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Found 490 with Last Name = 'guida' and Initial = 'wc'
TargetThymidine phosphorylase(Homo sapiens (Human))
Attenuon

Curated by ChEMBL
LigandPNGBDBM50121753(1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin...)
Affinity DataKi:  5nMAssay Description:Binding affinity towards recombinant thymidine phosphorylase TPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Mus musculus)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039549(3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyri...)
Affinity DataKi:  5nMAssay Description:Binding affinity against Purine nucleoside Phosphorylase from calf spleenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033666(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Affinity DataKi:  8.70nMAssay Description:Binding affinity against hydrophobic pocket of Purine nucleoside PhosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033666(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Affinity DataKi:  8.70nMAssay Description:Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033666(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Affinity DataKi:  8.70nMAssay Description:Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046234(2-Amino-7-benzyl-3,4a,5,7a-tetrahydro-pyrrolo[3,2-...)
Affinity DataKi:  12nMAssay Description:Inhibition of purine nucleoside phosphorylase against the enzyme from calf spleen in 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046239(2-Amino-9-thiophen-3-ylmethyl-1,9-dihydro-purin-6-...)
Affinity DataKi:  15nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046215(2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-puri...)
Affinity DataKi:  45nMAssay Description:Inhibition of purine nucleoside phosphorylase against the enzyme from calf spleen in 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046215(2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-puri...)
Affinity DataKi:  90nMAssay Description:Inhibition of purine nucleoside phosphorylase against the enzyme from calf spleen in 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046234(2-Amino-7-benzyl-3,4a,5,7a-tetrahydro-pyrrolo[3,2-...)
Affinity DataKi:  100nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039559(CHEMBL267803 | [5-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  170nMAssay Description:Inhibition of human erythrocytic PNP (purine nucleoside phosphorylase) in 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039552(CHEMBL267312 | [3,3-Dimethyl-5-(6-oxo-1,6-dihydro-...)
Affinity DataKi:  210nMAssay Description:Inhibition of human erythrocytic PNP (purine nucleoside phosphorylase) in 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Affinity DataKi:  220nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Affinity DataKi:  300nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039555(CHEMBL13130 | [5-(6-Oxo-1,6-dihydro-purin-9-yl)-pe...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of human erythrocytic PNP (purine nucleoside phosphorylase) in 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046226(2-Amino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Attenuon

Curated by ChEMBL
LigandPNGBDBM50121756((benzylamino)[(2,4-dioxo-1,2,3,4-tetrahydrothieno[...)
Affinity DataKi:  6.43E+4nMAssay Description:Binding affinity towards recombinant thymidine phosphorylase TPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Attenuon

Curated by ChEMBL
LigandPNGBDBM50121754(CHEMBL12488 | amino[(2,4-dioxo-1,2,3,4-tetrahydrot...)
Affinity DataKi:  7.60E+4nMAssay Description:Binding affinity towards recombinant thymidine phosphorylase TPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041099(9-(3,3-Dimethyl-pentyl)-1,9-dihydro-purin-6-one | ...)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibition of human erythrocytic PNP (purine nucleoside phosphorylase) in 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Attenuon

Curated by ChEMBL
LigandPNGBDBM50121757(6-Amino-1H-thieno[3,2-d]pyrimidine-2,4-dione | CHE...)
Affinity DataKi: >3.00E+5nMAssay Description:Binding affinity towards recombinant thymidine phosphorylase TPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Attenuon

Curated by ChEMBL
LigandPNGBDBM50121755(7-Amino-1H-thieno[3,2-d]pyrimidine-2,4-dione | CHE...)
Affinity DataKi: >6.00E+5nMAssay Description:Binding affinity towards recombinant thymidine phosphorylase TPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Attenuon

Curated by ChEMBL
LigandPNGBDBM50121758(CHEMBL274649 | amino[(2,4-dioxo-1,2,3,4-tetrahydro...)
Affinity DataKi: >2.40E+6nMAssay Description:Binding affinity towards recombinant thymidine phosphorylase TPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046227(2-Amino-6-thiophen-2-ylmethyl-3,7-dihydro-pyrrolo[...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046231(2-Amino-6-furan-2-ylmethyl-3,7-dihydro-pyrrolo[3,2...)
Affinity DataIC50:  0.0570nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046239(2-Amino-9-thiophen-3-ylmethyl-1,9-dihydro-purin-6-...)
Affinity DataIC50:  0.0670nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046249(2-Amino-6-thiophen-3-ylmethyl-3,7-dihydro-pyrrolo[...)
Affinity DataIC50:  0.0670nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046252(2-Amino-6-benzyl-3,7-dihydro-pyrrolo[3,2-d]pyrimid...)
Affinity DataIC50:  0.0850nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046224(2-Amino-8-[(thiophen-3-ylmethyl)-amino]-1,9-dihydr...)
Affinity DataIC50:  0.0850nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046229(2-Amino-6-pyridin-3-yl-3,7-dihydro-pyrrolo[3,2-d]p...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046246(2-Amino-8-[(thiophen-2-ylmethyl)-amino]-1,9-dihydr...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046215(2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-puri...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of purine nucleoside phosphorylase against the enzyme from calf spleen in 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046241(2-Amino-8-[(furan-2-ylmethyl)-amino]-1,9-dihydro-p...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046251(2-Amino-8-benzylamino-1,9-dihydro-purin-6-one | CH...)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM25470(N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]-2,3-dihydro-...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of N-terminal GST-tagged ROCK2 (1 to 552) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046221(2-Amino-6-[(thiophen-3-ylmethyl)-amino]-3,7-dihydr...)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046238(2,8-Diamino-9-thiophen-3-ylmethyl-1,9-dihydro-puri...)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of purine nucleoside phosphorylase against the enzyme from calf spleen in 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046216(2-Amino-6-[(furan-2-ylmethyl)-amino]-3,7-dihydro-p...)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046223(2-Amino-6-benzylamino-3,7-dihydro-pyrrolo[3,2-d]py...)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50: <1nMAssay Description:Inhibition of TBK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N1(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50: <1nMAssay Description:Inhibition of PKN1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50: <1nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50: <1nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50: <1nMAssay Description:Inhibition of IKKepsilon (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046243(2-Amino-6-[(thiophen-2-ylmethyl)-amino]-3,7-dihydr...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50: <1nMAssay Description:Inhibition of p70S6K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50: <1nMAssay Description:Inhibition of Aurora-A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of LIMK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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