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Found 231 with Last Name = 'huby' and Initial = 'n'
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041293(1-(8-Methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]...)
Affinity DataKi:  0.121nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041293(1-(8-Methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]...)
Affinity DataKi:  0.394nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041304(1-(8-Methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041294(1-(3-Biphenyl-4-yl-8-methyl-8-aza-bicyclo[3.2.1]oc...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041300(1-(8-Methyl-3-naphthalen-1-yl-8-aza-bicyclo[3.2.1]...)
Affinity DataKi:  21nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041298(1-(8-Methyl-3-naphthalen-1-yl-8-aza-bicyclo[3.2.1]...)
Affinity DataKi:  26nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041303(1-[3-(4-Isopropyl-phenyl)-8-methyl-8-aza-bicyclo[3...)
Affinity DataKi:  36nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041307(1-[3-(4-Ethyl-phenyl)-8-methyl-8-aza-bicyclo[3.2.1...)
Affinity DataKi:  78nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041299(1-(8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]oct-2-yl...)
Affinity DataKi:  122nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041296(1-(8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]oct-2-yl...)
Affinity DataKi:  131nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041296(1-(8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]oct-2-yl...)
Affinity DataKi:  131nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041306(1-[3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2....)
Affinity DataKi:  630nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041295(1-[3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2....)
Affinity DataKi:  857nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041297(1-(8-Methyl-3-phenyl-8-aza-bicyclo[3.2.1]oct-2-yl)...)
Affinity DataKi:  1.01E+3nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041302(1-(8-Methyl-3-phenyl-8-aza-bicyclo[3.2.1]oct-2-yl)...)
Affinity DataKi:  1.36E+3nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041310(1-[3-(4-tert-Butyl-phenyl)-8-methyl-8-aza-bicyclo[...)
Affinity DataKi:  1.77E+3nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041309(1-(3-Ethyl-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl)-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041305(1-(8-Methyl-3-o-tolyl-8-aza-bicyclo[3.2.1]oct-2-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041301(1-(3-Cyclohexyl-8-methyl-8-aza-bicyclo[3.2.1]oct-2...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041293(1-(8-Methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]...)
Affinity DataIC50:  0.0430nMAssay Description:Inhibition of [125I]RTI-55 binding to dopamine transport sites in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117037((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-({1...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117004((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of Very late antigen 4/vascular cell adhesion molecule 1 interaction in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041293(1-(8-Methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]...)
Affinity DataIC50:  0.115nMAssay Description:Inhibition of [125I]RTI-55 binding to dopamine transport sites in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117041((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-({1...)
Affinity DataIC50:  0.140nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117036((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of Very late antigen 4/vascular cell adhesion molecule 1 interaction in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117016((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of Very late antigen 4/vascular cell adhesion molecule 1 interaction in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117026((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.260nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041304(1-(8-Methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]...)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of [125I]RTI-55 binding to dopamine transport sites in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50116998((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of Very late antigen 4/vascular cell adhesion molecule 1 interaction in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117011((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.320nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in RamosMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117028((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.330nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117006((S)-2-{[1-(2-Acetylamino-ethyl)-cyclopentanecarbon...)
Affinity DataIC50:  0.370nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50087594((S)-2-[(1-Benzyl-5-oxo-pyrrolidine-2-carbonyl)-ami...)
Affinity DataIC50:  0.370nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAM by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117031((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-({1...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117000((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-({1...)
Affinity DataIC50:  0.420nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117007((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.460nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117034((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-({1...)
Affinity DataIC50:  0.470nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117017((S)-2-{[1-(4-Cyano-benzyl)-cyclopentanecarbonyl]-a...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in RamosMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117042((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117015((S)-2-{[1-(4-Cyano-butyl)-cyclopentanecarbonyl]-am...)
Affinity DataIC50:  0.520nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117023((S)-2-{[1-(2-Azido-ethyl)-cyclopentanecarbonyl]-am...)
Affinity DataIC50:  0.530nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117022((S)-2-[(1-But-3-enyl-cyclopentanecarbonyl)-amino]-...)
Affinity DataIC50:  0.550nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117038((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117005((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.610nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in RamosMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117029((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-({1...)
Affinity DataIC50:  0.640nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50087612((S)-2-[(1-Benzyl-5-oxo-pyrrolidine-2-carbonyl)-ami...)
Affinity DataIC50:  0.740nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAM by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50087620((S)-2-[(1-Benzyl-5-oxo-pyrrolidine-2-carbonyl)-ami...)
Affinity DataIC50:  0.75nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAM by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117024((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in RamosMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50117008((S)-3-[4-(2,6-Dichloro-benzoylamino)-phenyl]-2-{[1...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50087599((S)-2-[(1-Benzyl-5-oxo-pyrrolidine-2-carbonyl)-ami...)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of human VCAM and Ramos cell VLA-4 interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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