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Found 114 with Last Name = 'fraser' and Initial = 'hl'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50161957(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(p...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50161957(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(p...)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of human EGFR in presence of 1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209886((2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-fluor...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209878((2E)-N-[4-({4-[(3-chlorobenzyl)oxy]-3,6-dioxocyclo...)
Affinity DataIC50:  12.2nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209879((2E)-N-(4-{[4-(benzyloxy)-3,6-dioxocyclohexa-1,4-d...)
Affinity DataIC50:  18.7nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32447(Benzo[c][2,7]naphthyridine, 39)
Affinity DataIC50:  24nMAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209883((2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-methy...)
Affinity DataIC50:  24.9nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32435(Benzo[c][2,7]naphthyridine, 28)
Affinity DataIC50:  26nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM21(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)
Affinity DataIC50:  27.3nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32450(Benzo[c][2,7]naphthyridine, 42)
Affinity DataIC50:  30nMAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...)
Affinity DataIC50:  34.9nMAssay Description:Inhibition of human EGFR in presence of 1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32430(Benzo[c][2,7]naphthyridine, 24)
Affinity DataIC50:  35nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209878((2E)-N-[4-({4-[(3-chlorobenzyl)oxy]-3,6-dioxocyclo...)
Affinity DataIC50:  35.6nMAssay Description:Inhibition of human EGFR in presence of 1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32433(Benzo[c][2,7]naphthyridine, 14)
Affinity DataIC50:  43nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209886((2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-fluor...)
Affinity DataIC50:  43.1nMAssay Description:Inhibition of human EGFR in presence of 1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209877(2-(3-fluorobenzyloxy)-5-(6-methoxy-7-(2-methoxyeth...)
Affinity DataIC50:  46.1nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32444(Benzo[c][2,7]naphthyridine, 36)
Affinity DataIC50:  47nMAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209884((2E)-4-(dimethylamino)-N-(4-{[3,6-dioxo-4-(2-thien...)
Affinity DataIC50:  47.5nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209882(2-(3-methoxybenzyloxy)-5-(6-methoxy-7-(2-methoxyet...)
Affinity DataIC50:  50.2nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32449(Benzo[c][2,7]naphthyridine, 41)
Affinity DataIC50:  51nMAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209888(2-(benzyloxy)-5-(6-methoxy-7-(2-methoxyethoxy)quin...)
Affinity DataIC50:  53.7nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32436(Benzo[c][2,7]naphthyridine, 29)
Affinity DataIC50:  57nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32437(Benzo[c][2,7]naphthyridine, 30)
Affinity DataIC50:  65nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32427(Benzo[c][2,7]naphthyridine, 21)
Affinity DataIC50:  66nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32445(Benzo[c][2,7]naphthyridine, 37)
Affinity DataIC50:  67nMAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32422(Benzo[c][2,7]naphthyridine, 9)
Affinity DataIC50:  70nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32431(Benzo[c][2,7]naphthyridine, 25)
Affinity DataIC50:  74nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32441(Benzo[c][2,7]naphthyridine, 33)
Affinity DataIC50:  74nMAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209884((2E)-4-(dimethylamino)-N-(4-{[3,6-dioxo-4-(2-thien...)
Affinity DataIC50:  76.2nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209878((2E)-N-[4-({4-[(3-chlorobenzyl)oxy]-3,6-dioxocyclo...)
Affinity DataIC50:  80.2nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209885((2E)-4-(dimethylamino)-N-(4-{[3,6-dioxo-4-(pyridin...)
Affinity DataIC50:  90.8nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32448(Benzo[c][2,7]naphthyridine, 40)
Affinity DataIC50:  91nMAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50: >100nMAssay Description:Inhibition of human EGFR in presence of 1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32425(Benzo[c][2,7]naphthyridine, 12)
Affinity DataIC50:  100nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32428(Benzo[c][2,7]naphthyridine, 22)
Affinity DataIC50: >100nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209879((2E)-N-(4-{[4-(benzyloxy)-3,6-dioxocyclohexa-1,4-d...)
Affinity DataIC50:  102nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209875((2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-metho...)
Affinity DataIC50:  107nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32423(Benzo[c][2,7]naphthyridine, 10)
Affinity DataIC50:  108nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209881((2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[2-fluoro...)
Affinity DataIC50:  109nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209880((2E)-N-[4-({4-[(3,4-difluorobenzyl)oxy]-3,6-dioxoc...)
Affinity DataIC50:  112nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM21(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)
Affinity DataIC50:  112nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209886((2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-fluor...)
Affinity DataIC50:  113nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209885((2E)-4-(dimethylamino)-N-(4-{[3,6-dioxo-4-(pyridin...)
Affinity DataIC50:  135nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209888(2-(benzyloxy)-5-(6-methoxy-7-(2-methoxyethoxy)quin...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human VEGFR2 in presence of 1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32446(Benzo[c][2,7]naphthyridine, 38)
Affinity DataIC50:  142nMAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32434(Benzo[c][2,7]naphthyridine, 27)
Affinity DataIC50:  144nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1 [48-359](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM32432(Benzo[c][2,7]naphthyridine, 26)
Affinity DataIC50:  146nMpH: 7.4 T: 2°CAssay Description:A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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