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Found 174 with Last Name = 'guss' and Initial = 'vl'
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50485806(CHEMBL2164125)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of human gamma-secretase expressed in IMR32 cell membranes using MBPC-125 Swedish as substrate assessed as inhibition of amyloid beta40 pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477513(CHEMBL392246)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477923(CHEMBL437977)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477516(BMS-433796 | CHEMBL247361)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM29012(N-[(4R)-4-{[5-chloro-2-(hydroxymethyl)phenyl](4-ch...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477528(CHEMBL397844)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477531(CHEMBL396808)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM29013(4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]-N-[(...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477936(CHEMBL252052)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477536(CHEMBL247155)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477922(CHEMBL252051)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477915(CHEMBL252846)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477526(CHEMBL429292)
Affinity DataIC50:  1nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477521(CHEMBL439210)
Affinity DataIC50:  1nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477917(CHEMBL253295)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477945(CHEMBL429838)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477517(CHEMBL246785)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477932(CHEMBL253091)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477534(CHEMBL397394)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477511(CHEMBL245385)
Affinity DataIC50:  2nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477519(CHEMBL397335)
Affinity DataIC50:  2nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477715(CHEMBL248647)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of gamma-secretase assessed as reduction of amyloid-beta 42 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477715(CHEMBL248647)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of gamma-secretase assessed as reduction of amyloid-beta 40 levels in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477939(CHEMBL253092)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477530(CHEMBL246575)
Affinity DataIC50:  3nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477933(CHEMBL253041)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477524(CHEMBL246784)
Affinity DataIC50:  4nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50476941(CHEMBL233363)
Affinity DataIC50:  4nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477715(CHEMBL248647)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta40 production after 19 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477943(CHEMBL437405)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50476940(CHEMBL233362)
Affinity DataIC50:  5nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477702(CHEMBL398975)
Affinity DataIC50:  5nMAssay Description:Inhibition of gamma-secretase assessed as reduction of amyloid-beta 40 levels in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50476939(CHEMBL233364)
Affinity DataIC50:  5nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50476940(CHEMBL233362)
Affinity DataIC50:  5nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477929(CHEMBL253283)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477925(CHEMBL251856)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477533(CHEMBL246369)
Affinity DataIC50:  6nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477921(CHEMBL404294)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477937(CHEMBL253727)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477940(CHEMBL252305)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50476947(CHEMBL394661)
Affinity DataIC50:  7nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477942(CHEMBL252303)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477912(CHEMBL253296)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477697(CHEMBL250200)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of gamma-secretase assessed as reduction of amyloid-beta 42 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477535(CHEMBL397547)
Affinity DataIC50:  8nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477927(CHEMBL252304)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477686(CHEMBL251416)
Affinity DataIC50:  9nMAssay Description:Inhibition of gamma-secretase assessed as reduction of amyloid-beta 40 levels in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477518(CHEMBL436997)
Affinity DataIC50:  9nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477683(CHEMBL250820)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of gamma-secretase assessed as reduction of amyloid-beta 40 levels in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477685(CHEMBL401386)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of gamma-secretase assessed as reduction of amyloid-beta 40 levels in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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