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Found 2029 with Last Name = 'ding' and Initial = 'z'
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi:  0.470nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294042(US10106557, Compound 8)
Affinity DataKi:  0.900nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi:  1.01nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294042(US10106557, Compound 8)
Affinity DataKi:  1.92nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi:  1.93nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi:  2.87nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294042(US10106557, Compound 8)
Affinity DataKi:  3.17nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294041(US10106557, Compound 7)
Affinity DataKi:  4.13nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi:  4.22nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294041(US10106557, Compound 7)
Affinity DataKi:  4.41nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi:  4.45nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294043(US10106557, Compound 30)
Affinity DataKi:  9.71nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387065(1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387065(1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387068(1-(4-Methoxyphenyl)-7-oxo-6-(2-oxo-[1,4′-bip...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387068(1-(4-Methoxyphenyl)-7-oxo-6-(2-oxo-[1,4′-bip...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387077(4-(4-(1-(4-(Difluoromethoxy)phenyl)-7-oxo-3-(trifl...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387077(4-(4-(1-(4-(Difluoromethoxy)phenyl)-7-oxo-3-(trifl...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387078(4-(4-(1-(6-Chloronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387078(4-(4-(1-(6-Chloronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387078(4-(4-(1-(6-Chloronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387080(4-(4-(1-(3-Aminobenzo[d]isoxazol-5-yl)-7-oxo-3-(tr...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387080(4-(4-(1-(3-Aminobenzo[d]isoxazol-5-yl)-7-oxo-3-(tr...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387080(4-(4-(1-(3-Aminobenzo[d]isoxazol-5-yl)-7-oxo-3-(tr...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387082(4-(4-(1-(3-Fluoro-4-methoxyphenyl)-7-oxo-3-(triflu...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387082(4-(4-(1-(3-Fluoro-4-methoxyphenyl)-7-oxo-3-(triflu...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387082(4-(4-(1-(3-Fluoro-4-methoxyphenyl)-7-oxo-3-(triflu...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387083(4-(4-(1-(3-Fluoronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387083(4-(4-(1-(3-Fluoronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387083(4-(4-(1-(3-Fluoronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387085(3-(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-3-(...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM19023(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM19023(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387049(4-(4-(1-(4-Methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387049(4-(4-(1-(4-Methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387049(4-(4-(1-(4-Methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387050(1-(4-Methoxyphenyl)-6-(2′-oxo-[1,1′-bi...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387050(1-(4-Methoxyphenyl)-6-(2′-oxo-[1,1′-bi...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387050(1-(4-Methoxyphenyl)-6-(2′-oxo-[1,1′-bi...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387054(1-(4-Methoxyphenyl)-6-(1-(2-oxopyrrolidin-1-yl)pip...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387054(1-(4-Methoxyphenyl)-6-(1-(2-oxopyrrolidin-1-yl)pip...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387054(1-(4-Methoxyphenyl)-6-(1-(2-oxopyrrolidin-1-yl)pip...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387055(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387055(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387056(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387057(N′-Cyano-1-(4-methoxyphenyl)-7-oxo-6-(2̸...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387057(N′-Cyano-1-(4-methoxyphenyl)-7-oxo-6-(2̸...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387058(1-(4-Methoxyphenyl)-7-oxo-6-(1-(3-oxomorpholino)pi...)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical

US Patent
LigandPNGBDBM387058(1-(4-Methoxyphenyl)-7-oxo-6-(1-(3-oxomorpholino)pi...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM387059(US9938272, Example 8a | US9938272, Example 8b)
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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