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50428975(CHEMBL2333220)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424629(CHEMBL2313193)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50242157(CHEMBL4070894 | US10626113, Compound B | US1089975...)
Affinity DataIC50:  0.590nMAssay Description:Concentration required to inhibit the activity of K+ stimulated gastric ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424594(CHEMBL2313183)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424631(CHEMBL2313191)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50428971(CHEMBL2333224)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424632(CHEMBL2313190)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50191859(1-adamantan-1-yl-3-[1-(2,2,2-trifluoro-acetyl)-pip...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424630(CHEMBL2313192)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241834(CHEMBL4065036 | US10626113, Compound J | US1089975...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50360348(CHEMBL1933651)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424601(CHEMBL2313176)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241837(CHEMBL4102913 | US10626113, Compound G | US1089975...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM25732(3-adamantan-1-yl-1-cyclohexylurea | CHEMBL242255 |...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424638(CHEMBL2313189)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241843(CHEMBL4102250 | US10899756, Compound N)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424596(CHEMBL2313181)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424611(CHEMBL2313166)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM25737(12-[(adamantan-1-ylcarbamoyl)amino]dodecanoic acid...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241839(CHEMBL4083346)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241841(CHEMBL4092040 | US10899756, Compound L)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50428972(CHEMBL2333223)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50428974(CHEMBL2333221)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424615(CHEMBL2313162)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50191878(1-(1-Acetyl-piperidin-4-ylmethyl)-3-adamantan-1-yl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of epoxide hydrolase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424616(CHEMBL2313161)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424635(CHEMBL2313186)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50360341(CHEMBL1933515)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424637(CHEMBL2313188)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424619(CHEMBL2313203)
Affinity DataIC50:  6nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241840(CHEMBL4072903 | US10899756, Compound K)
Affinity DataIC50:  6.60nMAssay Description:Concentration required to inhibit the activity of K+ stimulated gastric ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50360321(CHEMBL1933497)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424602(CHEMBL2313175)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424610(CHEMBL2313167)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50191854(CHEMBL436774 | N-(1-acetyl-piperidin-4-yl)-N'-(ada...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50360345(CHEMBL1933648)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50278163(CHEMBL469792 | N-cycloheptyl-1-(mesitylsulfonyl)pi...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of epoxide hydrolase (unknown origin)More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424597(CHEMBL2313180)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424628(CHEMBL2313194)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50424609(CHEMBL2313168)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50360358(CHEMBL1933661)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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