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Found 139 with Last Name = 'dorwin' and Initial = 'sa'
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15956(Aminopyridine-Based Inhibitor 18b | N-(4-Amino-5-c...)
Affinity DataKi:  1nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataKi:  2nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15976(Aminopyridine-Based Inhibitor 35 | N-(4-Amino-5-ch...)
Affinity DataKi:  3nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15939(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Affinity DataKi:  3nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataKi:  4nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15956(Aminopyridine-Based Inhibitor 18b | N-(4-Amino-5-c...)
Affinity DataKi:  4nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15939(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Affinity DataKi:  9nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15976(Aminopyridine-Based Inhibitor 35 | N-(4-Amino-5-ch...)
Affinity DataKi:  13nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15956(Aminopyridine-Based Inhibitor 18b | N-(4-Amino-5-c...)
Affinity DataKi:  18nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataKi:  52nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM81731(HSP90 Inhibitor, 5)
Affinity DataKi:  60nM ΔG°:  -41.2kJ/molepH: 7.5 T: 2°CAssay Description:HSP90 inhibitors identified using Fluorescence resonance energy transfer assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15976(Aminopyridine-Based Inhibitor 35 | N-(4-Amino-5-ch...)
Affinity DataKi:  61nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15939(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Affinity DataKi:  72nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM81730(HSP90 Inhibitor, 4)
Affinity DataKi:  170nM ΔG°:  -38.6kJ/molepH: 7.5 T: 2°CAssay Description:HSP90 inhibitors identified using Fluorescence resonance energy transfer assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15907(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Affinity DataKi:  190nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM81729(HSP90 Inhibitor, 1 | hsp90_125)
Affinity DataKi:  320nM ΔG°:  -37.1kJ/molepH: 7.5 T: 2°CAssay Description:HSP90 inhibitors identified using Fluorescence resonance energy transfer assay.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15907(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Affinity DataKi:  440nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15907(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Affinity DataKi:  520nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15968(Aminopyridine-Based Inhibitor 24 | N-(4-Amino-5-cy...)
Affinity DataKi:  550nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM81732(HSP90 Inhibitor, 6)
Affinity DataKi:  1.90E+3nM ΔG°:  -32.7kJ/molepH: 7.5 T: 2°CAssay Description:HSP90 inhibitors identified using Fluorescence resonance energy transfer assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15968(Aminopyridine-Based Inhibitor 24 | N-(4-Amino-5-cy...)
Affinity DataKi:  1.90E+3nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15968(Aminopyridine-Based Inhibitor 24 | N-(4-Amino-5-cy...)
Affinity DataKi:  3.30E+3nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM81733(HSP90 Inhibitor, 7)
Affinity DataKi:  4.00E+3nM ΔG°:  -30.8kJ/molepH: 7.5 T: 2°CAssay Description:HSP90 inhibitors identified using Fluorescence resonance energy transfer assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50270588(4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-AMINE | CH...)
Affinity DataKi:  1.80E+4nM ΔG°:  -27.1kJ/molepH: 7.5 T: 2°CAssay Description:HSP90 inhibitors identified using Fluorescence resonance energy transfer assay.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15956(Aminopyridine-Based Inhibitor 18b | N-(4-Amino-5-c...)
Affinity DataIC50:  14nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15938(2-(4-Acetylamino-2,5-dimethoxyphenyl)-N-(4-amino-5...)
Affinity DataIC50:  26nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15938(2-(4-Acetylamino-2,5-dimethoxyphenyl)-N-(4-amino-5...)
Affinity DataIC50:  35nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15976(Aminopyridine-Based Inhibitor 35 | N-(4-Amino-5-ch...)
Affinity DataIC50:  36nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15939(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Affinity DataIC50:  38nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataIC50:  45nMpH: 7.2 T: 2°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15956(Aminopyridine-Based Inhibitor 18b | N-(4-Amino-5-c...)
Affinity DataIC50:  64nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15941(Aminopyridine-Based Inhibitor 6u | N-(4-Amino-5-cy...)
Affinity DataIC50:  69nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15952(1-[(4-Amino-5-cyano-6-ethoxypyridin-2-ylcarbamoyl)...)
Affinity DataIC50:  69nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15976(Aminopyridine-Based Inhibitor 35 | N-(4-Amino-5-ch...)
Affinity DataIC50:  70nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15962(Aminopyridine-Based Inhibitor 20a | N-[4-Amino-5-c...)
Affinity DataIC50:  74nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15940(Aminopyridine-Based Inhibitor 6t | N-(4-Amino-5-cy...)
Affinity DataIC50:  77nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15953(1-[(4-Amino-5-cyano-6-ethoxypyridin-2ylcarbamoyl)m...)
Affinity DataIC50:  87nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15941(Aminopyridine-Based Inhibitor 6u | N-(4-Amino-5-cy...)
Affinity DataIC50:  100nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15963(Aminopyridine-Based Inhibitor 20b | N-[4-Amino-5-c...)
Affinity DataIC50:  110nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15933(Aminopyridine-Based Inhibitor 6l | N-(4-Amino-5-cy...)
Affinity DataIC50:  120nMpH: 7.2 T: 2°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15953(1-[(4-Amino-5-cyano-6-ethoxypyridin-2ylcarbamoyl)m...)
Affinity DataIC50:  130nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15939(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Affinity DataIC50:  150nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15940(Aminopyridine-Based Inhibitor 6t | N-(4-Amino-5-cy...)
Affinity DataIC50:  160nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15948(Aminopyridine-Based Inhibitor 28d | N-(4-Amino-5-c...)
Affinity DataIC50:  160nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataIC50:  160nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15952(1-[(4-Amino-5-cyano-6-ethoxypyridin-2-ylcarbamoyl)...)
Affinity DataIC50:  180nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15935(Aminopyridine-Based Inhibitor 6n | N-(4-Amino-5-cy...)
Affinity DataIC50:  180nMpH: 7.2 T: 2°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15932(Aminopyridine-Based Inhibitor 6k | N-(4-Amino-5-cy...)
Affinity DataIC50:  190nMpH: 7.2 T: 2°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15934(Aminopyridine-Based Inhibitor 6m | N-(4-Amino-5-cy...)
Affinity DataIC50:  210nMpH: 7.2 T: 2°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15962(Aminopyridine-Based Inhibitor 20a | N-[4-Amino-5-c...)
Affinity DataIC50:  240nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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