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Found 74 with Last Name = 'folmer' and Initial = 'rh'
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca Global Structural Chemistry

Curated by ChEMBL
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Affinity DataKi:  5.80E+3nMAssay Description:Inhibition of Helicobacter pylori glutamate racemaseMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21625(2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole | 2-phen...)
Affinity DataIC50:  21nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca Global Structural Chemistry

Curated by ChEMBL
LigandPNGBDBM50215445(5-(2-((6-chloroquinolin-4-yl)methyl)-7-(cyclopropy...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Helicobacter pylori glutamate racemaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21627(N-[4-methyl-3-({3-[(4-methylpiperazin-1-yl)methyl]...)
Affinity DataIC50:  75nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226448((6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21624(4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]a...)
Affinity DataIC50:  138nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226454(2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-d...)
Affinity DataIC50:  200nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  380nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226448((6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-...)
Affinity DataIC50:  470nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  590nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226454(2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-d...)
Affinity DataIC50:  640nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  670nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21626(3-phenyl-5-(1H-pyrazol-3-yl)-1,2-oxazole | 3-pheny...)
Affinity DataIC50:  920nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21616(4-{[4-(2-methoxyphenyl)-1,3-thiazol-2-yl]amino}ben...)
Affinity DataIC50:  994nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca Global Structural Chemistry

Curated by ChEMBL
LigandPNGBDBM50215444(5-METHYL-7-(2-METHYLPROPYL)-2-(NAPHTHALEN-1-YLMETH...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of Helicobacter pylori glutamate racemaseMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21628(Pyridine-3-carboxylate | methyl 6-(3-pyridin-4-yl-...)
Affinity DataIC50:  1.50E+3nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226455(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3,6-dimeth...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226455(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3,6-dimeth...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226447(2-amino-3,6-dimethyl-6-phenyl-5,6-dihydro-3H-pyrim...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226440(2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-di...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226447(2-amino-3,6-dimethyl-6-phenyl-5,6-dihydro-3H-pyrim...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226447(2-amino-3,6-dimethyl-6-phenyl-5,6-dihydro-3H-pyrim...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21618(3-(4-methoxyphenyl)-5H-indeno[1,2-c]pyridazin-5-on...)
Affinity DataIC50:  3.80E+3nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21629(3-(4-methylphenyl)-5H-indeno[1,2-c]pyridazin-5-one...)
Affinity DataIC50:  3.80E+3nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226453(2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226453(2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226453(2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226440(2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-di...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226440(2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-di...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21613(2-[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enamido]benz...)
Affinity DataIC50:  1.16E+4nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21620(2-bromo-1-(4-methoxynaphthalen-1-yl)ethan-1-one | ...)
Affinity DataIC50:  1.24E+4nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226443(6-(2-(1H-indol-6-yl)ethyl)-2-amino-3-methylpyrimid...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21623(2,4-dichloro-6-(1H-pyrazol-5-yl)phenol | Phenol, 1...)
Affinity DataIC50:  1.74E+4nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226457(6-(3-(pyridin-3-yl)phenethyl)-2-amino-3-methylpyri...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21621(3-(3,5-dimethyl-1H-pyrrol-2-yl)-1H-pyrazole | Pyra...)
Affinity DataIC50:  2.64E+4nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226441(2-amino-3-methyl-6-(2-(naphthalen-2-yl)ethyl)pyrim...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226441(2-amino-3-methyl-6-(2-(naphthalen-2-yl)ethyl)pyrim...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226449(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3-methylpy...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226438((S)-5-((S)-1-carboxy-2-phenylethylamino)-4-((S)-2-...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16047((4S)-4-[(2S)-2-[(2R,4S,5S)-5-[(2S)-2-[(2S)-2-[(4S)...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226449(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3-methylpy...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21617(4-(3,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-5-amin...)
Affinity DataIC50:  3.30E+4nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226456(2-amino-3,6-dimethyl-6-phenethyl-5,6-dihydropyrimi...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21622(2-methyl-5-(1H-pyrazol-5-yl)pyridine | Pyridine, 1...)
Affinity DataIC50:  3.47E+4nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226450((S)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226441(2-amino-3-methyl-6-(2-(naphthalen-2-yl)ethyl)pyrim...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21619(Phenylpyridazine-3-carboxylate, 7 | ethyl 5-methox...)
Affinity DataIC50:  4.50E+4nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226443(6-(2-(1H-indol-6-yl)ethyl)-2-amino-3-methylpyrimid...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226444(6-(3-(1H-pyrrol-2-yl)phenethyl)-2-amino-3-methylpy...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226443(6-(2-(1H-indol-6-yl)ethyl)-2-amino-3-methylpyrimid...)
Affinity DataIC50:  7.70E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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