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Found 76 with Last Name = 'huynh' and Initial = 'k'
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503111(CHEMBL4528514 | US11672785, Goodacre Compound 102 ...)
Affinity DataIC50:  0.0794nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as downregulation of ER alpha receptor expression measured after 18 to 22 hrs by immuno...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503109(CHEMBL4591926)
Affinity DataIC50:  0.251nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as downregulation of ER alpha receptor expression measured after 18 to 22 hrs by immuno...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50125052(CHEMBL3623004 | US10130617, Example 1 | US20240043...)
Affinity DataIC50:  0.316nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as downregulation of ER alpha receptor expression measured after 18 to 22 hrs by immuno...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503114(CHEMBL4447306)
Affinity DataIC50:  0.398nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503112(CHEMBL4587197)
Affinity DataIC50:  0.631nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50125052(CHEMBL3623004 | US10130617, Example 1 | US20240043...)
Affinity DataIC50:  0.794nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503110(CHEMBL4452972)
Affinity DataIC50:  0.794nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503111(CHEMBL4528514 | US11672785, Goodacre Compound 102 ...)
Affinity DataIC50:  1nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503109(CHEMBL4591926)
Affinity DataIC50:  1nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503114(CHEMBL4447306)
Affinity DataIC50:  1.30nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as downregulation of ER alpha receptor expression measured after 18 to 22 hrs by immuno...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503112(CHEMBL4587197)
Affinity DataIC50:  1.60nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as downregulation of ER alpha receptor expression measured after 18 to 22 hrs by immuno...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503113(CHEMBL4516412)
Affinity DataIC50:  2nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as downregulation of ER alpha receptor expression measured after 18 to 22 hrs by immuno...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503113(CHEMBL4516412)
Affinity DataIC50:  2nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50091698((2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-c...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cell microsome assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158410(4-((+/-)-(1H-imidazol-1-yl)-N-(imidazolyl)-(E)-ret...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cell microsome assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50091698((2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-c...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cells assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158410(4-((+/-)-(1H-imidazol-1-yl)-N-(imidazolyl)-(E)-ret...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cells assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50091698((2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-c...)
Affinity DataIC50:  10.9nMAssay Description:Inhibition of ATRA-induced CYP26 in human MCF7 cells assessed ATRA as metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503110(CHEMBL4452972)
Affinity DataIC50:  16nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as downregulation of ER alpha receptor expression measured after 18 to 22 hrs by immuno...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158411((2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-c...)
Affinity DataIC50:  24nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cells assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158410(4-((+/-)-(1H-imidazol-1-yl)-N-(imidazolyl)-(E)-ret...)
Affinity DataIC50:  24.7nMAssay Description:Inhibition of ATRA-induced CYP26 in human MCF7 cells assessed ATRA as metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158415(4-((+/-)-(1H-imidazol-1-yl)-(E)-methylretinoate | ...)
Affinity DataIC50:  40nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cell microsome assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158411((2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-c...)
Affinity DataIC50:  56nMAssay Description:Inhibition of ATRA-induced CYP26 in human MCF7 cells assessed ATRA as metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158415(4-((+/-)-(1H-imidazol-1-yl)-(E)-methylretinoate | ...)
Affinity DataIC50:  200nMAssay Description:Inhibition of ATRA-induced CYP26 in human MCF7 cells assessed ATRA as metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158415(4-((+/-)-(1H-imidazol-1-yl)-(E)-methylretinoate | ...)
Affinity DataIC50:  215nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cells assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158414((R,2E,4E,6E,8E)-methyl 9-(3-(1H-imidazol-1-yl)-2,6...)
Affinity DataIC50:  800nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cell microsome assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158414((R,2E,4E,6E,8E)-methyl 9-(3-(1H-imidazol-1-yl)-2,6...)
Affinity DataIC50:  800nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cell microsome assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataIC50:  3.00E+3nMAssay Description:Displacement of [11,12-3H]ARTA from RARbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetFructose-1,6-bisphosphatase 1(Mus musculus)
University Of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50266599((1H-indol-1-yl)(4-(trifluoromethyl)phenyl)methanon...)
Affinity DataIC50:  3.09E+3nMAssay Description:Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Mus musculus)
University Of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50266600(CHEMBL476823 | ethyl 3-(3,5-dimethyl-1H-pyrrol-2-y...)
Affinity DataIC50:  4.81E+3nMAssay Description:Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158414((R,2E,4E,6E,8E)-methyl 9-(3-(1H-imidazol-1-yl)-2,6...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cells assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Mus musculus)
University Of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50266610(3,5-diphenyl-1-(3-(trifluoromethyl)phenyl)-1H-pyra...)
Affinity DataIC50:  6.04E+3nMAssay Description:Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataIC50:  9.00E+3nMAssay Description:Displacement of [11,12-3H]ARTA from RARalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was evaluated for the Selectin E binding activity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Mus musculus)
University Of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50266611(CHEMBL505293 | ethyl 3,3,3-trifluoro-2-hydroxy-2-(...)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Mus musculus)
University Of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50266612(CHEMBL446872 | ethyl 3,3,3-trifluoro-2-hydroxy-2-(...)
Affinity DataIC50:  1.33E+4nMAssay Description:Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158413(CHEMBL388283 | N-(1H-1,2,4-triazol-1-yl)-(E)-retin...)
Affinity DataIC50:  2.00E+4nMAssay Description:Displacement of [11,12-3H]ARTA from RARalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50091698((2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-c...)
Affinity DataIC50:  2.00E+4nMAssay Description:Displacement of [11,12-3H]ARTA from RARalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Mus musculus)
University Of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50266614(CHEMBL503725 | ethyl 3,3,3-trifluoro-2-hydroxy-2-(...)
Affinity DataIC50:  2.57E+4nMAssay Description:Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Mus musculus)
University Of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50266613(CHEMBL517208 | ethyl 4,4,4-trifluoro-3-hydroxy-3-(...)
Affinity DataIC50:  2.57E+4nMAssay Description:Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503110(CHEMBL4452972)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503110(CHEMBL4452972)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503110(CHEMBL4452972)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503110(CHEMBL4452972)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503110(CHEMBL4452972)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Mus musculus)
University Of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50266615(CHEMBL517655 | ethyl 3,3,3-trifluoro-2-hydroxy-2-(...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Mus musculus)
University Of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50266616(CHEMBL505221 | ethyl 4,4,4-trifluoro-3-hydroxy-3-(...)
Affinity DataIC50:  4.18E+4nMAssay Description:Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Mus musculus)
University Of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50266634(3,5-bis(4-fluorophenyl)-1-(3-(trifluoromethyl)phen...)
Affinity DataIC50:  7.55E+4nMAssay Description:Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Mus musculus)
University Of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50266635(1-(phenylsulfonyl)-1H-pyrrole | CHEMBL449256)
Affinity DataIC50:  7.62E+4nMAssay Description:Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50158413(CHEMBL388283 | N-(1H-1,2,4-triazol-1-yl)-(E)-retin...)
Affinity DataIC50:  9.00E+4nMAssay Description:Displacement of [11,12-3H]ARTA from RARbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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