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Found 277 with Last Name = 'grenier' and Initial = 'l'
TargetCathepsin B(Homo sapiens (Human))
Proscript

Curated by ChEMBL
LigandPNGBDBM50069984((R)-1-((S)-2-((S)-2-(benzyloxycarbonyl)-4-methylpe...)
Affinity DataKi:  6.10nMAssay Description:Inhibitory activity against Cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Homo sapiens (Human))
Proscript

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataKi:  320nMAssay Description:Inhibitory activity against human ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Proscript

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataKi:  630nMAssay Description:Inhibitory activity against human cathepsin GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Proscript

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Proscript

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 2(Bos taurus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50228710(CHEMBL3349899)
Affinity DataIC50:  0.0430nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on bovine adrenal zona glomerulosa cell membranes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Mus musculus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50228710(CHEMBL3349899)
Affinity DataIC50:  0.130nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on mouse fibroblasts (NIH 3T3) cells (Atrionatriu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Mus musculus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013340(CHEMBL3349626)
Affinity DataIC50:  0.210nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites onmouse fibroblasts (NIH 3T3) cells (Atrionatriur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Mus musculus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013343(CHEMBL3349621 | deamino [Mpr105,Cys121] r-ANF (99-...)
Affinity DataIC50:  0.220nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites onmouse fibroblasts (NIH 3T3) cells (Atrionatriur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Mus musculus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013338(CHEMBL413659 | r-ANF (103-126)(Atrial Natriuretic ...)
Affinity DataIC50:  0.350nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites onmouse fibroblasts (NIH 3T3) cells (Atrionatriur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Mus musculus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013341(CHEMBL3349629)
Affinity DataIC50:  0.350nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites onmouse fibroblasts (NIH 3T3) cells (Atrionatriur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Mus musculus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013342(CHEMBL3349625)
Affinity DataIC50:  0.400nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites onmouse fibroblasts (NIH 3T3) cells (Atrionatriur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Mus musculus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50228711(CHEMBL3349900)
Affinity DataIC50:  0.5nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on mouse fibroblasts (NIH 3T3) cells (Atrionatriu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Mus musculus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013344(CHEMBL3349628)
Affinity DataIC50:  0.560nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites onmouse fibroblasts (NIH 3T3) cells (Atrionatriur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Mus musculus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50228712(CHEMBL3350078)
Affinity DataIC50:  0.630nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on mouse fibroblasts (NIH 3T3) cells (Atrionatriu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033458((S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-(2-Benzyl-3-phen...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Mus musculus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013339(CHEMBL3349627)
Affinity DataIC50:  0.780nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites onmouse fibroblasts (NIH 3T3) cells (Atrionatriur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 2(Bos taurus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013343(CHEMBL3349621 | deamino [Mpr105,Cys121] r-ANF (99-...)
Affinity DataIC50:  1nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on bovine adrenal zona glomerulosa cell membranes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033457(1-[(S)-((S)-1-Carboxy-3-methyl-butylcarbamoyl)-((S...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Mus musculus (Mouse))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192880(CHEMBL3984425 | US10329299, Compound 21 | US106752...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW264.7 cells assessed as reduction in AKT phosphorylation at S473 incubated for 30 mins followed by...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 2(Bos taurus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013338(CHEMBL413659 | r-ANF (103-126)(Atrial Natriuretic ...)
Affinity DataIC50:  1.40nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on bovine adrenal zona glomerulosa cell membranes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 2(Bos taurus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50228711(CHEMBL3349900)
Affinity DataIC50:  3.60nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on bovine adrenal zona glomerulosa cell membranes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033463((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-3,3-dimethyl-2-...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033465((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-3-methyl-2-[(S)...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 2(Bos taurus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013344(CHEMBL3349628)
Affinity DataIC50:  6.20nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on bovine adrenal zona glomerulosa cell membranes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033453(1-((S)-((S)-1-Carboxy-3-methyl-butylcarbamoyl)-{(S...)
Affinity DataIC50:  6.40nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033470((S)-2-{(S)-3-Carboxy-2-[(S)-2-((S)-3-methyl-2-{(S)...)
Affinity DataIC50:  7.5nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 2(Bos taurus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013340(CHEMBL3349626)
Affinity DataIC50:  7.80nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on bovine adrenal zona glomerulosa cell membranes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 2(Bos taurus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013341(CHEMBL3349629)
Affinity DataIC50:  7.80nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on bovine adrenal zona glomerulosa cell membranes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 2(Bos taurus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013342(CHEMBL3349625)
Affinity DataIC50:  8.70nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on bovine adrenal zona glomerulosa cell membranes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192889(CHEMBL3975359)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192880(CHEMBL3984425 | US10329299, Compound 21 | US106752...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033456((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[(S)-2-cycloh...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033477((S)-2-{(S)-2-[(S)-2-((S)-2-{(S)-2-[(2-Benzyl-3-phe...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033462((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-3-methyl-2-[(S)...)
Affinity DataIC50:  24nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192882(CHEMBL3937119)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 2(Bos taurus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50013339(CHEMBL3349627)
Affinity DataIC50:  29nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on bovine adrenal zona glomerulosa cell membranes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033461((S)-N-((S)-1-Hydroxymethyl-3,3-dimethyl-butyl)-3-(...)
Affinity DataIC50:  34nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033449((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[(S)-3,3-dime...)
Affinity DataIC50:  36nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192899(CHEMBL3963736)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033455((S)-2-((S)-3-Carboxy-2-{(S)-2-[(S)-2-(2-ethyl-buty...)
Affinity DataIC50:  43nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192883(CHEMBL3976330)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 2(Bos taurus)
Bio Mega Laboratories

Curated by ChEMBL
LigandPNGBDBM50228712(CHEMBL3350078)
Affinity DataIC50:  51nMAssay Description:Binding affinity was determined based on the displacement of [125]r-ANF (99-126) from binding sites on bovine adrenal zona glomerulosa cell membranes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192901(CHEMBL3911278)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50369049(CHEMBL1790855)
Affinity DataIC50:  61nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192885(CHEMBL3923629 | US10329299, Compound 54 | US106752...)
Affinity DataIC50:  75nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130245(6,8-Dichloro-7-cyclopropylmethoxy-9H-beta-carbolin...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192881(CHEMBL3914602 | US10329299, Compound 30 | US106752...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130248(CHEMBL79004 | N-(6-Chloro-9H-beta-carbolin-8-yl)-n...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192888(CHEMBL3947903)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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