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Found 91 with Last Name = 'gourvest' and Initial = 'jf'
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50005878(4-Chloromethylsulfanyl-10,13-dimethyl-1,6,7,8,10,1...)
Affinity DataKi:  27nMAssay Description:Inhibition constant for human placental cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)
Affinity DataKi:  27nMAssay Description:Inhibition constant for human placental cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50005876(4-Chloromethylsulfanyl-10,13-dimethyl-1,6,7,8,9,10...)
Affinity DataKi:  30nMAssay Description:Inhibition constant for human placental cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50005874(4-Fluoromethylsulfanyl-10,13-dimethyl-1,6,7,8,9,10...)
Affinity DataKi:  30nMAssay Description:Inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50005875(4-Mercapto-10,13-dimethyl-1,6,7,8,10,12,13,14,15,1...)
Affinity DataKi:  72nMAssay Description:Inhibition constant for human placental cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50406730(CHEMBL2113619)
Affinity DataKi:  169nMAssay Description:Inhibition constant for human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM50366682(CHEMBL1627395)
Affinity DataIC50:  2.10nMAssay Description:Compound was tested for the inhibition of type 2 5-alpha-reductase of human prostatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM50101143(4'-[(Diisopropylcarbamoyl)-methoxy]-5'-fluoro-3'-n...)
Affinity DataIC50:  9.80nMAssay Description:Compound was tested for the inhibition of type 2 5-alpha-reductase of human prostatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10045((2R,15S)-15-methyl-2-[2-(methylsulfanyl)ethyl]tetr...)
Affinity DataIC50:  12nMpH: 7.2 T: 2°CAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085011(2-Benzyloxycarbonylamino-3-(2-{(S)-4-[3-(4,5-dihyd...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Kistrin binding to integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10046((2S,15S)-15-methyl-2-[2-(methylsulfanyl)ethyl]tetr...)
Affinity DataIC50:  22nMpH: 7.2 T: 2°CAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085018(3-(2-{(S)-4-[3-(1H-Benzoimidazol-2-ylamino)-propyl...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Kistrin binding to integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM50101145((4aR,6aS,7S,11aR)-4a,6a-Dimethyl-2-oxo-hexadecahyd...)
Affinity DataIC50:  41nMAssay Description:Compound was tested for the inhibition of type 2 5-alpha-reductase of human prostatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10044((2S,15S)-15-methyl-2-[(methylsulfanyl)methyl]tetra...)
Affinity DataIC50:  42nMpH: 7.2 T: 2°CAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10064((2R,15S)-2-[2-(ethenylsulfanyl)ethyl]-15-methyltet...)
Affinity DataIC50:  50nMAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10069((2R,15S)-2-{2-[(fluoromethyl)sulfanyl]ethyl}-15-me...)
Affinity DataIC50:  50nMAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM50101155(4'-[(Diisopropylcarbamoyl)-methoxy]-3',5'-diisopro...)
Affinity DataIC50:  71nMAssay Description:Compound was tested for the inhibition of Steroid 5-alpha-reductase type 2 of human prostatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085015(2-Benzyloxycarbonylamino-3-{2-[(S)-4-(3-guanidino-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Kistrin binding to integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM50101154(5'-Fluoro-3'-nitro-4'-[(trityl-carbamoyl)-methoxy]...)
Affinity DataIC50:  92nMAssay Description:Compound was tested for the inhibition of type 2 5-alpha-reductase of human prostatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085019(2-(3-Benzyl-ureido)-3-{2-[(S)-4-(3-guanidino-propy...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Kistrin binding to integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085006(2-Benzyloxycarbonylamino-3-{2-[(S)-4-(4-guanidino-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Kistrin binding to integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085010(3-{2-[(S)-4-(3-Guanidino-propyl)-2,5-dioxo-imidazo...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Kistrin binding to integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085010(3-{2-[(S)-4-(3-Guanidino-propyl)-2,5-dioxo-imidazo...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Kistrin binding to integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10063((2R,15S)-15-methyl-2-[2-(prop-2-en-1-ylsulfanyl)et...)
Affinity DataIC50:  270nMAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10068((2R,15S)-2-[2-(ethynylsulfanyl)ethyl]-15-methyltet...)
Affinity DataIC50:  330nMAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50005873(4-Hydroxy-10,13-dimethyl-1,6,7,8,10,12,13,14,15,16...)
Affinity DataIC50:  350nMAssay Description:Inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085008(3-{2-[(S)-4-(3-Guanidino-propyl)-2,5-dioxo-imidazo...)
Affinity DataIC50:  350nMAssay Description:Inhibition of Kistrin binding to integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085012(2-(Butane-1-sulfonylamino)-3-{2-[(S)-4-(3-guanidin...)
Affinity DataIC50:  350nMAssay Description:Inhibition of Kistrin binding to integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM50101153(4'-[(Diisopropylcarbamoyl)-methoxy]-3'-ethyl-biphe...)
Affinity DataIC50:  350nMAssay Description:Compound was tested for the inhibition of type 2 5-alpha-reductase of human prostatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)
Affinity DataIC50:  370nMAssay Description:Inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10054((2R,15S)-15-methyl-2-[2-(phenylsulfanyl)ethyl]tetr...)
Affinity DataIC50:  400nMpH: 7.2 T: 2°CAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085008(3-{2-[(S)-4-(3-Guanidino-propyl)-2,5-dioxo-imidazo...)
Affinity DataIC50:  550nMAssay Description:Inhibition of fibrinogen binding to integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10062((2R,15S)-15-methyl-2-(2-{[(methylsulfanyl)methyl]s...)
Affinity DataIC50:  570nMAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM50101146(4'-[(Diisopropylcarbamoyl)-methoxy]-2-trifluoromet...)
Affinity DataIC50:  570nMAssay Description:Compound was tested for the inhibition of Steroid 5-alpha-reductase type 2 of human prostatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085019(2-(3-Benzyl-ureido)-3-{2-[(S)-4-(3-guanidino-propy...)
Affinity DataIC50:  570nMAssay Description:Inhibition of Kistrin binding to integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085007(2-Benzyloxycarbonylamino-3-(2-{(S)-4-[N'-(4,5-dihy...)
Affinity DataIC50:  580nMAssay Description:Inhibition of Kistrin binding to integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085012(2-(Butane-1-sulfonylamino)-3-{2-[(S)-4-(3-guanidin...)
Affinity DataIC50:  760nMAssay Description:Inhibition of Kistrin binding to integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50005874(4-Fluoromethylsulfanyl-10,13-dimethyl-1,6,7,8,9,10...)
Affinity DataIC50:  800nMAssay Description:Inhibition of Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM50101149(4'-[(Diisopropylcarbamoyl)-methoxy]-biphenyl-4-car...)
Affinity DataIC50:  830nMAssay Description:Compound was tested for the inhibition of Steroid 5-alpha-reductase type 2 of human prostatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50085006(2-Benzyloxycarbonylamino-3-{2-[(S)-4-(4-guanidino-...)
Affinity DataIC50:  850nMAssay Description:Inhibition of fibrinogen binding to integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50005878(4-Chloromethylsulfanyl-10,13-dimethyl-1,6,7,8,10,1...)
Affinity DataIC50:  860nMAssay Description:Inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM50101156(2-Chloro-4'-[(diisopropylcarbamoyl)-methoxy]-biphe...)
Affinity DataIC50:  870nMAssay Description:Compound was tested for the inhibition of Steroid 5-alpha-reductase type 2 of human prostatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10047((2R,15S)-2-[2-(ethylsulfanyl)ethyl]-15-methyltetra...)
Affinity DataIC50:  870nMpH: 7.2 T: 2°CAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50005876(4-Chloromethylsulfanyl-10,13-dimethyl-1,6,7,8,9,10...)
Affinity DataIC50:  940nMAssay Description:Inhibition constant for human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10072((2R,15S)-2-[2,2-bis(ethylsulfanyl)ethyl]-15-methyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10071((2R,15S)-2-[2,2-bis(methylsulfanyl)ethyl]-15-methy...)
Affinity DataIC50: >1.00E+3nMAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10057((2R,15S)-2-{2-[(2-chloroethyl)sulfanyl]ethyl}-15-m...)
Affinity DataIC50: >1.00E+3nMpH: 7.2 T: 2°CAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10066((2R,15S)-15-methyl-2-[2-(phenyldisulfanyl)ethyl]te...)
Affinity DataIC50: >1.00E+3nMAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10065((2R,15S)-15-methyl-2-[2-(methyldisulfanyl)ethyl]te...)
Affinity DataIC50: >1.00E+3nMAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10061((2R,15S)-15-methyl-2-[2-(prop-2-yn-1-ylsulfanyl)et...)
Affinity DataIC50:  1.00E+3nMAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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