TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre
Curated by ChEMBL
Experimental Drug Development Centre
Curated by ChEMBL
Affinity DataKi: 440nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre
Curated by ChEMBL
Experimental Drug Development Centre
Curated by ChEMBL
Affinity DataKi: 3.06E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre
Curated by ChEMBL
Experimental Drug Development Centre
Curated by ChEMBL
Affinity DataKi: 3.90E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Affinity DataIC50: <0.170nMAssay Description:Inhibition of HDAC6 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.790nMAssay Description:Inhibition of HDAC6 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of HDAC3 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HDAC3 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of HDAC10 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of HDAC3 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of HDAC1 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of HDAC6 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Inhibition of HDAC10 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of HDAC1 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of HDAC1 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of HDAC10 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)
Curated by ChEMBL
Agency For Science, Technology And Research (A*Star)
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 3a (isolate NZL1) (HCV))
Biota Scientific Management
US Patent
Biota Scientific Management
US Patent
Affinity DataIC50: 10nMAssay Description:HCV polymerase inhibition assay: HCV polymerase reactions were carried out using a modified mothod of Howe et al., Antimicrobial Agents and Chemothe...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)
Curated by ChEMBL
Agency For Science, Technology And Research (A*Star)
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre
Curated by ChEMBL
Experimental Drug Development Centre
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 30 mins followed by substrate addition and measured after 30 mi...More data for this Ligand-Target Pair