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Found 2294 with Last Name = 'doherty' and Initial = 'am'
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataKi:  0.0100nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368606(Sarafotoxin S6B)
Affinity DataKi:  0.0120nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368606(Sarafotoxin S6B)
Affinity DataKi:  0.0130nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataKi:  0.0150nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368605(CHEMBL1790178)
Affinity DataKi:  0.0160nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368607(CHEMBL1790180)
Affinity DataKi:  0.0210nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368605(CHEMBL1790178)
Affinity DataKi:  0.0230nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataKi:  0.0340nMAssay Description:Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368607(CHEMBL1790180)
Affinity DataKi:  0.0360nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368606(Sarafotoxin S6B)
Affinity DataKi:  0.0870nMAssay Description:Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072528((6S,8aS)-2-[3-(3,4-Dichloro-phenyl)-propionyl]-4-o...)
Affinity DataKi:  0.106nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataKi:  0.110nMAssay Description:Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368606(Sarafotoxin S6B)
Affinity DataKi:  0.240nMAssay Description:Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072536((6S,8aS)-2-(3-Naphthalen-1-yl-propionyl)-4-oxo-oct...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072524((6S,8aS)-4-Oxo-2-[3-(2-trifluoromethyl-phenyl)-pro...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072527((6S,8aS)-4-Oxo-2-(3-p-tolyl-propionyl)-octahydro-p...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072534((6S,8aS)-2-(3-Naphthalen-2-yl-propionyl)-4-oxo-oct...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072537((6S,8aS)-2-[3-(4-Methoxy-phenyl)-propionyl]-4-oxo-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072532((6S,8aS)-4-Oxo-2-(3-phenyl-propionyl)-octahydro-py...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072520((6S,8aS)-2-[3-(2-Fluoro-phenyl)-propionyl]-4-oxo-o...)
Affinity DataKi:  0.920nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072533((6S,8aS)-4-Oxo-2-(4-phenyl-butyryl)-octahydro-pyrr...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080924(CHEMBL83260 | N-[(S)-1-(1-Carbamimidoyl-piperidin-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368607(CHEMBL1790180)
Affinity DataKi:  2.5nMAssay Description:Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072530((6S,8aS)-4-Oxo-2-phenylacetyl-octahydro-pyrrolo[1,...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368607(CHEMBL1790180)
Affinity DataKi:  2.5nMAssay Description:Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072541((6S,8aS)-4-Oxo-2-(3-pyridin-2-yl-propionyl)-octahy...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072519((6S,8aS)-2-[(S)-2-Amino-3-(4-fluoro-phenyl)-propio...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50289562(CHEMBL3216390 | CHEMBL543774 | {(R)-1-Cyclohexylme...)
Affinity DataKi:  3nMAssay Description:Selective inhibition of thrombin in several in vitro and in vivo models of thrombosisMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080911(2-((S)-4-Benzyl-2-naphthalen-2-ylmethyl-3,6-dioxo-...)
Affinity DataKi:  3.5nMAssay Description:Inhibitory concentration of the compound required against thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072529((6S,8aS)-2-((S)-2-Hydroxy-3-phenyl-propionyl)-4-ox...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072535((6S,8aS)-4-Oxo-2-(3-phenoxy-propionyl)-octahydro-p...)
Affinity DataKi:  5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080920(CHEMBL313769 | N-[(S)-1-(1-Carbamimidoyl-piperidin...)
Affinity DataKi:  8nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080895(CHEMBL311198 | N-[(S)-1-(1-Carbamimidoyl-piperidin...)
Affinity DataKi:  14nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50289562(CHEMBL3216390 | CHEMBL543774 | {(R)-1-Cyclohexylme...)
Affinity DataKi:  15nMAssay Description:Inhibition of thrombin was evaulatedMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072521((6S,8aS)-4-Oxo-2-(2-phenoxy-acetyl)-octahydro-pyrr...)
Affinity DataKi:  16nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072538((6S,8aS)-4-Oxo-2-(3-phenyl-propyl)-octahydro-pyrro...)
Affinity DataKi:  17nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072526((6S,8aS)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propi...)
Affinity DataKi:  18nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072526((6S,8aS)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propi...)
Affinity DataKi:  18nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080916(CHEMBL84084 | N-[(S)-1-(1-Carbamimidoyl-piperidin-...)
Affinity DataKi:  20nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072539((6S,8aS)-2-(3-Cyclohexyl-propionyl)-4-oxo-octahydr...)
Affinity DataKi:  24nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080908(2-[(S)-2-Benzyl-3,6-dioxo-4-(3-phenyl-propyl)-pipe...)
Affinity DataKi:  24nMAssay Description:Binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072540((6S,8aS)-2-Benzoyl-4-oxo-octahydro-pyrrolo[1,2-a]p...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080895(CHEMBL311198 | N-[(S)-1-(1-Carbamimidoyl-piperidin...)
Affinity DataKi:  30nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080915(2-((R)-2-Benzyl-4-butyl-3,6-dioxo-piperazin-1-yl)-...)
Affinity DataKi:  32nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072525((6S,8aS)-4-Oxo-2-(1,2,3,4-tetrahydro-isoquinoline-...)
Affinity DataKi:  32nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080903(CHEMBL83549 | N-[(S)-1-(1-Carbamimidoyl-piperidin-...)
Affinity DataKi:  40nMAssay Description:Binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080905(CHEMBL83681 | N-[(S)-1-(1-Carbamimidoyl-piperidin-...)
Affinity DataKi:  43nMAssay Description:Binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50289562(CHEMBL3216390 | CHEMBL543774 | {(R)-1-Cyclohexylme...)
Affinity DataKi:  45nMAssay Description:Selective inhibition of thrombin in several in vitro and in vivo models of thrombosisMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072518((6S,8aS)-6-[4-Guanidino-1-(thiazole-2-carbonyl)-bu...)
Affinity DataKi:  50nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080930(2-[(R)-2-Benzyl-3,6-dioxo-4-(3-phenyl-propyl)-pipe...)
Affinity DataKi:  55nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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