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Found 1290 with Last Name = 'holson' and Initial = 'e'
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi: <0.200nM ΔG°: <-55.4kJ/mole IC50:  1nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi: <0.200nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi:  1.5nM ΔG°:  -50.4kJ/mole IC50:  13nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi:  1.5nMAssay Description:Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/mole IC50:  2nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  14nM ΔG°:  -44.8kJ/mole IC50:  19nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19422(4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-...)
Affinity DataKi:  25nM ΔG°:  -43.4kJ/mole IC50:  46nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178100(BRD3308 | US11377423, Cmpd 1)
Affinity DataKi:  29nM ΔG°:  -43.0kJ/mole IC50:  64nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19422(4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-...)
Affinity DataKi:  37nM ΔG°:  -42.4kJ/mole IC50:  41nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457880(US10752588, Compound 94a)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457876(US10752588, Compound 63)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457879(US10752588, Compound 95)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457899(US10752588, Compound 125)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457881(US10752588, Compound 94b)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457883(US10752588, Compound 42)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457884(US10752588, Compound 79)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457885(US10752588, Compound 79b)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457886(US10752588, Compound 114)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457887(US10752588, Compound 114a)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457889(US10752588, Compound 72 | US10752588, Compound 72a)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457891(US10752588, Compound 77a)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457892(US10752588, Compound 66)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457894(US10752588, Compound 6)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457896(US10752588, Compound 92)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457897(US10752588, Compound 53)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457898(US10752588, Compound 69b)
Affinity DataKi:  55nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM50189903(CHEMBL3828396 | US11572368, Compound 54)
Affinity DataKi:  84nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM580141(US11498896, Compound 106)
Affinity DataKi: <100nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM580142(US11498896, Compound 110)
Affinity DataKi: <100nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM580146(US11498896, Compound 123)
Affinity DataKi: <100nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM580148(US11498896, Compound 135)
Affinity DataKi: <100nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM580149(US11498896, Compound 137)
Affinity DataKi: <100nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM580162(US11498896, Compound 211)
Affinity DataKi: <100nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi: <100nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457888(US10752588, Compound 105)
Affinity DataKi: <100nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457889(US10752588, Compound 72 | US10752588, Compound 72a)
Affinity DataKi: <100nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM457901(US10752588, Compound 144a)
Affinity DataKi: <100nMAssay Description:radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi: <100nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM580132(US11498896, Compound 86)
Affinity DataKi: <100nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM580136(US11498896, Compound 98a)
Affinity DataKi: <100nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM50189911(CHEMBL3827611)
Affinity DataKi:  176nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19422(4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-...)
Affinity DataKi:  223nM ΔG°:  -38.0kJ/mole IC50:  147nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi:  500nM ΔG°:  -36.0kJ/mole IC50:  398nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi:  500nMAssay Description:Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM50189911(CHEMBL3827611)
Affinity DataKi:  519nMAssay Description:Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM580152(US11498896, Compound 157)
Affinity DataKi:  550nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM580155(US11498896, Compound 204b)
Affinity DataKi:  550nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM580157(US11498896, Compound 205)
Affinity DataKi:  550nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM580158(US11498896, Compound 206)
Affinity DataKi:  550nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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