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Found 622 with Last Name = 'giri' and Initial = 's'
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502427(CHEMBL4542517)
Affinity DataKi:  440nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502433(CHEMBL4575866)
Affinity DataKi:  3.06E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502434(CHEMBL4551647)
Affinity DataKi:  3.90E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone deacetylase 6(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50526157(CHEMBL4550526)
Affinity DataIC50: <0.170nMAssay Description:Inhibition of HDAC6 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50526161(CHEMBL4464421)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of HDAC6 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

LigandPNGBDBM26034(4-({2-[(4-bromophenyl)amino]-1-methyl-1H-1,3-benzo...)
Affinity DataIC50:  1nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  1nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

LigandPNGBDBM26023(4-({2-[(4-bromophenyl)(methyl)amino]-1H-1,3-benzod...)
Affinity DataIC50:  1nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50526161(CHEMBL4464421)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of HDAC3 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50526157(CHEMBL4550526)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of HDAC3 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

LigandPNGBDBM26023(4-({2-[(4-bromophenyl)(methyl)amino]-1H-1,3-benzod...)
Affinity DataIC50:  2nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547958(CHEMBL4789918)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50526161(CHEMBL4464421)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of HDAC10 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50526156(CHEMBL1630208 | WR301861)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of HDAC3 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50526161(CHEMBL4464421)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of HDAC1 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547947(CHEMBL4760206)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547949(CHEMBL4743091)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50526156(CHEMBL1630208 | WR301861)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of HDAC6 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547959(CHEMBL4750630)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547962(CHEMBL4784665)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547955(CHEMBL4796558)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50526156(CHEMBL1630208 | WR301861)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of HDAC10 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50526156(CHEMBL1630208 | WR301861)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of HDAC1 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

LigandPNGBDBM26037(4-({2-[(4-bromophenyl)amino]-1-methyl-1H-1,3-benzo...)
Affinity DataIC50:  4nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

LigandPNGBDBM26022(4-({2-[(3-bromophenyl)(methyl)amino]-1H-1,3-benzod...)
Affinity DataIC50:  4nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

LigandPNGBDBM26028(4-({2-[(3-tert-butylphenyl)(methyl)amino]-1H-1,3-b...)
Affinity DataIC50:  4nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50526157(CHEMBL4550526)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of HDAC1 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547954(CHEMBL4763990)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547953(CHEMBL4790506)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50526157(CHEMBL4550526)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of HDAC10 (unknown origin) using (FAM)-labeled acetylated peptide as substrate measured after 17 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

LigandPNGBDBM26025(N-methyl-4-[(2-{methyl[3-(trifluoromethyl)phenyl]a...)
Affinity DataIC50:  6nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547961(CHEMBL4777409)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

LigandPNGBDBM26038(4-({2-[(4-bromophenyl)amino]-1-methyl-1H-1,3-benzo...)
Affinity DataIC50:  7nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

LigandPNGBDBM26017(4-({2-[(3-tert-butylphenyl)amino]-1H-1,3-benzodiaz...)
Affinity DataIC50:  8nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547946(CHEMBL4757687)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

LigandPNGBDBM26025(N-methyl-4-[(2-{methyl[3-(trifluoromethyl)phenyl]a...)
Affinity DataIC50:  8nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM375523(4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...)
Affinity DataIC50:  9nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547963(CHEMBL4757349)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

LigandPNGBDBM26029(4-({2-[(4-tert-butylphenyl)(methyl)amino]-1H-1,3-b...)
Affinity DataIC50:  9nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

LigandPNGBDBM26026(N-methyl-4-[(2-{methyl[4-(trifluoromethyl)phenyl]a...)
Affinity DataIC50:  9nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

LigandPNGBDBM26021(4-({2-[(2-bromophenyl)(methyl)amino]-1H-1,3-benzod...)
Affinity DataIC50:  10nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 3a (isolate NZL1) (HCV))
Biota Scientific Management

US Patent
LigandPNGBDBM103282(US8546389, 4)
Affinity DataIC50:  10nMAssay Description:HCV polymerase inhibition assay: HCV polymerase reactions were carried out using a modified mothod of Howe et al., Antimicrobial Agents and Chemothe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547948(CHEMBL4742305)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

LigandPNGBDBM26032(N-methyl-4-[(2-{methyl[3-(pyridin-4-yl)phenyl]amin...)
Affinity DataIC50:  10nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

LigandPNGBDBM26037(4-({2-[(4-bromophenyl)amino]-1-methyl-1H-1,3-benzo...)
Affinity DataIC50:  11nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  11nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM375523(4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...)
Affinity DataIC50:  11nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547950(CHEMBL4748475)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

LigandPNGBDBM26016(N-methyl-4-[(2-{[4-(trifluoromethyl)phenyl]amino}-...)
Affinity DataIC50:  11nMAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502427(CHEMBL4542517)
Affinity DataIC50:  12nMAssay Description:Inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 30 mins followed by substrate addition and measured after 30 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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