Compile Data Set for Download or QSAR
maximum 50k data
Found 3376 with Last Name = 'helal' and Initial = 'cj'
LigandPNGBDBM50398003(CHEMBL2180402)
Affinity DataKi:  0.100nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398003(CHEMBL2180402)
Affinity DataKi:  0.100nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398012(CHEMBL2180422 | US8492392, 1-17)
Affinity DataKi:  0.630nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398013(CHEMBL2180421 | US8492392, K-2)
Affinity DataKi:  0.900nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398011(CHEMBL2180423 | US8492392, O-2)
Affinity DataKi:  0.920nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398004(CHEMBL2180401)
Affinity DataKi:  0.950nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398008(CHEMBL2180426)
Affinity DataKi:  2nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM119778(CHEMBL2180429 | US8691827, I-9)
Affinity DataKi:  2.20nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM107767(US11419874, PF-05180999 | US8598155, 2)
Affinity DataKi:  4.20nMAssay Description:Displacement of radiolabeled 4-(azetidin-1-yl)-3-[5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]-1-(tritritiomethyl)pyrazolo[3,4-d]pyrimidine from PD...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398005(CHEMBL2180430 | US8691827, I-8)
Affinity DataKi:  15nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398007(CHEMBL2180428 | US8691827, I-1)
Affinity DataKi:  48nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398010(CHEMBL2180424)
Affinity DataKi:  87nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50088503(CHEMBL3527048)
Affinity DataKi:  120nMAssay Description:Inhibition of midazolam 1'-hydroxylase activity of human recombinant CYP3A4 harboring human P450 oxidoreductase and b5 assessed as decrease in enzyme...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50088503(CHEMBL3527048)
Affinity DataKi:  170nMAssay Description:Inhibition of testosterone 6beta-hydroxylase activity of human recombinant CYP3A4 in presence of human P450 oxidoreductase and b5 assessed as decreas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398789(CHEMBL2180073)
Affinity DataKi:  293nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003985(CHEMBL2180436)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003983(CHEMBL2180435)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003984(CHEMBL2180437)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003980(CHEMBL2180434)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003979(CHEMBL2180433)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003981(CHEMBL2180431)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003982(CHEMBL2180432)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50088503(CHEMBL3527048)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of testosterone 6beta-hydroxylase activity of human recombinant CYP3A5 in presence of human P450 oxidoreductase and b5 assessed as decreas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398807(CHEMBL2180074)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398009(CHEMBL2180425)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50088503(CHEMBL3527048)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of midazolam 1'-hydroxylase activity of human recombinant CYP3A5 harboring human P450 oxidoreductase and b5 assessed as decrease in enzyme...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398800(CHEMBL2180069)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398804(CHEMBL2177497)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397973(CHEMBL2180441)
Affinity DataIC50:  0.00330nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM160666(US9045498, 8)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[oregon green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50259962(CHEMBL4088234)
Affinity DataIC50:  0.0240nMAssay Description:Inhibition of BACE1 in human H4 cells expressing wild type APP695 assessed as reduction in soluble APPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM142586(US8933224, 4)
Affinity DataIC50:  0.0386nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM142493(US8933224, 86)
Affinity DataIC50:  0.0444nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50397987(CHEMBL2180452)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer

US Patent
LigandPNGBDBM142557(US8933224, 150)
Affinity DataIC50:  0.0697nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM142544(US8933224, 137)
Affinity DataIC50:  0.0777nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer

US Patent
LigandPNGBDBM142550(US8933224, 143 | US8933224, 144)
Affinity DataIC50:  0.0837nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer

US Patent
LigandPNGBDBM142481(US8933224, 74)
Affinity DataIC50:  0.0896nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer

US Patent
LigandPNGBDBM142544(US8933224, 137)
Affinity DataIC50:  0.0950nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer

US Patent
LigandPNGBDBM142536(US8933224, 129)
Affinity DataIC50:  0.0998nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50004081(CHEMBL2180797)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of PDEDA2 using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397999(CHEMBL2180796)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of PDEDA2 using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer

US Patent
LigandPNGBDBM142459(US8933224, 52)
Affinity DataIC50:  0.101nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer

US Patent
LigandPNGBDBM142451(US8933224, 44)
Affinity DataIC50:  0.102nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer

US Patent
LigandPNGBDBM142550(US8933224, 143 | US8933224, 144)
Affinity DataIC50:  0.106nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM142451(US8933224, 44)
Affinity DataIC50:  0.110nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer

US Patent
LigandPNGBDBM142442(US8933224, 35)
Affinity DataIC50:  0.123nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer

US Patent
LigandPNGBDBM142555(US8933224, 148)
Affinity DataIC50:  0.125nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer

US Patent
LigandPNGBDBM142559(US8933224, 152)
Affinity DataIC50: <0.130nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer

US Patent
LigandPNGBDBM142493(US8933224, 86)
Affinity DataIC50:  0.132nMpH: 7.5Assay Description:The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Displayed 1 to 50 (of 3376 total ) | Next | Last >>
Jump to: