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maximum 50k data
Found 611 with Last Name = 'fu' and Initial = 'q'
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science And Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50442257(CHEMBL2028192)
Affinity DataKi:  30nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin using FA-Fly-Leu-NH2 as substrate at pH 7.5 after 15 mins by Henderson plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science And Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50442257(CHEMBL2028192)
Affinity DataKi:  32nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science And Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50442256(CHEMBL2442111)
Affinity DataKi:  280nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin using FA-Fly-Leu-NH2 as substrate at pH 7.5 after 15 mins by Henderson plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50583309(CHEMBL4204851)
Affinity DataIC50:  0.0340nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of TRKC (unknown origin) using TK as substrate in presence of ATP incubated for 40 mins by HTRF KinEASE assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454734(US10730868, Ex. No. 2)
Affinity DataIC50:  0.460nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454806(US10730868, Ex. No. 73)
Affinity DataIC50:  0.5nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454739(US10730868, Ex. No. 7)
Affinity DataIC50:  0.670nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDeoxycytidine kinase(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311570(2-(6-(4-(4-aminopyrimidin-2-yloxy)piperidin-1-yl)-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human dCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454801(US10730868, Ex. No. 68 | US10730868, Ex. No. 71)
Affinity DataIC50:  0.75nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454835((cis)-4,4-difluoro-2-((5-fluoro-2-(3-m ethoxy-6-me...)
Affinity DataIC50:  0.75nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454738(US10730868, Ex. No. 6)
Affinity DataIC50:  0.760nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454747((1R, 2S)-4,4-difluoro-2-((5-fluoro-2-(3-methoxy-6-...)
Affinity DataIC50:  0.770nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454799(US10730868, Ex. No. 66 | US10730868, Ex. No. 72)
Affinity DataIC50:  0.790nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454735(US10730868, Ex. No. 3)
Affinity DataIC50:  0.820nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454809(US10730868, Ex. No. 76 | US10730868, Ex. No. 79)
Affinity DataIC50:  0.900nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454793(US10730868, Ex. No. 61 | US10730868, Ex. No. 67 | ...)
Affinity DataIC50:  0.990nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDeoxycytidine kinase(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311564(2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperid...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human dCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxycytidine kinase(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311568(3-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperid...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human dCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454751((1R,2S)-4,4-difluoro-2-((5-fluoro-2-(2-methoxy-7-m...)
Affinity DataIC50:  1nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454763(US10730868, Ex. No. 31)
Affinity DataIC50:  1.10nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454799(US10730868, Ex. No. 66 | US10730868, Ex. No. 72)
Affinity DataIC50:  1.10nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454815(US10730868, Ex. No. 82)
Affinity DataIC50:  1.10nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454802(US10730868, Ex. No. 69)
Affinity DataIC50:  1.20nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454740(US10730868, Ex. No. 8)
Affinity DataIC50:  1.20nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454833((cis)-4,4-difluoro-2-((5-fluoro-2-(2-methoxy-7-met...)
Affinity DataIC50:  1.30nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454757(US10730868, Ex. No. 25)
Affinity DataIC50:  1.30nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454793(US10730868, Ex. No. 61 | US10730868, Ex. No. 67 | ...)
Affinity DataIC50:  1.30nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454748((1R,2S)-2-((2-(6-chloro-3-methoxyquinolin-8-vi)-5-...)
Affinity DataIC50:  1.30nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454790(US10730868, Ex. No. 58 | cis-2-((5-fluoro-2-(2-met...)
Affinity DataIC50:  1.40nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454787(US10730868, Ex. No. 55 | US10730868, Ex. No. 59 | ...)
Affinity DataIC50:  1.40nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454801(US10730868, Ex. No. 68 | US10730868, Ex. No. 71)
Affinity DataIC50:  1.60nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454733((1R,2S)-4,4-difluoro-2-((5-fluoro-2-(2-methoxy-7-m...)
Affinity DataIC50:  1.60nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454766(US10730868, Ex. No. 34)
Affinity DataIC50:  1.60nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDeoxycytidine kinase(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311609(CHEMBL1080444 | N-((1S,3S)-3-(4-amino-5-fluoro-2-o...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human deoxycytidine kinase by lysate filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454745(US10730868, Ex. No. 13 | US10730868, Ex. No. 20)
Affinity DataIC50:  1.80nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454788(US10730868, Ex. No. 56)
Affinity DataIC50:  1.80nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454736(US10730868, Ex. No. 4)
Affinity DataIC50:  1.90nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454797(US10730868, Ex. No. 64)
Affinity DataIC50:  1.90nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454778(US10730868, Ex. No. 46 | rac-cis-2-((2-(7-cyano-2-...)
Affinity DataIC50:  2nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDeoxycytidine kinase(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311569(2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperid...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human dCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454777(US10730868, Ex. No. 45 | rac-cis-2-((2-(7-cyano-2-...)
Affinity DataIC50:  2.20nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454746(US10730868, Ex. No. 14)
Affinity DataIC50:  2.40nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454780((1R,2S)-2-((5-fluoro-2-(2-methoxy-7-methylquinoxal...)
Affinity DataIC50:  2.40nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454768(US10730868, Ex. No. 36)
Affinity DataIC50:  2.40nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454754((1R,2S)-2-((5-fluoro-2-(2-methoxy-7-methylquinoxal...)
Affinity DataIC50:  2.40nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454837(US10730868, Ex. No. 104 | rac-cis-5-((5-fluoro-2-(...)
Affinity DataIC50:  2.40nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454767(US10730868, Ex. No. 35 | US10730868, Ex. No. 37)
Affinity DataIC50:  2.5nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454784((1R,2S)-2-((5-fluoro-2-(2-methoxy-7-methylquinoxal...)
Affinity DataIC50:  2.5nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM454764(US10730868, Ex. No. 32)
Affinity DataIC50:  2.60nMAssay Description:FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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