TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]WIN35428 from human DAT after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]Nisoxetine from human SERT after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Displacement of [3H]WIN35428 from human DAT after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 2.40nMAssay Description:Displacement of [3H]Nisoxetine from human SERT after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 6.30nMAssay Description:Binding affinity to DAT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Binding affinity to DAT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [3H]Imipramin from human NET after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:In vitro inhibition against neutral endopeptidase 24.11 (NEP) in rat kidney cortex membraneMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 29nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 33nMAssay Description:Binding affinity to NET (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 37nMAssay Description:Displacement of [3H]WIN35428 from human DAT after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 71nMAssay Description:Displacement of [3H]Nisoxetine from human SERT after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 153nMAssay Description:Displacement of [3H]Imipramin from human NET after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 500nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: 785nMAssay Description:Displacement of [3H]Imipramin from human NET after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical University Of Vienna
Curated by ChEMBL
Medical University Of Vienna
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to NET (unknown origin)More data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMAssay Description:The activity of the compounds according to the invention on the kinase PDK1 which inhibits the signal transduction pathway is determined in an in vit...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMAssay Description:The activity of the compounds according to the invention on the kinase PDK1 which inhibits the signal transduction pathway is determined in an in vit...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMAssay Description:The activity of the compounds according to the invention on the kinase PDK1 which inhibits the signal transduction pathway is determined in an in vit...More data for this Ligand-Target Pair
TargetGTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049]()
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMAssay Description:Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...More data for this Ligand-Target Pair
TargetGTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049]()
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMAssay Description:Compounds are diluted to a final start concentration of 100 μM and are tested in duplicate. Assay-ready plates (ARPs) are generated using an Acc...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 1nMpH: 7.5Assay Description:Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...More data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibition against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Novartis Institute For Biomedical Reasearch
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair