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Found 1355 with Last Name = 'fink' and Initial = 'c'
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50495103(CHEMBL3105243)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]WIN35428 from human DAT after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50495101(CHEMBL1945251)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]Nisoxetine from human SERT after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50495101(CHEMBL1945251)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]WIN35428 from human DAT after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50495103(CHEMBL3105243)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]Nisoxetine from human SERT after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM22166(3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...)
Affinity DataKi:  6.30nMAssay Description:Binding affinity to DAT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50296782((1R,2S,3S,5S)-methyl 8-((E)-3-iodoallyl)-3-p-tolyl...)
Affinity DataKi:  17nMAssay Description:Binding affinity to DAT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50495101(CHEMBL1945251)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]Imipramin from human NET after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50283607(7-(2-Mercaptomethyl-3-phenyl-propionylamino)-hepta...)
Affinity DataKi:  26nMAssay Description:In vitro inhibition against neutral endopeptidase 24.11 (NEP) in rat kidney cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM22166(3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...)
Affinity DataKi:  29nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM22166(3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...)
Affinity DataKi:  33nMAssay Description:Binding affinity to NET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50495102(CHEMBL3105242)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]WIN35428 from human DAT after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50495102(CHEMBL3105242)
Affinity DataKi:  71nMAssay Description:Displacement of [3H]Nisoxetine from human SERT after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50495103(CHEMBL3105243)
Affinity DataKi:  153nMAssay Description:Displacement of [3H]Imipramin from human NET after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50296782((1R,2S,3S,5S)-methyl 8-((E)-3-iodoallyl)-3-p-tolyl...)
Affinity DataKi:  500nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50495102(CHEMBL3105242)
Affinity DataKi:  785nMAssay Description:Displacement of [3H]Imipramin from human NET after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50296782((1R,2S,3S,5S)-methyl 8-((E)-3-iodoallyl)-3-p-tolyl...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to NET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107813((S)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107808(6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic ...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM105283(US8575203, I-50)
Affinity DataIC50:  1nMAssay Description:The activity of the compounds according to the invention on the kinase PDK1 which inhibits the signal transduction pathway is determined in an in vit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581660(CHEMBL1714813)
Affinity DataIC50:  1nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM105308(US8575203, I-75)
Affinity DataIC50:  1nMAssay Description:The activity of the compounds according to the invention on the kinase PDK1 which inhibits the signal transduction pathway is determined in an in vit...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM139819(US8895581, III-5)
Affinity DataIC50:  1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM139828(US8895581, III-14)
Affinity DataIC50:  1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM139837(US8895581, III-23)
Affinity DataIC50:  1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM139840(US8895581, III-26)
Affinity DataIC50:  1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM139845(US8895581, III-31)
Affinity DataIC50:  1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM139765(US8895581, I-1)
Affinity DataIC50:  1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM105303(US8575203, I-70)
Affinity DataIC50:  1nMAssay Description:The activity of the compounds according to the invention on the kinase PDK1 which inhibits the signal transduction pathway is determined in an in vit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049]()
Boehringer Ingelheim International

US Patent
LigandPNGBDBM472582(US10829487, Example I-61)
Affinity DataIC50:  1nMAssay Description:Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049]()
Boehringer Ingelheim International

US Patent
LigandPNGBDBM472647(US10829487, Example I-130)
Affinity DataIC50:  1nMAssay Description:Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM139798(US8895581, II-19)
Affinity DataIC50:  1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM139796(US8895581, II-17)
Affinity DataIC50:  1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM139785(US8895581, II-6)
Affinity DataIC50:  1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107774(4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carboxy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107809(CHEMBL143284 | {5-[(4,6-Dimethyl-4'-trifluoromethy...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017129((S)-1-((S)-2-((R)-1-ethoxy-1-oxo-4-phenylbutan-2-y...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibition against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107797(4'-Fluoro-6-methyl-biphenyl-2-carboxylic acid (2-b...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048318((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...)
Affinity DataIC50:  1.20nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107790(4'-Trifluoromethyl-biphenyl-2-carboxylic acid (2-b...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107772(4'-Fluoro-6-methyl-biphenyl-2-carboxylic acid [2-(...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048312((S)-3-(4-Hydroxy-phenyl)-2-{[1-((S)-2-mercapto-3-m...)
Affinity DataIC50:  1.5nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048320((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...)
Affinity DataIC50:  1.5nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107804(CHEMBL142975 | {2-[(6-Methyl-4'-trifluoromethyl-bi...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107803(6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic ...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107787((S)-6-methyl-N-(2-(pyridin-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107775(4-{5-[(6-Methyl-4'-trifluoromethyl-biphenyl-2-carb...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107810(6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic ...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048304((S)-3-(4-Fluoro-phenyl)-2-{[1-((S)-2-mercapto-3-me...)
Affinity DataIC50:  1.80nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107812(CHEMBL142928 | {5-[(6,4'-Bis-trifluoromethyl-biphe...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107798(CHEMBL139992 | {5-[(4'-Trifluoromethyl-biphenyl-2-...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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