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Found 19 with Last Name = 'furman' and Initial = 'pa'
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50480722(CHEMBL373691)
Affinity DataKi:  310nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50495953(CHEMBL3121385)
Affinity DataIC50:  5.31E+3nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNS5B(Hepatitis C virus)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50332459(((2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataIC50:  5.94E+3nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50495954(CHEMBL3121384)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50495956(CHEMBL223482 | PS-6130)
Affinity DataIC50:  5.67E+4nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333127((beta-D-2',3'-dideoxy-5'-F-cytidine-5'-triphosphat...)
Affinity DataIC50:  8.50E+4nMAssay Description:Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50495952(CHEMBL3121489)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50495957(CHEMBL3121492)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50495955(CHEMBL3121493)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase beta assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase II subunit RPB1(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333128(((2S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human RNA polymerase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase II subunit RPB1(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human RNA polymerase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333127((beta-D-2',3'-dideoxy-5'-F-cytidine-5'-triphosphat...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataIC50:  5.50E+5nMAssay Description:Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human DNA polymerase beta assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed