Found 1124 with Last Name = 'haggarty' and Initial = 'sj' TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataKi: <0.200nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair
3D Structure (crystal)TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataKi: 84nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataKi: 176nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataKi: 500nMAssay Description:Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptid...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataKi: 519nMAssay Description:Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataKi: 2.08E+3nMAssay Description:Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptid...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant HDAC6 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant HDAC1 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant HDAC6 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant HDAC1 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant HDAC3 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Momoamine oxidase type B(MAO-B) activity in vitro assay using molecules that caused a photomotor response (PMR) "magnitude stimulant' (MAG) pheno...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant HDAC2 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant HDAC1 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant HDAC3 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant HDAC3 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant HDAC1 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant HDAC3 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant HDAC3 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant HDAC3 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptid...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant HDAC6 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylat...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human recombinant HDAC2 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human recombinant HDAC1 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant HDAC1 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human recombinant HDAC3 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human recombinant HDAC1 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human recombinant HDAC1 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human recombinant HDAC3 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:The following non-trypsin coupled in-vitro HDAC enzymatic endpoint assay was used to assay the compounds of the invention. Below is a standardized pr...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant HDAC2 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human recombinant HDAC3 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:The following non-trypsin coupled in-vitro HDAC enzymatic endpoint assay was used to assay the compounds of the invention. Below is a standardized pr...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human recombinant HDAC2 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human recombinant HDAC2 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant HDAC1 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human full length TNIK(1-1360)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubated...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant HDAC1 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Broad Institute Of Mit And Harvard
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:The following non-trypsin coupled in-vitro HDAC enzymatic endpoint assay was used to assay the compounds of the invention. Below is a standardized pr...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human 6His-TEV-TNIK(1 to 325) expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followe...More data for this Ligand-Target Pair
