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Found 1537 with Last Name = 'graf' and Initial = 'r'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302220(7-((1-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308167((3R)-N,N-Dimethyl-1-[3-(1-naphthylsulfonyl)-1H-ind...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  2nMAssay Description:Agonist activity at 5-HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  2nMAssay Description:Agonist activity at 5-HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302218(7-(1-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-y...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308181((3S)-1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]pyr...)
Affinity DataKi:  3.06nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308183(1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]azetidin...)
Affinity DataKi:  3.55nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308177(1-{3-[(4-Methyl-1-naphthyl)sulfonyl]-1H-indazol-5-...)
Affinity DataKi:  3.62nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308175(1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]piperidi...)
Affinity DataKi:  4.27nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308182((3R)-1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]pyr...)
Affinity DataKi:  4.46nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308178(1-{3-[(5-Chloro-1-naphthyl)sulfonyl]-1H-indazol-5-...)
Affinity DataKi:  4.52nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302212((3S)-3-((3-( 6-fluoro-2,3,4,9-tetrahydro-1H-carbaz...)
Affinity DataKi:  6nMAssay Description:Agonist activity at 5-HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataKi:  6.20nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302224(7-((1R,4R)-5-((6-fluoro-2,3,4,9-tetrahydro-1H-carb...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308179(1-(3-(3-chlorophenylsulfonyl)-1H-indazol-5-yl)pipe...)
Affinity DataKi:  8.04nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302221(7-((1-(2-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378462(CHEMBL1237149)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308180(1-{3-[(4-Isopropylphenyl)sulfonyl]-1H-indazol-5-yl...)
Affinity DataKi:  13.1nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308170((3R)-1-[1-(1-Methylethyl)-3-(naphthalen-1-ylsulfon...)
Affinity DataKi:  13.7nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302224(7-((1R,4R)-5-((6-fluoro-2,3,4,9-tetrahydro-1H-carb...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302223(4-(4-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-y...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302212((3S)-3-((3-( 6-fluoro-2,3,4,9-tetrahydro-1H-carbaz...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302212((3S)-3-((3-( 6-fluoro-2,3,4,9-tetrahydro-1H-carbaz...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308176(1-[3-(2-Naphthylsulfonyl)-1H-indazol-5-yl]piperidi...)
Affinity DataKi:  18.2nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302214((3S)-3-((2-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazo...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308181((3S)-1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]pyr...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308169((3R)-1-[1-Methyl-3-(naphthalen-1-ylsulfonyl)-1H-in...)
Affinity DataKi:  21.1nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302214((3S)-3-((2-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazo...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302214((3S)-3-((2-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazo...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302214((3S)-3-((2-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazo...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308168((3S)-N,N-Dimethyl-1-[3-(1-naphthylsulfonyl)-1H-ind...)
Affinity DataKi:  24.4nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302210((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302220(7-((1-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302217(7-(4-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-y...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302217(7-(4-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-y...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302211((3S)-3-((2-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazo...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308171((3R)-1-[1-(2-Methylpropyl)-3-(naphthalen-1-ylsulfo...)
Affinity DataKi:  36.9nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302222(7-((4-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataKi:  44nMAssay Description:Inhibition of hexa-His-tagged JNK1 expressed in baculoviral system using GST-tagged c-Jun as substrate preincubated for 15 mins prior ATP addition me...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308173((3R)-1-[2-(1-Methylethyl)-3-(naphthalen-1-ylsulfon...)
Affinity DataKi:  48.7nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302212((3S)-3-((3-( 6-fluoro-2,3,4,9-tetrahydro-1H-carbaz...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302216(7-(4-(3-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-2...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302212((3S)-3-((3-( 6-fluoro-2,3,4,9-tetrahydro-1H-carbaz...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308172((3R)-1-[2-Methyl-3-(naphthalen-1-ylsulfonyl)-2H-in...)
Affinity DataKi:  54.3nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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