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Found 796 with Last Name = 'fraser' and Initial = 'c'
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM86231(ATR | ATROPINE | Atropine,(-) | CAS_51-55-8 | CHEM...)
Affinity DataKi:  0.290nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206229(3-(9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hex...)
Affinity DataKi:  0.700nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50089369(CHEMBL3577959)
Affinity DataKi:  0.700nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50209802(CHEMBL438490 | N,N-dimethyl-3-phenoxy-3-(4-(3-(pip...)
Affinity DataKi:  0.720nMAssay Description:Binding affinity at human histamine H3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198598(CHEMBL396945 | N-ethyl-3-(4-(4-methoxyphenyl)-2-me...)
Affinity DataKi:  0.730nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50184767(CHEMBL3824089 | US10294227, Code 506)
Affinity DataKi:  0.800nMAssay Description:Competitive inhibition of C-terminal His-tagged full length human SRC expressed in insect cells preincubated for 20 mins using poly[Glu,Tyr]4:1 as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206218(6-(4-methoxyphenyl)-9-(3-(piperidin-1-yl)propoxy)-...)
Affinity DataKi:  0.800nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206222(6-phenyl-9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,1...)
Affinity DataKi:  0.900nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198609(7-(3-(azetidin-1-yl)propoxy)-4-(4-methoxyphenyl)-2...)
Affinity DataKi:  1nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50321465((6-(3-chlorophenoxy)pyridin-3-yl)(4-cyclobutyl-1,4...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50089374(CHEMBL3577954)
Affinity DataKi:  1nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50089375(CHEMBL3577953)
Affinity DataKi:  1nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206228(6-(3-chlorophenyl)-9-(3-(piperidin-1-yl)propoxy)-1...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206235(4-(9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hex...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206227(6-(2-methoxyphenyl)-9-(3-(piperidin-1-yl)propoxy)-...)
Affinity DataKi:  1.30nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206229(3-(9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hex...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]citalopram from rat brain SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50346208((1-isopropylpiperidin-4-yl)(4-(piperidin-1-ylmethy...)
Affinity DataKi:  1.30nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50089372(CHEMBL3577956)
Affinity DataKi:  1.30nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206225(6-(4-nitrophenyl)-9-(3-(piperidin-1-yl)propoxy)-1,...)
Affinity DataKi:  1.30nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198585(7-(3-(4-isopropylpiperazin-1-yl)propoxy)-4-(4-meth...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50321467((4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenox...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198599(1-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahy...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50089370(CHEMBL3577958)
Affinity DataKi:  1.5nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50321503((5-(3,4-dichlorophenoxy)pyridin-2-yl)(4-isopropyl-...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198607(7-(3-(4-ethylpiperazin-1-yl)propoxy)-4-(4-methoxyp...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206233(CHEMBL238951 | N,N-dimethyl-4-(9-(3-(piperidin-1-y...)
Affinity DataKi:  1.60nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-4-(4-methoxy...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206236(6-(4-fluorophenyl)-9-(3-(piperidin-1-yl)propoxy)-1...)
Affinity DataKi:  1.70nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206217(4-(9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hex...)
Affinity DataKi:  1.70nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206221(6-(3-methoxyphenyl)-9-(3-(piperidin-1-yl)propoxy)-...)
Affinity DataKi:  1.70nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198596(CHEMBL427845 | N,N-diethyl-3-(4-(4-methoxyphenyl)-...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198585(7-(3-(4-isopropylpiperazin-1-yl)propoxy)-4-(4-meth...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50321466(3-(5-(4-cyclobutyl-1,4-diazepane-1-carbonyl)pyridi...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-4-(4-methoxy...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206232(6-(3-ethynylphenyl)-9-(3-(piperidin-1-yl)propoxy)-...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198590(4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198607(7-(3-(4-ethylpiperazin-1-yl)propoxy)-4-(4-methoxyp...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198602((1-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrah...)
Affinity DataKi:  2nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198604(7-(3-(3,3-difluoroazetidin-1-yl)propoxy)-4-(4-meth...)
Affinity DataKi:  2nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198590(4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)...)
Affinity DataKi:  2nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198590(4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)...)
Affinity DataKi:  2nMAssay Description:Binding affinity at human histamine H3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206219(9-(3-(piperidin-1-yl)propoxy)-6-(3-(trifluoromethy...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206224(9-(3-(piperidin-1-yl)propoxy)-6-p-tolyl-1,2,3,5,6,...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206222(6-phenyl-9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,1...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]citalopram from rat brain SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50089368(CHEMBL3577960)
Affinity DataKi:  2nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206218(6-(4-methoxyphenyl)-9-(3-(piperidin-1-yl)propoxy)-...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]citalopram from rat brain SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50198596(CHEMBL427845 | N,N-diethyl-3-(4-(4-methoxyphenyl)-...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM254203(US10112937, Example 88 | US10150765, Example 88 | ...)
Affinity DataKi:  2.20nMAssay Description:Antagonist activity at recombinant rat P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50206237(6-(4-chlorophenyl)-9-(3-(piperidin-1-yl)propoxy)-1...)
Affinity DataKi:  2.20nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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