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Found 2316 with Last Name = 'fraser' and Initial = 'g'
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50359261(CHEMBL1923617)
Affinity DataKi:  0.350nMAssay Description:Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMotilin receptor(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50002694(MOTILIN)
Affinity DataKi:  0.360nMAssay Description:Displacement of [125I]motilin from human MOTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50359239(CHEMBL1923629)
Affinity DataKi:  0.380nMAssay Description:Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50079412((NKB)Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 |...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [125I][MePhe7]NKB from human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50359250(CHEMBL1923640)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-SB222200 from recombinant human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to human NK3 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081194(CHEMBL3422009 | US10544150, Compound 156)
Affinity DataKi:  2nMAssay Description:Binding affinity to human recombinant NK3R by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081194(CHEMBL3422009 | US10544150, Compound 156)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-SB222200 from recombinant human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081396(CHEMBL3422014)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-SB222200 from recombinant human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50359252(CHEMBL1923642)
Affinity DataKi:  2.60nMAssay Description:Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081196(CHEMBL3422015 | US10065961, Compound 13 | US106832...)
Affinity DataKi:  3nMAssay Description:NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251923(BDBM272562 | US10683295, Compound 25 | US10941151,...)
Affinity DataKi:  3nMAssay Description:NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081196(CHEMBL3422015 | US10065961, Compound 13 | US106832...)
Affinity DataKi:  3nMAssay Description:NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251923(BDBM272562 | US10683295, Compound 25 | US10941151,...)
Affinity DataKi:  3nMAssay Description:NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081196(CHEMBL3422015 | US10065961, Compound 13 | US106832...)
Affinity DataKi:  3nMAssay Description:The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251923(BDBM272562 | US10683295, Compound 25 | US10941151,...)
Affinity DataKi:  3nMpH: 7.4Assay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251923(BDBM272562 | US10683295, Compound 25 | US10941151,...)
Affinity DataKi:  3nMAssay Description:The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081196(CHEMBL3422015 | US10065961, Compound 13 | US106832...)
Affinity DataKi:  3nMpH: 7.4Assay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081198(CHEMBL3422018 | US10065961, Compound 24 | US947581...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]-SB222200 from recombinant human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081198(CHEMBL3422018 | US10065961, Compound 24 | US947581...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to human recombinant NK3R by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081196(CHEMBL3422015 | US10065961, Compound 13 | US106832...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]-SB222200 from recombinant human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50052524((S)-N-((S)-1-{[(S)-1-({[(S)-1-((S)-1-Carbamoyl-3-m...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [125I][MePhe7]NKB from human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Macaca mulatta)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081194(CHEMBL3422009 | US10544150, Compound 156)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-SB222200 from monkey NK3R after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251909(US10065961, Compound 7 | US10683295, Compound 7 | ...)
Affinity DataKi:  4nMAssay Description:NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251909(US10065961, Compound 7 | US10683295, Compound 7 | ...)
Affinity DataKi:  4nMAssay Description:The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251909(US10065961, Compound 7 | US10683295, Compound 7 | ...)
Affinity DataKi:  4nMAssay Description:NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251909(US10065961, Compound 7 | US10683295, Compound 7 | ...)
Affinity DataKi:  4nMpH: 7.4Assay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50359259(CHEMBL1923610)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMotilin receptor(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50214268((5R,8R,11S)-8-(propan-2-yl)-11-(pyrrolidin-1-ylmet...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [125I]-motilin from human motilin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50359238(CHEMBL1923628)
Affinity DataKi:  4.80nMAssay Description:Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50359238(CHEMBL1923628)
Affinity DataKi:  4.80nMAssay Description:Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251907(US10065961, Compound 5 | US10683295, Compound 5 | ...)
Affinity DataKi:  5nMAssay Description:NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251907(US10065961, Compound 5 | US10683295, Compound 5 | ...)
Affinity DataKi:  5nMAssay Description:NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251907(US10065961, Compound 5 | US10683295, Compound 5 | ...)
Affinity DataKi:  5nMpH: 7.4Assay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50359237(CHEMBL1923627)
Affinity DataKi:  5nMAssay Description:Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251907(US10065961, Compound 5 | US10683295, Compound 5 | ...)
Affinity DataKi:  5nMAssay Description:The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081399(CHEMBL3422016 | US10065961, Compound 19 | US106832...)
Affinity DataKi:  6nMAssay Description:NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081399(CHEMBL3422016 | US10065961, Compound 19 | US106832...)
Affinity DataKi:  6nMAssay Description:NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081399(CHEMBL3422016 | US10065961, Compound 19 | US106832...)
Affinity DataKi:  6nMAssay Description:The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMotilin receptor(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50214266((5R,8R,11S)-11-[(methylamino)methyl]-8-(propan-2-y...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]-motilin from human motilin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081399(CHEMBL3422016 | US10065961, Compound 19 | US106832...)
Affinity DataKi:  6nMpH: 7.4Assay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMotilin receptor(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50214270(1-{[(5R,8R,11S)-5-[(4-chlorophenyl)methyl]-6,9,12-...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]-motilin from human motilin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMotilin receptor(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50214264(1-{[(5R,8R,11S)-6,9,12-trioxo-8-(propan-2-yl)-5-{[...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]-motilin from human motilin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50359233(CHEMBL1923623)
Affinity DataKi:  6.20nMAssay Description:Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Macaca mulatta)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081196(CHEMBL3422015 | US10065961, Compound 13 | US106832...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-SB222200 from monkey NK3R after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081399(CHEMBL3422016 | US10065961, Compound 19 | US106832...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-SB222200 from recombinant human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Macaca mulatta)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50081198(CHEMBL3422018 | US10065961, Compound 24 | US947581...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-SB222200 from monkey NK3R after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tranzyme Pharma

Curated by ChEMBL
LigandPNGBDBM50359282(CHEMBL1923609)
Affinity DataKi:  6.40nMAssay Description:Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM251918(US10065961, Compound 17 | US10683295, Compound 17 ...)
Affinity DataKi:  7nMAssay Description:NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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