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Found 118 with Last Name = 'eskildsen' and Initial = 'j'
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187877((S)-1-{2-[3-(3-fluoro-phenylsulfanyl)-biphenyl-4-y...)
Affinity DataIC50:  59nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445041(CHEMBL3098768 | US10195186, Example 48 | US9682967...)
Affinity DataIC50:  100nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187875(2-(methyl(2-(2-(phenylthio)phenoxy)ethyl)amino)ace...)
Affinity DataIC50:  160nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187888((S)-1-{2-[3-(3-fluoro-phenylsulfanyl)-4'-methoxy-b...)
Affinity DataIC50:  160nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445042(CHEMBL3098767 | US10195186, Example 7 | US9682967,...)
Affinity DataIC50:  170nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187869((S)-1-{2-[3-(3-fluoro-phenylsulfanyl)-3'-methoxy-b...)
Affinity DataIC50:  300nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445054(CHEMBL3098745 | US10195186, Example 1 | US9682967,...)
Affinity DataIC50:  330nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataIC50:  360nMAssay Description:Displacement of [3H]-neurotensin from human sortilin incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintillation proxi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187882((S)-1-(2-(2-(3-chlorophenylthio)phenoxy)ethyl)pyrr...)
Affinity DataIC50:  380nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187874((S)-1-(2-(4-chloro-2-(3-fluorophenylthio)phenoxy)e...)
Affinity DataIC50:  400nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445044(CHEMBL3098765 | US10195186, Example 36 | US9682967...)
Affinity DataIC50:  490nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187872((2S)-1-(2-(2-(3-fluorophenylthio)-4-(thiophen-3-yl...)
Affinity DataIC50:  520nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187890((S)-1-(2-(5-chloro-2-(3-fluorophenylthio)phenoxy)e...)
Affinity DataIC50:  600nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445058(CHEMBL3098741 | US10195186, Example 2 | US9682967,...)
Affinity DataIC50:  710nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445051(CHEMBL3098752 | US10195186, Example 5 | US9682967,...)
Affinity DataIC50:  830nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187889((S)-1-{2-[4-(3-fluoro-phenylsulfanyl)-biphenyl-3-y...)
Affinity DataIC50:  950nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445055(CHEMBL3098744 | US10195186, Example 45 | US9682967...)
Affinity DataIC50:  1.10E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187868((S)-1-(2-(3-chloro-2-(3-fluorophenylthio)phenoxy)e...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445043(CHEMBL3098766 | US10195186, Example 39 | US9682967...)
Affinity DataIC50:  1.30E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187881((S)-1-{2-[4'-chloro-3-(3-fluoro-phenylsulfanyl)-bi...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445057(CHEMBL3098742 | US10195186, Example 4 | US9682967,...)
Affinity DataIC50:  1.40E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445047(CHEMBL3098760 | US10195186, Example 22 | US9682967...)
Affinity DataIC50:  1.60E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445053(CHEMBL3098746)
Affinity DataIC50:  1.70E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445045(CHEMBL3098764 | US10195186, Example 25 | US9682967...)
Affinity DataIC50:  1.80E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445046(CHEMBL3098761 | US10195186, Example 24 | US9682967...)
Affinity DataIC50:  2.40E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445050(CHEMBL3098753 | US10195186, Example 15 | US9682967...)
Affinity DataIC50:  3.40E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445048(CHEMBL3098759 | US10195186, Example 21 | US9682967...)
Affinity DataIC50:  3.60E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187886(2-((2-(2-(3-chlorophenylthio)phenoxy)ethyl)(methyl...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445039(CHEMBL3098769)
Affinity DataIC50:  4.00E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187873(2-((2-(2-(3-fluorophenylthio)phenoxy)ethyl)(methyl...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445049(CHEMBL3098758)
Affinity DataIC50:  5.20E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445056(CHEMBL3098743 | US10195186, Example 3 | US9682967,...)
Affinity DataIC50:  6.40E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187879(2-((2-(2-(3-chlorophenylthio)phenoxy)ethyl)(ethyl)...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187871(2-((2-(2-(4-chlorophenylthio)phenoxy)ethyl)(methyl...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187863((S)-2-((1-(2-(3-fluorophenylthio)phenoxy)propan-2-...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445040(CHEMBL3098751)
Affinity DataIC50:  9.10E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187866(2-((2-(2-(4-tert-butylphenylthio)phenoxy)ethyl)(me...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187864(2-((1-(2-(3-fluorophenylthio)phenoxy)butan-2-yl)(m...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187870((R)-2-((1-(2-(3-fluorophenylthio)phenoxy)propan-2-...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445052(CHEMBL3098748)
Affinity DataIC50:  1.20E+4nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187883(2-((2-(2-(4-fluorophenylthio)phenoxy)ethyl)(methyl...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187885(2-((1-(2-(3-fluorophenylthio)phenoxy)-3-methylbuta...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187884((S)-1-(2-(2-chloro-6-(3-fluorophenylthio)phenoxy)e...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187878((R)-1-(2-(2-(3-chlorophenylthio)phenoxy)ethyl)pyrr...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187867(2-((2-(2-(3-chlorophenylthio)phenoxy)ethyl)(methyl...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187865(2-((2-(2-(4-methoxyphenylthio)phenoxy)ethyl)(methy...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187876(2-(methyl(2-(2-(p-tolylthio)phenoxy)ethyl)amino)ac...)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187880(2-((2-(2-(3-chlorophenylthio)phenoxy)ethyl)(ethyl)...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50187887(2-((2-(2-(4-acetamidophenylthio)phenoxy)ethyl)(met...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1b transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Acadia Pharmaceuticals

US Patent
LigandPNGBDBM193784(US9670209, Compound 302 1-((R)-3-((1R,3R,5S)-3-(cy...)
Affinity DataEC50:  1.30nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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