Found 192 with Last Name = 'giorgis' and Initial = 'm' 
Affinity DataKi: 9.60E+3nMAssay Description:Inhibition of caspase 1 (unknown origin) using N-acetyl-Tyr-Val-Ala-Asp-para-nitroanilide substrate assessed as rate of para-nitroanilide release by ...More data for this Ligand-Target Pair
Affinity DataKi: 1.06E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using N-acetyl-Tyr-Val-Ala-Asp-para-nitroanilide substrate assessed as rate of para-nitroanilide release by ...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 0.820nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
Ligand Info
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 1nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human N-terminal GST-fusion tagged DHODH expressed in Escherichia coli BL21 (DE3) using dihydroorotate as substrate at 50 u...More data for this Ligand-Target Pair
3D Structure (crystal)TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 1.20nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli BL21(DE3) assessed as inhibition of DC...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 1.35nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 1.48nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
Ligand Info
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli BL21(DE3) assessed as inhibition of DC...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 1.80nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human N-terminal GST-fusion tagged DHODH expressed in Escherichia coli BL21 (DE3) using dihydroorotate as substrate at 50 u...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human N-terminal truncated GST-tagged DHFR (31 to 395 residues) expressed in Escherichia coli BL21(DE3) pyrD using DHO as s...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 2.03nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 2.30nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 2.5nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
Ligand Info
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 2.75nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 2.78nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 3.29nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
Ligand Info
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 3.40nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 4.09nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 4.30nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli BL21(DE3) assessed as inhibition of DC...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 4.30nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 5.80nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 6nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 6.23nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 6.34nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human N-terminal GST-fusion tagged DHODH (31 to 395 residues) expressed in Escherichia coli BL21-GOLD (DE3) using dihydroorotate as sub...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 7.20nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 13nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human N-terminal truncated GST-tagged DHFR (31 to 395 residues) expressed in Escherichia coli BL21(DE3) pyrD using DHO as s...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 17.7nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 18nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Drug Discovery and Clinic
US Patent
Drug Discovery and Clinic
US Patent
Affinity DataIC50: 18nMAssay Description:Inhibition of human N-terminal GST-fusion tagged DHODH (31 to 395 residues) expressed in Escherichia coli BL21-GOLD (DE3) using dihydroorotate as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human N-terminal truncated GST-tagged DHFR (31 to 395 residues) expressed in Escherichia coli BL21(DE3) pyrD using DHO as s...More data for this Ligand-Target Pair
