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Found 40 with Last Name = 'hatse' and Initial = 's'
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50270276(CHEMBL477121 | N-[1,4,8,11-Tetraazacyclotetradecan...)
Affinity DataKi:  10nMAssay Description:Antagonist activity at human wild type CXCR4 expressed in COS7 cells coexpressing G protein Gqi4myr assessed as inhibition of CXCL12-induced phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50270276(CHEMBL477121 | N-[1,4,8,11-Tetraazacyclotetradecan...)
Affinity DataKi:  110nMAssay Description:Displacement of [125I]12G5 antibody from human wild type CXCR4 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50035696(1,1''-{1,4-phenylenebis(methylene)}-bis{1,4,8,11-t...)
Affinity DataKi:  220nMAssay Description:Antagonist activity at human wild type CXCR4 expressed in COS7 cells coexpressing G protein Gqi4myr assessed as inhibition of CXCL12-induced phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50035696(1,1''-{1,4-phenylenebis(methylene)}-bis{1,4,8,11-t...)
Affinity DataKi:  890nMAssay Description:Displacement of [125I]12G5 antibody from human wild type CXCR4 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50270277(Benzyl-[4-(1,4,8,11tetraaza-cyclotetradec-1-ylmeth...)
Affinity DataKi:  1.70E+3nMAssay Description:Antagonist activity at human wild type CXCR4 expressed in COS7 cells coexpressing G protein Gqi4myr assessed as inhibition of CXCL12-induced phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50035719(1-(4-Methyl-benzyl)-1,4,8,11tetraaza-cyclotetradec...)
Affinity DataKi:  2.00E+4nMAssay Description:Antagonist activity at human wild type CXCR4 expressed in COS7 cells coexpressing G protein Gqi4myr assessed as inhibition of CXCL12-induced phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315287((R)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(5,6,...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315305((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-amin...)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315287((R)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(5,6,...)
Affinity DataIC50:  22nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315290(CHEMBL1093008 | N-[(1H-Benzo[d]midazol-2-yl)methyl...)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315295(CHEMBL1088912 | N1-(1H-Benzo[d]imidazol-2-ylmethyl...)
Affinity DataIC50:  68nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315297(CHEMBL1088916 | N1-(1H-Benzo[d]imidazol-2-ylmethyl...)
Affinity DataIC50:  75nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315291((Z)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,...)
Affinity DataIC50:  77nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315298(CHEMBL1092301 | N1-(1H-Benzo[d]imidazol-2-ylmethyl...)
Affinity DataIC50:  87nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315288(CHEMBL1092324 | N-[(1H-Benzo[d]imidazol-2-yl)methy...)
Affinity DataIC50:  119nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315303((S)-N-(2-Pyridinylmethyl)-N'-(1H-benzimidazol-2-yl...)
Affinity DataIC50:  120nMAssay Description:Inhibition of anti-CXCR4 12G5 monoclonal antibody to CXCR4 in human SUP-T1 cells pretreated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315292((E)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,...)
Affinity DataIC50:  160nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315299(CHEMBL1092302 | N1-(1H-Benzo[d]imidazol-2-ylmethyl...)
Affinity DataIC50:  190nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315287((R)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(5,6,...)
Affinity DataIC50:  206nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315302(CHEMBL1089434 | N-(2-Pyridinylmethyl)-N'-(1H-benzi...)
Affinity DataIC50:  250nMAssay Description:Inhibition of anti-CXCR4 12G5 monoclonal antibody to CXCR4 in human SUP-T1 cells pretreated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315300(5-(((1H-Benzo[d]imidazol-2-yl)methyl)(5,6,7,8-tetr...)
Affinity DataIC50:  442nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315296(CHEMBL1092596 | N1-(1H-Benzo[d]imidazol-2-ylmethyl...)
Affinity DataIC50:  514nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315293(CHEMBL1089846 | N1-(1H-Benzo[d]imidazol-2-ylmethyl...)
Affinity DataIC50:  973nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315294(CHEMBL1093302 | N1-(1H-Benzo[d]imidazol-2-ylmethyl...)
Affinity DataIC50:  1.37E+3nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315289(CHEMBL1088867 | N-[(1H-Benzo[d]midazol-2-yl)methyl...)
Affinity DataIC50:  1.40E+3nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315301(CHEMBL1092629 | N-((1H-Benzo[d]imidazol-2-yl)methy...)
Affinity DataIC50:  3.20E+3nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50315305((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled MIP1alpha from CCR1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50315305((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled IL8 from CXCR2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50315303((S)-N-(2-Pyridinylmethyl)-N'-(1H-benzimidazol-2-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled MIP1alpha from CCR1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50315303((S)-N-(2-Pyridinylmethyl)-N'-(1H-benzimidazol-2-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled MCP1 from CCR2b receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50315305((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled MCP1 from CCR2b receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50315303((S)-N-(2-Pyridinylmethyl)-N'-(1H-benzimidazol-2-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled TARC from CCR4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50315305((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled TARC from CCR4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50315303((S)-N-(2-Pyridinylmethyl)-N'-(1H-benzimidazol-2-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled MIP1beta from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50315305((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled MIP1beta from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50315303((S)-N-(2-Pyridinylmethyl)-N'-(1H-benzimidazol-2-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50315305((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50315303((S)-N-(2-Pyridinylmethyl)-N'-(1H-benzimidazol-2-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled IL8 from CXCR2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50315304((R)-N-(2-Pyridinylmethyl)-N'-(1H-benzimidazol-2-yl...)
Affinity DataIC50:  2.92E+4nMAssay Description:Inhibition of anti-CXCR4 12G5 monoclonal antibody to CXCR4 in human SUP-T1 cells pretreated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 5(Homo sapiens (Human))
The Netherlands Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50237626(Anturan | Anturane | CHEBI:9342 | Sulfinpyrazone |...)
Affinity DataIC50: <1.00E+5nMAssay Description:TP_TRANSPORTER: inhibition of PMEA efflux (PMEA: 1 uM) in MRP5-expressing MDCKII cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed