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Found 710 with Last Name = 'hashimoto' and Initial = 'h'
TargetTissue alpha-L-fucosidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104398((R)-2-Methyl-6-(4-nitro-phenylsulfanyl)-tetrahydro...)
Affinity DataKi:  3.30E+3nMAssay Description:Compound was tested for the inhibitory activity against alpha-L-fucosidase from bovine epididymisMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein-arginine deiminase type-1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50355656(CHEMBL1910970)
Affinity DataKi:  9.40E+3nMAssay Description:Irreversible inhibition of PAD1 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluoromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-arginine deiminase type-4(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50355665(CHEMBL1910971)
Affinity DataKi:  1.30E+4nMAssay Description:Irreversible inhibition of PAD4 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluoromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-arginine deiminase type-4(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50355656(CHEMBL1910970)
Affinity DataKi:  1.60E+4nMAssay Description:Irreversible inhibition of PAD4 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluoromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-arginine deiminase type-3(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50355657(CHEMBL1910972 | CHEMBL1962361)
Affinity DataKi:  2.80E+4nMAssay Description:Irreversible inhibition of PAD3 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluoromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-arginine deiminase type-3(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50355665(CHEMBL1910971)
Affinity DataKi:  2.90E+4nMAssay Description:Irreversible inhibition of PAD3 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluoromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue alpha-L-fucosidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287679(CHEMBL61555 | Sodium; benzyl 3,4,5-trihydroxy-6-me...)
Affinity DataKi:  3.30E+4nMAssay Description:Compound was tested for the inhibitory activity against alpha-L-fucosidase from bovine epididymisMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue alpha-L-fucosidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104411((R)-6-Methyl-tetrahydro-thiopyran-2,3,4,5-tetraol ...)
Affinity DataKi:  4.20E+4nMAssay Description:Compound was tested for the inhibitory activity against alpha-L-fucosidase from bovine epididymisMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein-arginine deiminase type-1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50355657(CHEMBL1910972 | CHEMBL1962361)
Affinity DataKi:  6.20E+4nMAssay Description:Irreversible inhibition of PAD1 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluoromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-arginine deiminase type-1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50355658(CHEMBL1910973)
Affinity DataKi:  1.10E+5nMAssay Description:Irreversible inhibition of PAD1 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluoromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue alpha-L-fucosidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287680((3R,4S,5S)-2-Methyl-6-(4-nitro-phenoxy)-tetrahydro...)
Affinity DataKi:  1.18E+5nMAssay Description:Compound was tested for the inhibitory activity against alpha-L-fucosidase from bovine epididymisMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein-arginine deiminase type-4(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50355657(CHEMBL1910972 | CHEMBL1962361)
Affinity DataKi:  1.80E+5nMAssay Description:Irreversible inhibition of PAD4 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluoromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue alpha-L-fucosidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287682((3S,4S,5R)-2-Cyclohexyloxy-6-methyl-tetrahydro-thi...)
Affinity DataKi:  1.98E+5nMAssay Description:Compound was tested for the inhibitory activity against alpha-L-fucosidase from bovine epididymisMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein-arginine deiminase type-3(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50355658(CHEMBL1910973)
Affinity DataKi:  2.93E+5nMAssay Description:Irreversible inhibition of PAD3 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluoromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-arginine deiminase type-4(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50355658(CHEMBL1910973)
Affinity DataKi:  3.30E+5nMAssay Description:Irreversible inhibition of PAD4 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluoromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue alpha-L-fucosidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287681(CHEMBL59958 | Sodium; Phosphoric acid mono-((3S,4S...)
Affinity DataKi:  4.06E+5nMAssay Description:Compound was tested for the inhibitory activity against alpha-L-fucosidase from bovine epididymisMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue alpha-L-fucosidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287683((3S,4S,5R)-2-Methoxy-6-methyl-tetrahydro-thiopyran...)
Affinity DataKi:  6.90E+5nMAssay Description:Compound was tested for the inhibitory activity against alpha-L-fucosidase from bovine epididymisMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue alpha-L-fucosidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287678((3R,4S,5S)-2-Methyl-6-methylsulfanyl-tetrahydro-th...)
Affinity DataKi:  2.30E+6nMAssay Description:Compound was tested for the inhibitory activity against alpha-L-fucosidase from bovine epididymisMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of N-terminal GST-fused human JAK2 (880 to end residues) expressed in baculovirus infected Sf21 cells using TK-substrate-biotin as substra...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of N-terminal GST-fused human JAK2 (880 to end residues) expressed in baculovirus infected Sf21 cells using TK-substrate-biotin as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of N-terminal GST-fused human JAK1 (850 to 1154 residues) expressed in baculovirus expression system using TK-substrate-biotin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of N-terminal GST-fused human JAK1 (850 to 1154 residues) expressed in baculovirus expression system using TK-substrate-biotin as substrat...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532190(CHEMBL4452717)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5)
Affinity DataIC50:  6nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM109863(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM109863(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532193(CHEMBL4539279)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50370763(CHEMBL1203926)
Affinity DataIC50:  9nMAssay Description:Inhibition of HCV NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50503530(CHEMBL4437645)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50503530(CHEMBL4437645)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM109907(US8609647, 52)
Affinity DataIC50:  10nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532178(CHEMBL4460662)
Affinity DataIC50:  10nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM109866(US8609647, 26 | US8609647, 4)
Affinity DataIC50:  11nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532197(CHEMBL4522278)
Affinity DataIC50:  11nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM109866(US8609647, 26 | US8609647, 4)
Affinity DataIC50:  11nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191541(2-[4-(4'-chloro-4-methylcarbamoylbiphenyl-2-ylmeth...)
Affinity DataIC50:  12nMAssay Description:Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191533(2-[4-(4'-chloro-4-dimethylcarbamoylbiphenyl-2-ylme...)
Affinity DataIC50:  12nMAssay Description:Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532180(CHEMBL4473704)
Affinity DataIC50:  12nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532183(CHEMBL4543929)
Affinity DataIC50:  12nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532194(CHEMBL4575001)
Affinity DataIC50:  12nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50110994(4-[2-Methyl-4-(5-methyl-thiophen-2-yl)-oxazol-5-yl...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human purified Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191549(2-[4-(4'-chloro-4-isopropylcarbamoylbiphenyl-2-ylm...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532188(CHEMBL4570496)
Affinity DataIC50:  13nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532195(CHEMBL4555993)
Affinity DataIC50:  13nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191505(2-[4-(4-carbamoyl-4'-chlorobiphenyl-2-ylmethoxy)ph...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158838(2-{4-[2-(4-chlorophenyl)-5-(4-hydroxyhexahydro-1-p...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191508(2-{4-[4'-chloro-4-(morpholine-4-carbonyl)biphenyl-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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