Compile Data Set for Download or QSAR
maximum 50k data
Found 143 with Last Name = 'fuchs' and Initial = 'j'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505841(CHEMBL4532034 | US11174245, # I-018)
Affinity DataIC50:  12nMAssay Description:Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrphan methyltransferase M.SssI(Spiroplasma monobiae strain MQ-1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50059989((1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-phenyl)-he...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Spiroplasma sp. MQ-1 M.SssIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrphan methyltransferase M.SssI(Spiroplasma monobiae strain MQ-1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50067040(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Spiroplasma sp. MQ-1 M.SssIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrphan methyltransferase M.SssI(Spiroplasma monobiae strain MQ-1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50163744((1E,4Z,6E)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Spiroplasma sp. MQ-1 M.SssIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  75nMAssay Description:Inhibition of NFkappa p65 in nuclear extract of human HeLa cells assessed as blockade of NFkappa p65 binding to biotinylated-consesus sequence by ELI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Mus musculus)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  81nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
LigandPNGBDBM50593519(CHEMBL5204252)
Affinity DataIC50:  96nMAssay Description:Inhibition of chymotrypsin-like activity of human erythrocytes 20S proteasome using Suc-LLVY-AMC as substrate and measured by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  120nMAssay Description:Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  136nMAssay Description:Inhibition of biotinylated-TAR-RNA binding to HIV1 His6-tagged integrase expressed in Escherichia coli BL21(DE3) preincubated for 2 hrs followed by R...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  150nMAssay Description:Inhibition of LEDGF/p75-dependant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  150nMAssay Description:Inhibition of LEDGF/p75 binding to HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
The Ohio State University

LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  170nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
The Ohio State University

LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  180nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Mus musculus)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505838(CHEMBL4537790)
Affinity DataIC50:  190nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50508823(CHEMBL4544303)
Affinity DataIC50:  210nMAssay Description:Inhibition of biotinylated-TAR-RNA binding to HIV1 His6-tagged integrase expressed in Escherichia coli BL21(DE3) preincubated for 2 hrs followed by R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505836(CHEMBL4434788 | US11174245, # I-064)
Affinity DataIC50:  267nMAssay Description:Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Mus musculus)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505845(CHEMBL4566193)
Affinity DataIC50:  270nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505843(CHEMBL4449589 | US11174245, # I-235)
Affinity DataIC50:  353nMAssay Description:Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
The Ohio State University

LigandPNGBDBM50011132(ALLINI-1 | CHEMBL3259891)
Affinity DataIC50:  400nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50508823(CHEMBL4544303)
Affinity DataIC50:  480nMAssay Description:Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505839(CHEMBL4525935 | US11174245, # I-001)
Affinity DataIC50:  519nMAssay Description:Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50513777(CHEMBL4534212)
Affinity DataIC50:  600nMAssay Description:Inhibition of Papaya papain using Z-FR-MCA as substrate by spectrofluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Mus musculus)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505841(CHEMBL4532034 | US11174245, # I-018)
Affinity DataIC50:  700nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50508831(CHEMBL4450048)
Affinity DataIC50:  810nMAssay Description:Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50508826(CHEMBL4476045)
Affinity DataIC50:  830nMAssay Description:Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [A1275T](Human immunodeficiency virus 1 (Virus))
The Ohio State University

LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  890nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535069(CHEMBL4448648)
Affinity DataIC50:  900nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase A128T mutant expressed in Escherichia coli BL21(DE3) cells assessed as red...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
The Ohio State University

LigandPNGBDBM50011132(ALLINI-1 | CHEMBL3259891)
Affinity DataIC50:  910nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50508833(CHEMBL4557062)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Mus musculus)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505846(CHEMBL4562138)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50508829(CHEMBL4572060)
Affinity DataIC50:  1.14E+3nMAssay Description:Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Bangalore University

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50508825(CHEMBL4527313)
Affinity DataIC50:  1.22E+3nMAssay Description:Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50011132(ALLINI-1 | CHEMBL3259891)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of re...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Mus musculus)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505842(CHEMBL4519157)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA helicase IV(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50177710((3-acetylamino-5-oxo-5,11-dihydro-10-thia-dibenzo[...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of ATPase activity of Helicase4 from Escherichia coli in presence of ATP (5x Km(ATP)) and dT25 (5x KDNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50513779(CHEMBL4441556)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of trypsin (unknown origin) using Z-FR-MCA as substrate by spectrofluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Bangalore University

Curated by ChEMBL
LigandPNGBDBM50106343(CHEMBL3596280)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Bangalore University

Curated by ChEMBL
LigandPNGBDBM50106341(CHEMBL3596282)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505837(CHEMBL4591327)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Mus musculus)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505840(CHEMBL4550104)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Bangalore University

Curated by ChEMBL
LigandPNGBDBM50106342(CHEMBL3596281)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505844(CHEMBL4444231)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50346334(1,3,7-trihydroxy-2,4-diisoprenylxanthone | CHEMBL1...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of NFkappa p65 in nuclear extract of human HeLa cells assessed as blockade of NFkappa p65 binding to biotinylated-consesus sequence by ELI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA helicase IV(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50177713(2-(5-oxo-5,11-dihydro-10-thia-dibenzo[a,d]cyclohep...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of ATPase activity of Helicase4 from Escherichia coli in presence of ATP (5x Km(ATP)) and dT25 (5x KDNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50535069(CHEMBL4448648)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged HIV1 integrase expressed in Escherichia coli BL21(DE3) cells assessed as reduction in LED...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50508835(CHEMBL4526711)
Affinity DataIC50:  3.55E+3nMAssay Description:Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Mus musculus)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505843(CHEMBL4449589 | US11174245, # I-235)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM241952(Fukugetin)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of trypsin (unknown origin) using Z-FR-MCA as substrate by spectrofluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Bangalore University

Curated by ChEMBL
LigandPNGBDBM50106333(CHEMBL3596289)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 143 total ) | Next | Last >>
Jump to: