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Found 157 with Last Name = 'goljer' and Initial = 'i'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259277((R,S/S,R)-syn-1-((4-methoxyphenyl)(methyl)amino)-3...)
Affinity DataIC50:  3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataIC50:  3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50124566((R)-2-((R)-(2-ethoxyphenoxy)(phenyl)methyl)morphol...)
Affinity DataIC50:  3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50366567(ATOMOXETINE)
Affinity DataIC50:  3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataIC50:  4nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...)
Affinity DataIC50:  9nMAssay Description:Binding affinity to human recombinant LXRbeta ligand binding domainMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataIC50:  10nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259340((1S,2R)-1-(3-fluorophenyl)-1-(methyl(phenyl)amino)...)
Affinity DataIC50:  12nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]T0901317 from human LXRalpha ligand binding domainMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259276((R,S/S,R)-syn-1-((3-methoxyphenyl)(methyl)amino)-3...)
Affinity DataIC50:  17nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316094(3-Ethyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(tr...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]T0901317 from human LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259273((R,S/S,R)-syn-1-((3-chlorophenyl)(methyl)amino)-3-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265547(CHEMBL455476 | N-{1-[1-(3,3-Dimethylbutanoyl)-L-pr...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265554((2S)-N-(tert-Butyl)-2-{[4-({[5-(phenylsulfonyl)-2-...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265555((2S)-N-Phenyl-2-{[4-({[5-(phenylsulfonyl)-2-(trifl...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)
Affinity DataIC50:  22nMAssay Description:Inhibition of [3H]WIN-35428 binding to human recombinant DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259274((R,S/S,R)-syn-1-((4-chlorophenyl)(methyl)amino)-3-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259274((R,S/S,R)-syn-1-((4-chlorophenyl)(methyl)amino)-3-...)
Affinity DataIC50:  23nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259230((R,S/S,R)-syn-1-(methyl(p-tolyl)amino)-3-(methylam...)
Affinity DataIC50:  29nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265580((2S)-N,N-Dimethyl-2-{[4-({[5-(phenylsulfonyl)-2-(t...)
Affinity DataIC50:  30nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265499(CHEMBL495534 | N-[1-(1H-Imidazol-1-ylacetyl)piperi...)
Affinity DataIC50:  30nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265553((2S)-N-Ethyl-2-{[4-({[5-(phenylsulfonyl)-2-(triflu...)
Affinity DataIC50:  30nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259227((R,S/S,R)-syn-1-(methyl(phenyl)amino)-3-(methylami...)
Affinity DataIC50:  30nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265583(CHEMBL451431 | N-{1-[1-(3,3-Dimethylbutyl)-L-proly...)
Affinity DataIC50:  30nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259229((R,S/S,R)-syn-1-(methyl(m-tolyl)amino)-3-(methylam...)
Affinity DataIC50:  32nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259231((R,S/S,R)-syn-1-((4-fluorophenyl)(methyl)amino)-3-...)
Affinity DataIC50:  33nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316092(5-Chloro-3-methyl-2-[3'-(methylsulfonyl)biphenyl-4...)
Affinity DataIC50:  34nMAssay Description:Displacement of [3H]T0901317 from human LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259343((R,S/S,R)-syn-1-(4-methoxyphenyl)-1-(methyl(phenyl...)
Affinity DataIC50:  34nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265545(CHEMBL500903 | N-[1-(1-Isobutyryl-L-prolyl)piperid...)
Affinity DataIC50:  40nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265584(CHEMBL503281 | N-{1-[1-(Cyclohexylmethyl)-L-prolyl...)
Affinity DataIC50:  40nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265581(CHEMBL505036 | N-{1-[1-(Morpholin-4-ylcarbonyl)-L-...)
Affinity DataIC50:  40nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265546(CHEMBL447079 | N-{1-[1-(2,2-Dimethylpropanoyl)-L-p...)
Affinity DataIC50:  40nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259273((R,S/S,R)-syn-1-((3-chlorophenyl)(methyl)amino)-3-...)
Affinity DataIC50:  41nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50366567(ATOMOXETINE)
Affinity DataIC50:  48nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265549(CHEMBL507695 | N-{1-[1-(Cyclohexylcarbonyl)-L-prol...)
Affinity DataIC50:  50nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316097(3-Methyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(t...)
Affinity DataIC50:  53nMAssay Description:Displacement of [3H]T0901317 from human LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259343((R,S/S,R)-syn-1-(4-methoxyphenyl)-1-(methyl(phenyl...)
Affinity DataIC50:  55nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265500((S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluo...)
Affinity DataIC50:  60nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305494(4-(3-(3-chloro-5-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50:  61nMAssay Description:Displacement of [3H]T0901317 from human LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259229((R,S/S,R)-syn-1-(methyl(m-tolyl)amino)-3-(methylam...)
Affinity DataIC50:  61nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259231((R,S/S,R)-syn-1-((4-fluorophenyl)(methyl)amino)-3-...)
Affinity DataIC50:  62nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259344((R,S/S,R)-syn-3-amino-1-(methyl(phenyl)amino)-1-ph...)
Affinity DataIC50:  68nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265552(CHEMBL454478 | N-[1-(1-Isonicotinoyl-L-prolyl)pipe...)
Affinity DataIC50:  70nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265550(CHEMBL510748 | N-[1-(1-Benzoyl-L-prolyl)piperidin-...)
Affinity DataIC50:  70nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259341((R,S/S,R)-syn-1-(3-chlorophenyl)-1-(methyl(phenyl)...)
Affinity DataIC50:  73nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259230((R,S/S,R)-syn-1-(methyl(p-tolyl)amino)-3-(methylam...)
Affinity DataIC50:  73nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259227((R,S/S,R)-syn-1-(methyl(phenyl)amino)-3-(methylami...)
Affinity DataIC50:  76nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316096(CHEMBL1090916 | N-Methyl-4'-[3-methyl-5-(trifluoro...)
Affinity DataIC50:  81nMAssay Description:Displacement of [3H]T0901317 from human LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted frizzled-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265505(CHEMBL525899 | N-[1-(5-oxo-L-Prolyl)piperidin-4-yl...)
Affinity DataIC50:  90nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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