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Found 471 with Last Name = 'gadek' and Initial = 'tr'
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006294(6-Carboxymethyl-12-(3-guanidino-propyl)-5,8,11,14,...)
Affinity DataIC50:  0.5nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006294(6-Carboxymethyl-12-(3-guanidino-propyl)-5,8,11,14,...)
Affinity DataIC50:  0.5nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006340(11-Carboxymethyl-17-(3-guanidino-propyl)-4,10,13,1...)
Affinity DataIC50:  1nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50333919((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50368321(CHEMBL1790447)
Affinity DataIC50:  1.30nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006315(6-Carboxymethyl-12-(3-guanidino-propyl)-1,5,8,11,1...)
Affinity DataIC50:  1.40nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006315(6-Carboxymethyl-12-(3-guanidino-propyl)-1,5,8,11,1...)
Affinity DataIC50:  1.40nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006351(6-Carboxymethyl-12-(3-guanidino-propyl)-15-(4-hydr...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50368318(CHEMBL1790445)
Affinity DataIC50:  1.70nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50368320(CHEMBL1790443)
Affinity DataIC50:  1.80nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50368320(CHEMBL1790443)
Affinity DataIC50:  1.80nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101759((S)-2-(4-Chloro-benzenesulfonylamino)-3-({5-[2-(1,...)
Affinity DataIC50:  2nMAssay Description:Concentration required to reduce binding of human 293 cell attachment to immobilized vitronectin receptor(Vn/293) by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101766((S)-2-Ethenesulfonylamino-3-({5-[2-(1,4,5,6-tetrah...)
Affinity DataIC50:  2nMAssay Description:Concentration required to reduce binding of human 293 cell attachment to immobilized vitronectin receptor(Vn/293) by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101763((S)-2-(3-Chloro-propane-1-sulfonylamino)-3-({5-[2-...)
Affinity DataIC50:  2nMAssay Description:Concentration required to reduce binding of Kistrin to Vitronectin receptor (alpha V beta 3) by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101753((S)-2-(4-Isopropyl-benzenesulfonylamino)-3-({5-[2-...)
Affinity DataIC50:  2nMAssay Description:Concentration required to reduce binding of Kistrin to Vitronectin receptor (alpha V beta 3) by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101761((S)-3-({5-[2-(1,4,5,6-Tetrahydro-pyrimidin-2-ylcar...)
Affinity DataIC50:  2nMAssay Description:Concentration required to reduce binding of fibrinogen (Fg) to alpha IIb beta3 integrin by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101768((S)-3-({5-[2-(1,4,5,6-Tetrahydro-pyrimidin-2-ylcar...)
Affinity DataIC50:  2nMAssay Description:Concentration required to reduce binding of Kistrin to Vitronectin receptor (alpha V beta 3) by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101773((S)-2-(Naphthalene-1-sulfonylamino)-3-({5-[2-(1,4,...)
Affinity DataIC50:  2nMAssay Description:Concentration required to reduce binding of human 293 cell attachment to immobilized vitronectin receptor(Vn/293) by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101755((S)-2-(Adamantan-1-ylmethoxycarbonylamino)-3-{[5-(...)
Affinity DataIC50:  2nMAssay Description:Concentration required to reduce binding of Kistrin to Vitronectin receptor (alpha V beta 3) by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386338(CHEMBL2048036)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006314(6-Carboxymethyl-12-(3-guanidino-propyl)-15-isoprop...)
Affinity DataIC50:  2nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006300(6-Carboxymethyl-12-(3-guanidino-propyl)-15-(4-hydr...)
Affinity DataIC50:  2.10nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006287(6-Carboxymethyl-12-(3-guanidino-propyl)-15-methyl-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006349(CHEMBL64787 | [3-Carbamoyl-12-(3-guanidino-propyl)...)
Affinity DataIC50:  2.5nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006296(15-(4-Amino-butyl)-6-carboxymethyl-12-(3-guanidino...)
Affinity DataIC50:  2.60nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006297(15-Carbamoylmethyl-6-carboxymethyl-12-(3-guanidino...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006327(6-Carboxymethyl-12-(3-guanidino-propyl)-15-isoprop...)
Affinity DataIC50:  2.90nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386331(CHEMBL2048028)
Affinity DataIC50:  2.98nMAssay Description:Inhibition of human recombinant ICAM-1 adhesion into human Jurkat cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101769((S)-2-(4-tert-Butyl-benzenesulfonylamino)-3-({5-[2...)
Affinity DataIC50:  3nMAssay Description:Concentration required to reduce binding of human 293 cell attachment to immobilized vitronectin receptor(Vn/293) by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386328(CHEMBL2048025)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101779((S)-2-(Quinoline-8-sulfonylamino)-3-({5-[2-(1,4,5,...)
Affinity DataIC50:  3nMAssay Description:Concentration required to reduce binding of human 293 cell attachment to immobilized vitronectin receptor(Vn/293) by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006344(6-Carboxymethyl-12-(3-guanidino-propyl)-15-isobuty...)
Affinity DataIC50:  3nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101770((S)-2-(Biphenyl-4-sulfonylamino)-3-({5-[2-(1,4,5,6...)
Affinity DataIC50:  3nMAssay Description:Concentration required to reduce binding of fibrinogen (Fg) to alpha IIb beta3 integrin by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006283(6-Carboxymethyl-12-(3-guanidino-propyl)-15-(1H-imi...)
Affinity DataIC50:  3nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006270(6-Carboxymethyl-15-(2,2-dimethyl-propyl)-12-(3-gua...)
Affinity DataIC50:  3.60nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006346(6-Carboxymethyl-12-(3-guanidino-propyl)-15-isobuty...)
Affinity DataIC50:  3.90nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386325(CHEMBL2048402)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006303(6-Carboxymethyl-12-(3-guanidino-propyl)-5,8,11,14,...)
Affinity DataIC50:  4nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101764((S)-2-(Butane-1-sulfonylamino)-3-({5-[2-(1,4,5,6-t...)
Affinity DataIC50:  4nMAssay Description:Concentration required to reduce binding of fibrinogen (Fg) to alpha IIb beta3 integrin by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006345(6-Carboxymethyl-12-(3-guanidino-propyl)-15-hydroxy...)
Affinity DataIC50:  4nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006275(6-Carboxymethyl-12-(3-guanidino-propyl)-15-(1H-ind...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006298(6-Carboxymethyl-12-(3-guanidino-propyl)-15-(2-meth...)
Affinity DataIC50:  4nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101772((S)-2-Chloromethanesulfonylamino-3-({5-[2-(1,4,5,6...)
Affinity DataIC50:  4nMAssay Description:Concentration required to reduce binding of Kistrin to Vitronectin receptor (alpha V beta 3) by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50101771((S)-2-(Propane-1-sulfonylamino)-3-({5-[2-(1,4,5,6-...)
Affinity DataIC50:  4nMAssay Description:Concentration required to reduce binding of fibrinogen (Fg) to alpha IIb beta3 integrin by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006303(6-Carboxymethyl-12-(3-guanidino-propyl)-5,8,11,14,...)
Affinity DataIC50:  4nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006348(6-Carboxymethyl-12-(3-guanidino-propyl)-5,8,11,14,...)
Affinity DataIC50:  4.20nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006327(6-Carboxymethyl-12-(3-guanidino-propyl)-15-isoprop...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of Fibrinogen binding to Fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006323(CHEMBL302646 | [3-Carbamoyl-12-(3-guanidino-propyl...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006271(15-(2-Carboxy-ethyl)-6-carboxymethyl-12-(3-guanidi...)
Affinity DataIC50:  4.70nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50006302(6-Carboxymethyl-12-(3-guanidino-propyl)-15-methyl-...)
Affinity DataIC50:  4.70nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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