TargetDihydrofolate reductase(Homo sapiens (Human))
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Affinity DataKi: 0.000340nMAssay Description:Inhibition of human DHFR by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibitory constant against thymidylate synthase from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibitory constant against thymidylate synthase from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibitory constant against thymidylate synthase from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibitory constant against human thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 4.10nMAssay Description:Inhibitory constant against human thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 8.5nMAssay Description:Inhibitory constant against human thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 9.40nMAssay Description:Inhibitory constant against thymidylate synthase from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibitory constant against human thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibitory constant against human thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of human thymidylate synthase expressed in Escherichia coli incubated for 1 hr by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Inhibitory constant against thymidylate synthase from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 30nM ΔG°: -42.2kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 60nM ΔG°: -40.5kJ/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 60nM ΔG°: -40.5kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
Affinity DataKi: 60nM ΔG°: -40.5kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
Affinity DataKi: 78nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 80nM ΔG°: -39.8kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
Affinity DataKi: 80nMAssay Description:Apparent inhibition constant against Escherichia coli AmpC beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Inhibition of human dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Competitive inhibition of human dihydrofolate reductase by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Inhibition of Escherichia coli thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 210nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 240nM ΔG°: -37.2kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
Affinity DataKi: 270nMAssay Description:Competitive inhibition of human thymidylate synthase by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 300nM ΔG°: -36.6kJ/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Apparent inhibition constant against Escherichia coli AmpC beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of Escherichia coli thymidylate synthase AMore data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of human thymidylate synthase AMore data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of human thymidylate synthase AMore data for this Ligand-Target Pair
Affinity DataKi: 310nMAssay Description:Inhibition of Pneumocystis carinii thymidylate synthase using MTHF and dUMP as substratesMore data for this Ligand-Target Pair
Affinity DataKi: 390nMAssay Description:Inhibition of Lactobacillus casei thymidylate synthase using MTHF and dUMP as substratesMore data for this Ligand-Target Pair
Affinity DataKi: 390nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 450nMAssay Description:Apparent inhibition constant against Escherichia coli AmpC beta-lactamaseMore data for this Ligand-Target Pair