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Found 87 with Last Name = 'geng' and Initial = 'k'
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290261(CHEMBL4172925)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290292(CHEMBL4168049)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290519(CHEMBL4162295)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290472(CHEMBL4177038)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290293(CHEMBL4168701)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290291(CHEMBL4175908)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290386(CHEMBL4172048)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM634110(US20230357248, Example 1)
Affinity DataIC50:  1.70nMAssay Description:The specific assay process of BTK enzyme activity assay is as follows: Buffer: 20 mM 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (Hepes) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290258(CHEMBL4168868)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290258(CHEMBL4168868)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of recombinant ALK G1202R mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290258(CHEMBL4168868)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of recombinant ALK T1151M mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290260(CHEMBL4162252)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290258(CHEMBL4168868)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of recombinant ALK R1275Q mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50044303(CHEMBL3357439)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50044303(CHEMBL3357439)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290518(CHEMBL4170213)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50436850(CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290258(CHEMBL4168868)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of recombinant ALK L1196M mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50403641(CHEMBL4175858)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290294(CHEMBL4176561)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290386(CHEMBL4172048)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant ALK L1196M mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290258(CHEMBL4168868)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of recombinant ALK S1206Y mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50403604(CHEMBL4167999)
Affinity DataIC50:  6nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290291(CHEMBL4175908)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of recombinant ALK G1202R mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50403662(CHEMBL4159104)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM634115(US20230357248, Example 6)
Affinity DataIC50:  6.5nMAssay Description:The specific assay process of BTK enzyme activity assay is as follows: Buffer: 20 mM 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (Hepes) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM634112(US20230357248, Example 3)
Affinity DataIC50:  6.70nMAssay Description:The specific assay process of BTK enzyme activity assay is as follows: Buffer: 20 mM 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (Hepes) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50403656(CHEMBL4169444)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM634113(BDBM634121 | US20230357248, Example 4)
Affinity DataIC50:  7.30nMAssay Description:The specific assay process of BTK enzyme activity assay is as follows: Buffer: 20 mM 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (Hepes) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM643175(US20240002377, Compound 4)
Affinity DataIC50:  7.40nMAssay Description:1. The substrate was prepared in freshly prepared reaction buffer;2. The required cofactor was added to the above-mentioned substrate solution;3. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290386(CHEMBL4172048)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of recombinant ALK G1202R mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290264(CHEMBL4174031)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50403656(CHEMBL4169444)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM634117(US20230357248, Example 8)
Affinity DataIC50:  8.90nMAssay Description:The specific assay process of BTK enzyme activity assay is as follows: Buffer: 20 mM 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (Hepes) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM643176(US20240002377, Compound 5)
Affinity DataIC50:  8.90nMAssay Description:1. The substrate was prepared in freshly prepared reaction buffer;2. The required cofactor was added to the above-mentioned substrate solution;3. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50403604(CHEMBL4167999)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50403660(CHEMBL4159769)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM634114(US20230357248, Example 5)
Affinity DataIC50:  10.7nMAssay Description:The specific assay process of BTK enzyme activity assay is as follows: Buffer: 20 mM 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (Hepes) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290266(CHEMBL4170592)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290258(CHEMBL4168868)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant ALK L1152R mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM643173(US20240002377, Compound 2)
Affinity DataIC50:  11.7nMAssay Description:1. The substrate was prepared in freshly prepared reaction buffer;2. The required cofactor was added to the above-mentioned substrate solution;3. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to recombinant HSP90alpha (unknown origin) after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM634111(US20230357248, Example 2)
Affinity DataIC50:  12.5nMAssay Description:The specific assay process of BTK enzyme activity assay is as follows: Buffer: 20 mM 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (Hepes) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290472(CHEMBL4177038)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant ALK L1196M mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50005782(ATI-13387X | ONALESPIB)
Affinity DataIC50:  14nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to recombinant HSP90alpha (unknown origin) after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM634119(US20230357248, Example 10)
Affinity DataIC50:  14.9nMAssay Description:The specific assay process of BTK enzyme activity assay is as follows: Buffer: 20 mM 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (Hepes) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290292(CHEMBL4168049)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant ALK G1202R mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM634113(BDBM634121 | US20230357248, Example 4)
Affinity DataIC50:  15.1nMAssay Description:The specific assay process of BTK enzyme activity assay is as follows: Buffer: 20 mM 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (Hepes) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Medshine Discovery

US Patent
LigandPNGBDBM634118(US20230357248, Example 9)
Affinity DataIC50:  15.2nMAssay Description:The specific assay process of BTK enzyme activity assay is as follows: Buffer: 20 mM 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (Hepes) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50290472(CHEMBL4177038)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant ALK G1202R mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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