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Found 2136 with Last Name = 'gilbert' and Initial = 'am'
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Pfizer

LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataKi:  0.0269nMpH: 7.5Assay Description:Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Pfizer

LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataKi:  0.131nMpH: 7.5Assay Description:Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153628(4-[3-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-...)
Affinity DataKi:  0.140nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153629(4-[2-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138479((1R,3R,5S)-8-((S)-8-Methoxy-2,3-dihydro-benzo[1,4]...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153621((S)-1-[3-(3,4-Dichloro-phenyl)-8-aza-bicyclo[3.2.1...)
Affinity DataKi:  0.380nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153630(5-[2-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-...)
Affinity DataKi:  0.400nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153619(4-{2-[3-(3,4-Dichloro-phenyl)-8-aza-bicyclo[3.2.1]...)
Affinity DataKi:  0.5nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153627(8-[2-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-...)
Affinity DataKi:  0.5nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153625((S)-1-(1H-Indol-4-yloxy)-3-(3-naphthalen-2-yl-8-az...)
Affinity DataKi:  0.540nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Pfizer

LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataKi:  0.545nMpH: 7.5Assay Description:Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153632(1H-4-indolyl 3-[3-(1H-3-indolyl)-8-azabicyclo[3.2....)
Affinity DataKi:  0.650nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153633(4-{3-[3-(3,4-Dichloro-phenyl)-8-aza-bicyclo[3.2.1]...)
Affinity DataKi:  0.650nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Pfizer

LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataKi:  0.679nMpH: 7.5Assay Description:Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138478((1R,3R,5S)-8-((S)-8-Methoxy-2,3-dihydro-benzo[1,4]...)
Affinity DataKi:  0.810nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153626(1H-4-indolyl 2-[3-(1H-3-indolyl)-8-azabicyclo[3.2....)
Affinity DataKi:  1.20nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138483(8-((S)-8-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity of compound against serotonin transport by RB5-5-HT transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138480((1R,3R,5S)-8-((S)-8-Methoxy-2,3-dihydro-benzo[1,4]...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138474((1R,3R,5S)-3-Benzo[b]thiophen-3-yl-8-((S)-8-methox...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138485((1R,3R,5S)-8-((S)-8-Ethoxy-2,3-dihydro-benzo[1,4]d...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334105((4-methoxy-3-(phenylethynyl)phenyl)(4-(5-methylpyr...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138470((1R,3R,5S)-8-((S)-8-Ethoxy-2,3-dihydro-benzo[1,4]d...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153624(1-Methyl-4-[2-(3-naphthalen-2-yl-8-aza-bicyclo[3.2...)
Affinity DataKi:  4.40nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138471(3-(3,4-Dichloro-phenyl)-8-((S)-8-methoxy-2,3-dihyd...)
Affinity DataKi:  4.70nMAssay Description:Inhibitory activity of compound against serotonin transport by RB5-5-HT transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334106((3-((3-chlorophenyl)ethynyl)-4-methoxyphenyl)(4-(p...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153631(8-[2-(Indan-4-yloxy)-ethyl]-3-naphthalen-2-yl-8-az...)
Affinity DataKi:  5nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138473((1R,3R,5S)-8-((S)-8-Ethoxy-2,3-dihydro-benzo[1,4]d...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataKi:  6.31nMpH: 7.5Assay Description:Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138476(5-Fluoro-1-[8-((S)-8-methoxy-2,3-dihydro-benzo[1,4...)
Affinity DataKi:  8.5nMAssay Description:Inhibitory activity of compound against serotonin transport by RB5-5-HT transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138479((1R,3R,5S)-8-((S)-8-Methoxy-2,3-dihydro-benzo[1,4]...)
Affinity DataKi:  9.90nMAssay Description:Displacement of [3H]prazosin from alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153620(5-{2-[3-(1H-Indol-2-yl)-8-aza-bicyclo[3.2.1]oct-2-...)
Affinity DataKi:  11nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138485((1R,3R,5S)-8-((S)-8-Ethoxy-2,3-dihydro-benzo[1,4]d...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]prazosin from alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50153623(4-[2-(3-Benzo[b]thiophen-3-yl-8-aza-bicyclo[3.2.1]...)
Affinity DataKi:  15nMAssay Description:In vitro binding affinity for serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138472((1R,3R,5S)-3-Benzo[b]thiophen-3-yl-8-((S)-8-ethoxy...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334108((4-methoxy-3-(pyridin-2-ylethynyl)phenyl)(4-(5-met...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334107((4-methoxy-3-(phenylethynyl)phenyl)(4-(pyridin-2-y...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334109((4-methoxy-3-(pyridin-2-ylethynyl)phenyl)(4-(pyrid...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334110((4-methoxy-3-(thiazol-2-ylethynyl)phenyl)(4-(pyrid...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138475(8-((S)-8-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl...)
Affinity DataKi:  26nMAssay Description:Inhibitory activity of compound against serotonin transport by RB5-5-HT transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Pfizer

LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataKi:  27nMAssay Description:Inhibition of full length recombinant human GST-tagged cytoplasmic ITK expressed in baculovirus expression system by KT236 probe based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334111((4-methoxy-3-(phenylethynyl)phenyl)(4-(pyrazin-2-y...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334112((4-methoxy-3-(pyridin-2-ylethynyl)phenyl)(4-(pyrim...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Pfizer

LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataKi:  32.4nMpH: 7.5Assay Description:Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138477(8-[8-((S)-8-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2...)
Affinity DataKi:  33nMAssay Description:Inhibitory activity of compound against serotonin transport by RB5-5-HT transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138470((1R,3R,5S)-8-((S)-8-Ethoxy-2,3-dihydro-benzo[1,4]d...)
Affinity DataKi:  33nMAssay Description:Inhibitory activity of compound against serotonin transport by HC5-5-HT transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334113((4-methoxy-3-((6-methylpyridin-2-yl)ethynyl)phenyl...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138484((1R,3R,5S)-8-((S)-8-Methoxy-2,3-dihydro-benzo[1,4]...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138478((1R,3R,5S)-8-((S)-8-Methoxy-2,3-dihydro-benzo[1,4]...)
Affinity DataKi:  42nMAssay Description:Inhibitory activity of compound against serotonin transport by RB5-5-HT transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138481((1R,3R,5S)-8-((S)-8-Methoxy-2,3-dihydro-benzo[1,4]...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50138477(8-[8-((S)-8-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]prazosin from alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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