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Found 14 with Last Name = 'goodlett' and Initial = 'dr'
TargetCytochrome P450 2B6(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataKi:  4.60E+3nMAssay Description:Competitive reversible inhibition of CYP2B6 in human liver microsomes incubated for 3 mins prior to NADPH addition measured after 10 mins by Dixon pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataKi:  2.50E+4nMAssay Description:Competitive inhibition of recombinant CYP3A4 (unknown origin) incubated for 3 mins prior to NADPH addition measured after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Pacific University Oregon

Curated by ChEMBL
LigandPNGBDBM50088436(BS-749 | CHEBI:76987 | Metacetamol)
Affinity DataKi:  9.50E+6nMAssay Description:Inhibition of human CYP2E1 assessed as chlorzoxazone 6-hydroxylase activity by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes incubated for 3 mins prior to NADPH addition measured after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataIC50:  1.21E+4nMAssay Description:Inhibition of recombinant CYP2B6 (unknown origin) incubated for 3 mins prior to NADPH addition measured after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) incubated for 3 mins prior to NADPH addition measured after 3 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes incubated for 3 mins prior to NADPH addition measured after 3 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088446(CHEBI:207229 | CHEMBL25164)
Affinity DataIC50: >1.25E+5nMAssay Description:Inhibition of CYP2B6 in human liver microsomes incubated for 3 mins prior to NADPH addition measured after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088446(CHEBI:207229 | CHEMBL25164)
Affinity DataIC50: >1.25E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes incubated for 3 mins prior to NADPH addition measured after 3 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088446(CHEBI:207229 | CHEMBL25164)
Affinity DataIC50: >1.25E+5nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) incubated for 3 mins prior to NADPH addition measured after 3 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088446(CHEBI:207229 | CHEMBL25164)
Affinity DataIC50: >1.25E+5nMAssay Description:Inhibition of recombinant CYP2B6 (unknown origin) incubated for 3 mins prior to NADPH addition measured after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataEC50:  3.00E+4nMAssay Description:Activation of human PXR expressed in human LS174T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataEC50:  600nMAssay Description:Induction of CYP2B6 in human hepatocytes after 72 hrs relative to vehicle-treated controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataEC50:  5.90E+3nMAssay Description:Induction of CYP3A4 in human hepatocytes after 72 hrs relative to vehicle-treated controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed