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Found 362 with Last Name = 'ferris' and Initial = 'r'
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM4685((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.0000150nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataKi:  0.0000570nMAssay Description:Inhibition of HIV1 protease by fluorescent peptide substrate based assayMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.00147nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50479982(Aptivus | CHEBI:63628 | Tipranavir | U-140690 | US...)
Affinity DataKi:  0.00800nMAssay Description:Inhibition of HIV1 protease by fluorescent peptide substrate based assayMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataKi:  0.0360nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50556532(CHEMBL4753891)
Affinity DataKi:  0.790nMAssay Description:Displacement of [3H]-CP55,940 from human CB1R expressed in CHO-K1 cell membranes assessed as inhibition constant incubated for 2 hrs by liquid scinti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50601131(CHEMBL5193398)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-CP55,940 from human CB2R expressed in CHO-K1 cell membranes assessed as inhibition constant incubated for 2 hrs by liquid scinti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50601132(CHEMBL5204176)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]-CP55,940 from human CB2R expressed in CHO-K1 cell membranes assessed as inhibition constant incubated for 2 hrs by liquid scinti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50072775(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]-CP55,940 from human CB1R expressed in CHO-K1 cell membranes assessed as inhibition constant incubated for 2 hrs by liquid scinti...More data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50556532(CHEMBL4753891)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-CP55,940 from human CB2R expressed in CHO-K1 cell membranes assessed as inhibition constant incubated for 2 hrs by liquid scinti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50562160(CHEMBL4757403)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of human recombinant MAGL using varying concentration of 4-nitrophenylacetate as substrate incubated for 30 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50570253(CHEMBL4467500)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]-CP55,940 from human CB2R expressed in CHO-K1 cell membranes assessed as inhibition constant incubated for 2 hrs by liquid scinti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50562158(CHEMBL4747585)
Affinity DataKi:  27nMAssay Description:Competitive inhibition of human recombinant MAGL using varying concentration of 4-nitrophenylacetate as substrate incubated for 30 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50562161(CHEMBL4755606)
Affinity DataKi:  30nMAssay Description:Competitive inhibition of human recombinant MAGL using varying concentration of 4-nitrophenylacetate as substrate incubated for 30 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50072775(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-CP55,940 from human CB2R expressed in CHO-K1 cell membranes assessed as inhibition constant incubated for 2 hrs by liquid scinti...More data for this Ligand-Target Pair
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50562159(CHEMBL4798508)
Affinity DataKi:  37nMAssay Description:Competitive inhibition of human recombinant MAGL using varying concentration of 4-nitrophenylacetate as substrate incubated for 30 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50601132(CHEMBL5204176)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-CP55,940 from human CB1R expressed in CHO-K1 cell membranes assessed as inhibition constant incubated for 2 hrs by liquid scinti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50570253(CHEMBL4467500)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-CP55,940 from human CB1R expressed in CHO-K1 cell membranes assessed as inhibition constant incubated for 2 hrs by liquid scinti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50601131(CHEMBL5193398)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-CP55,940 from human CB1R expressed in CHO-K1 cell membranes assessed as inhibition constant incubated for 2 hrs by liquid scinti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418490(CHEMBL1784385)
Affinity DataIC50:  0.355nMAssay Description:Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50331659(CHEMBL1288663 | N-tert-butyl-4-chloro-5-(4-(2-(4-(...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  0.75nMAssay Description:Inhibitory concentration against wild-type reverse transcriptase of HIV-1More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50257737(CHEMBL444497 | methyl 2-(4-fluorophenyl)-2-(4-(2-(...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 (unknown origin) expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412735(CHEMBL454251)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]MIP-1beta from human CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50331659(CHEMBL1288663 | N-tert-butyl-4-chloro-5-(4-(2-(4-(...)
Affinity DataIC50:  1.70nMAssay Description:Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50257690((E)-methyl N-cyano-4-(2-(3-(2-methyl-1H-benzo[d]im...)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 (unknown origin) expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50331658(CHEMBL1288924 | N-tert-butyl-5-(4-(2-(4-(1-butyl-3...)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50483553(CHEBI:76007 | Dolutegravir Sodium | GSK1349572 | G...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of strand transfer activity of Human immunodeficiency virus 1 Integrase using [3H]labeled target DNA as substrate after 45 mins by scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50257691((E)-isopropyl N-cyano-4-(2-(3-(2-methyl-1H-benzo[d...)
Affinity DataIC50:  3nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 (unknown origin) expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1803(2-Amino-6-arylthiobenzonitrile deriv. 3w | 2-amino...)
Affinity DataIC50:  3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50257734(2-(2,3-dimethylphenyl)-2-(4-(2-(3-(2-methyl-1H-ben...)
Affinity DataIC50:  3nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 (unknown origin) expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50257641(1-(8-(2-(1-(furan-2-ylmethyl)-4-phenylpiperidin-4-...)
Affinity DataIC50:  3nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 (unknown origin) expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM25351(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of Human immunodeficiency virus 1 integrase by strand transfer scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50331651(CHEMBL1288917 | N-allyl-N-(1-(2-(1-(5-(N-tert-buty...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50480673(Isentress | Isentress hd | MK-0518 | MK-0518 POTAS...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of strand transfer activity of Human immunodeficiency virus 1 Integrase using [3H]labeled target DNA as substrate after 45 mins by scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50331646(5-(4-(2-(4-(1-allyl-3-(4-cyanobenzyl)ureido)piperi...)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50331646(5-(4-(2-(4-(1-allyl-3-(4-cyanobenzyl)ureido)piperi...)
Affinity DataIC50:  3.90nMAssay Description:Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50257642(CHEMBL524050 | N-isopropyl-4-(2-(3-(2-methyl-1H-be...)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 (unknown origin) expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50257731(2-(4-fluorophenyl)-2-(4-(3-fluorophenyl)-4-(2-(3-(...)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 (unknown origin) expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50331639(4-cyanobenzyl allyl(1-(2-(1-(5-(N-tert-butylsulfam...)
Affinity DataIC50:  4.5nMAssay Description:Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50331638(4-(methylsulfonyl)benzyl allyl(1-(2-(1-(5-(N-tert-...)
Affinity DataIC50:  4.5nMAssay Description:Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1804(2-Amino-6-arylthiobenzonitrile deriv. 3x | 2-amino...)
Affinity DataIC50:  5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50257736(CHEMBL506273 | methyl 2-(4-(2-(3-(2-methyl-1H-benz...)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 (unknown origin) expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50257728((E)-N-((4-(2-(3-(2-methyl-1H-benzo[d]imidazol-1-yl...)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 (unknown origin) expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50257733(2-(2,6-dimethylphenyl)-2-(4-(2-(3-(2-methyl-1H-ben...)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 (unknown origin) expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412762(CHEMBL444938)
Affinity DataIC50:  5.01nMAssay Description:Displacement of [125I]MIP-1beta from human CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418505(CHEMBL1784481)
Affinity DataIC50:  5.01nMAssay Description:Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412739(CHEMBL503033)
Affinity DataIC50:  5.01nMAssay Description:Displacement of [125I]MIP-1beta from human CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412738(CHEMBL445772)
Affinity DataIC50:  5.25nMAssay Description:Displacement of [125I]MIP-1beta from human CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50257644(CHEMBL471149 | N-cyclohexyl-4-(2-(3-(2-methyl-1H-b...)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 (unknown origin) expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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