TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:The apparent Km of compound as a substrate for partially purified mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Compound was evaluated for the alpha-Adrenoceptor pA2 blocking activity in vitro in rabbit thoracic aortaMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 8.30nMAssay Description:The apparent Km of compound as a substrate for partially purified mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 8.30nMAssay Description:Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 8.80nMAssay Description:Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 64nMAssay Description:Potent inhibitor of Folyl-polyglutamate synthase obtained from porcineMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 150nMAssay Description:Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 420nMAssay Description:The apparent Km of compound as a substrate for partially purified mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 500nMAssay Description:Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 900nMAssay Description:Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Binding affinity against thymidylate synthase from murine leukemia L1210More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Inhibitory constant of thymidylate synthase was determined in human AML cellsMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 1.20E+3nMAssay Description:The apparent Km of compound as a substrate for partially purified mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 1.40E+3nMAssay Description:potent inhibitor of GAR Tfase obtained from porcineMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 2.80E+3nMAssay Description:The apparent Km of compound as a substrate for partially purified mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 5.90E+3nMAssay Description:The apparent Km of compound as a substrate for partially purified mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 5.90E+3nMAssay Description:Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 5.90E+3nMAssay Description:The apparent Km of compound as a substrate for partially purified mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 5.90E+3nMAssay Description:Binding affinity of the compound for hog liver Folyl-polyglutamate synthase was evaluatedMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 8.30E+3nMAssay Description:Compound was evaluated for its binding affinity against hog liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Binding affinity against human enzyme thymidylate synthase derived from either HeLa or KB cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.00E+4nMAssay Description:Inhibitory constant of thymidylate synthase was determined in human AML cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of rat liver dihydrofolate reductase assayed spectrophotometrically at 340 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of rat liver dihydrofolate reductase assayed spectrophotometrically at 340 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of rat liver dihydrofolate reductase assayed spectrophotometrically at 340 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of rat liver dihydrofolate reductase assayed spectrophotometrically at 340 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of rat liver DHFR assayed spectrophotometrically at 340 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Inhibition of rat liver DHFR assayed spectrophotometrically at 340 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Inhibition of rat liver dihydrofolate reductase assayed spectrophotometrically at 340 nMMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Ability to inhibit thymidylate synthase derived from human leukemia K562 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Ability to inhibit thymidylate synthase derived from human leukemia K562 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMAssay Description:Ability to inhibit thymidylate synthase derived from human leukemia K562 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Ability to inhibit thymidylate synthase derived from human leukemia K562 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Ability to inhibit thymidylate synthase derived from human leukemia K562 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Ability to inhibit thymidylate synthase derived from human leukemia K562 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMAssay Description:Ability to inhibit thymidylate synthase derived from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+3nMAssay Description:Ability to inhibit thymidylate synthase derived from human leukemia K562 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against human thymidylate synthase derived either from HeLa or KB cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+4nMAssay Description:Ability to inhibit thymidylate synthase derived from human leukemia K562 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+5nMAssay Description:Compound was evaluated for the alpha-Adrenoceptor pA2 blocking activity in vitro in rabbit thoracic aortaMore data for this Ligand-Target Pair