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Found 657 with Last Name = 'gharbaoui' and Initial = 't'
TargetProstacyclin receptor(RAT)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23954(5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydro...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23954(5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydro...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235370(CHEMBL3933704)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23515(CHEMBL573 | Niacin | Nicotinic Acid | [5, 6-3H]-ni...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetProstacyclin receptor(RAT)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235370(CHEMBL3933704)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(RAT)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50343442(CHEMBL1775179 | isopropyl 4-(1-(2-fluoro-4-(methyl...)
Affinity DataKi:  100nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  143nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235370(CHEMBL3933704)
Affinity DataKi:  210nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235380(CHEMBL3917503)
Affinity DataKi:  400nMAssay Description:Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[...)
Affinity DataKi:  505nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235370(CHEMBL3933704)
Affinity DataKi:  570nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  610nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  678nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235370(CHEMBL3933704)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235370(CHEMBL3933704)
Affinity DataKi:  1.85E+3nMAssay Description:Displacement of [3H]-PGD2 from recombinant human DP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of [3H]-PGD2 from recombinant human DP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23954(5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydro...)
Affinity DataKi:  3.70E+3nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  9.60E+3nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150119(CHEMBL3769414)
Affinity DataIC50:  0.0580nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataIC50:  1.90nMAssay Description:Induction of internalization of HA-tagged human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM289647(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against chymotrypsinogen; Range 1-10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23954(5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydro...)
Affinity DataIC50:  9nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235375(CHEMBL3975122)
Affinity DataIC50:  12nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235370(CHEMBL3933704)
Affinity DataIC50:  18nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235378(CHEMBL3981509)
Affinity DataIC50:  19nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235368(CHEMBL3893346)
Affinity DataIC50:  22nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235373(CHEMBL3928729)
Affinity DataIC50:  23nMAssay Description:Compound was tested for its inhibitory activity against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235376(CHEMBL3926078)
Affinity DataIC50:  23nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235367(CHEMBL3952237)
Affinity DataIC50:  25nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  26nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Affinity DataIC50:  27nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235389(CHEMBL3983767)
Affinity DataIC50:  30nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM289641(6-(4-Chloro-2-fluorobenzyl)-9-((tetrahydro-2H-pyra...)
Affinity DataIC50:  31nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataIC50:  38nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235374(CHEMBL3935924)
Affinity DataIC50:  39nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50059033((11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM289617(6-(4-Chlorobenzyl)-9-((tetrahydro-2H-pyran-4-yl)me...)
Affinity DataIC50:  41nMAssay Description:Inhibitory activity against chymotrypsinogen; Range 1-10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235379(CHEMBL3932106 | US10668033, Compound 55)
Affinity DataIC50:  43nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50059026(5'-Methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spi...)
Affinity DataIC50:  48nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM289669(6-(4-Chlorobenzyl)-9-(cyclopropanecarbonyl)-8,9,10...)
Affinity DataIC50:  53nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235384(CHEMBL3900038)
Affinity DataIC50:  54nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235372(CHEMBL3966307)
Affinity DataIC50:  54nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)
Affinity DataIC50:  59nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50237791(CHEMBL1628659 | SCH-51866)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory activity against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235383(ACT-293987 | NS-304 | Selexipag | Uptravi)
Affinity DataIC50:  62nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289613(6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropy...)
Affinity DataIC50:  69nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235371(CHEMBL3922000)
Affinity DataIC50:  93nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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