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Found 4524 with Last Name = 'du' and Initial = 'h'
TargetTrypsin(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50533536(CHEMBL4483694)
Affinity DataKi:  0.160nMAssay Description:Inhibition of trypsin (unknown origin) using Bz-FVRpNA as substrate incubated for 30 mins measured for 7 mins by morrison plot analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180206((2S,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50163020((1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-chlo...)
Affinity DataKi:  0.290nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM21221((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...)
Affinity DataKi:  0.330nMAssay Description:Inhibition of [125I]-AB-MECA binding to rat Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataKi:  0.350nM ΔG°:  -54.0kJ/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50163025((1S,2R,3S,4R,5S)-4-(6-(3-bromobenzylamino)-2-chlor...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180197((2S,3S,4R,5R)-5-(2-chloro-6-(3-iodobenzylamino)-9H...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180219((2-chloropurin-9-yl)-3,4-dihydroxytetrahydrothiphe...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM25400((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]R-PIA or [3H]CGS 21680 from human adenosine A1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataKi:  0.450nM ΔG°:  -53.3kJ/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50179182((2R,3R,4S,5R)-2-(6-(bicyclo[2.2.1]heptan-7-ylamino...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]R-PIA or [3H]CGS 21680 from human adenosine A1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50163029(1N-methyl-4-[2-chloro-6-(5-iodo-2-methoxybenzylami...)
Affinity DataKi:  0.580nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180204((2S,3S,4R,5R)-5-(2-chloro-6-(cyclopropylamino)-9H-...)
Affinity DataKi:  0.670nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50163031((1S,2R,3S,4R,5S)-4-(2-chloro-6-(2,2-diphenylethyla...)
Affinity DataKi:  0.690nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Chick)
University of Illinois At Chicago

Curated by PDSP Ki Database
LigandPNGBDBM50006730((R)-2-Hydroxymethyl-5-[6-(1-methyl-2-phenyl-ethyla...)
Affinity DataKi:  0.720nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50163025((1S,2R,3S,4R,5S)-4-(6-(3-bromobenzylamino)-2-chlor...)
Affinity DataKi:  0.760nMAssay Description:Inhibition of [125I]-AB-MECA binding to rat Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.830nMAssay Description:Displacement of [3H]R-PIA or [3H]CGS 21680 from human adenosine A1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50163019(1N-methyl-4-[2-chloro-6-(2-chloro-5-iodobenzylamin...)
Affinity DataKi:  0.830nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataKi:  0.840nM ΔG°:  -51.8kJ/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50163010((2R,3S,4R,5R)-2-Hydroxymethyl-5-[6-(2-phenyl-cyclo...)
Affinity DataKi:  0.860nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180209((2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H...)
Affinity DataKi:  0.890nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50481609(CHEMBL610504)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataKi:  0.910nM ΔG°:  -51.6kJ/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50163020((1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-chlo...)
Affinity DataKi:  1nMAssay Description:Inhibition of [125I]-AB-MECA binding to rat Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50100418((1S,2R,3S,4R,5S)-4-(6-(3-iodobenzylamino)-2-chloro...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of [125I]-AB-MECA binding to rat Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180199((2S,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of [125I]-AB-MECA binding to rat Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Chick)
University of Illinois At Chicago

Curated by PDSP Ki Database
LigandPNGBDBM50006730((R)-2-Hydroxymethyl-5-[6-(1-methyl-2-phenyl-ethyla...)
Affinity DataKi:  1.13nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50163018((2R,3R,4S,5R)-2-[6-(5-Chloro-2-methoxy-benzylamino...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50199969(2-(4-cyclopentylmethyl-1,2,3-triazol-1-yl)-N6-meth...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]AB-MECA from human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM21221((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50199967(2-azido-N6-(5-chloro-2-methoxybenzyl)-9-(beta-D-ri...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]AB-MECA from human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50100418((1S,2R,3S,4R,5S)-4-(6-(3-iodobenzylamino)-2-chloro...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50163016((1S,2R,3S,4R,5S)-4-(6-(5-chloro-2-methoxybenzylami...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  1.5nM ΔG°:  -50.4kJ/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180207((2S,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin...)
Affinity DataKi:  1.63nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Chick)
University of Illinois At Chicago

Curated by PDSP Ki Database
LigandPNGBDBM50009552(2-[6-Amino-2-(2-morpholin-4-yl-ethylamino)-purin-9...)
Affinity DataKi:  1.66nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM86192(CAS_197801-88-0 | CHEMBL2165203 | SN003)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to CRFR1 by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50395823(CHEMBL2165205)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to CRFR1 by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50152162(CHEMBL188844 | CHEMBL2165204 | [3-(6-Dimethylamino...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to CRFR1 by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50088421((2R,3R,4S,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-p...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50199977(9-(5-ethylcarbamoyl-beta-D-ribofuranosyl)-N6-methy...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]AB-MECA from human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50088428((1R,2R,3S,4R,5S)-4-[2-Chloro-6-(3-iodo-benzylamino...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50180210((2S,3S,4R,5R)-5-(2-chloro-6-(cyclopentylamino)-9H-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]R-PIA from human adenosine A1 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50395822(CHEMBL1762817)
Affinity DataKi:  2nMAssay Description:Binding affinity to CRFR1 by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50199971(9-(5-ethylcarbamoyl-beta-D-ribofuranosyl)-N6-methy...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [125I]AB-MECA from human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180198((2S,3S,4R,5R)-5-[2-chloro-6-(2-methyl-benzylamino)...)
Affinity DataKi:  2.18nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50100416((1S,2R,3S,4R,5S)-4-(2-Chloro-6-methylamino-purin-9...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity of ligand at human adenosine receptors expressed in CHO cell. More data for this Ligand-Target Pair
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