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Found 190 with Last Name = 'im' and Initial = 'yj'
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Inha University

Curated by ChEMBL
LigandPNGBDBM50063266(6-Nitro-2-piperazin-1-yl-quinoline | 6-nitroquipaz...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]citalopram from Sprague-Dawley rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Inha University

Curated by ChEMBL
LigandPNGBDBM50208769(2-[2-(hydroxymethyl)piperazin-1-yl]-6-nitroquinoli...)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]citalopram from Sprague-Dawley rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Inha University

Curated by ChEMBL
LigandPNGBDBM50208770(2-[2-(ethoxymethyl)piperazin-1-yl]-6-nitroquinolin...)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]citalopram from Sprague-Dawley rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Inha University

Curated by ChEMBL
LigandPNGBDBM50208771(2-[(2-methoxymethyl)piperazin-1-yl]-6-nitroquinoli...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]citalopram from Sprague-Dawley rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379308(CHEMBL2011816)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]Ghrelin from human GHSR1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Inha University

Curated by ChEMBL
LigandPNGBDBM50208772(6-nitro-2-(2-propoxymethylpiperazin-1-yl)quinoline...)
Affinity DataKi:  5.67nMAssay Description:Displacement of [3H]citalopram from Sprague-Dawley rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast cell carboxypeptidase A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281176((S)-2-Mercaptomethyl-3-phenyl-propionic acid | 2-T...)
Affinity DataKi:  7.80nMAssay Description:Compound was tested for inhibitory activity against carboxypeptidase AMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Inha University

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]citalopram from Sprague-Dawley rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Inha University

Curated by ChEMBL
LigandPNGBDBM50208768(2-[(2-butoxymethyl)piperazin-1-yl]-6-nitroquinolin...)
Affinity DataKi:  15.4nMAssay Description:Displacement of [3H]citalopram from Sprague-Dawley rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085045(5-((4-((6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-...)
Affinity DataKi:  400nMAssay Description:Binding affinity to human recombinant PPARgamma by Cheng-Prusoff equation based competitive binding TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor susceptibility gene 101 protein(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50362892(CHEMBL1946564)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of FITC-conjugated (S)-4-((S)-1-acetylpyrrolidine-2-carboxamido)-5-((2S,4R)-2-((2S,3R)-1-((S)-1-((S)-2-((S)-2-((S)-1-((S)-1-amino-4-carb...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor susceptibility gene 101 protein(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50362891(CHEMBL1946260)
Affinity DataKi:  2.70E+3nMAssay Description:Displacement of FITC-conjugated (S)-4-((S)-1-acetylpyrrolidine-2-carboxamido)-5-((2S,4R)-2-((2S,3R)-1-((S)-1-((S)-2-((S)-2-((S)-1-((S)-1-amino-4-carb...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM24566(2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidi...)
Affinity DataKi:  4.50E+3nMAssay Description:Binding affinity to human recombinant PPARalpha by Cheng-Prusoff equation based competitive binding TR-FRET assayMore data for this Ligand-Target Pair
TargetTumor susceptibility gene 101 protein(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50362890(CHEMBL1946259)
Affinity DataKi:  5.40E+3nMAssay Description:Displacement of FITC-conjugated (S)-4-((S)-1-acetylpyrrolidine-2-carboxamido)-5-((2S,4R)-2-((2S,3R)-1-((S)-1-((S)-2-((S)-2-((S)-1-((S)-1-amino-4-carb...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50548252(CHEMBL4765137)
Affinity DataKi:  6.70E+3nMAssay Description:Binding affinity to human recombinant PPARgamma by Cheng-Prusoff equation based competitive binding TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50548251(CHEMBL4797877)
Affinity DataKi:  7.00E+3nMAssay Description:Binding affinity to human recombinant PPARgamma by Cheng-Prusoff equation based competitive binding TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50548252(CHEMBL4765137)
Affinity DataKi:  8.00E+3nMAssay Description:Binding affinity to human recombinant PPARalpha by Cheng-Prusoff equation based competitive binding TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor susceptibility gene 101 protein(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50362889(CHEMBL1946129)
Affinity DataKi:  8.70E+3nMAssay Description:Displacement of FITC-conjugated (S)-4-((S)-1-acetylpyrrolidine-2-carboxamido)-5-((2S,4R)-2-((2S,3R)-1-((S)-1-((S)-2-((S)-2-((S)-1-((S)-1-amino-4-carb...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50548251(CHEMBL4797877)
Affinity DataKi:  9.50E+3nMAssay Description:Binding affinity to human recombinant PPARalpha by Cheng-Prusoff equation based competitive binding TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379328(CHEMBL2011825)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379309(CHEMBL2011826)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379312(CHEMBL2011892)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379322(CHEMBL2011832)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379320(CHEMBL2011834)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379310(CHEMBL2011894)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379334(CHEMBL2011819)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379319(CHEMBL2011835)
Affinity DataIC50:  4.10nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: <6nMAssay Description:Inhibition of CYP2D6 in human liver microsomeMore data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379314(CHEMBL2011890)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379308(CHEMBL2011816)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379335(CHEMBL2011818)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379311(CHEMBL2011893)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379308(CHEMBL2011816)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50153547(3-(2,6-Dichloro-phenyl)-5-[2-(2-oxo-piperidin-1-yl...)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379323(CHEMBL2011831)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379336(CHEMBL2011817)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379326(CHEMBL2011828)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50395775(CHEMBL2164857)
Affinity DataIC50:  15nMAssay Description:Partial agonist activity at mouse GPR142 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50158327((+/-)isobutyl 2-((4-(diethylamino)phenyl)carbamoyl...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379321(CHEMBL2011833)
Affinity DataIC50:  16.5nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379313(CHEMBL2011891)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379331(CHEMBL2011822)
Affinity DataIC50:  26nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379332(CHEMBL2011821)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379317(CHEMBL2011887)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50: <62nMAssay Description:Inhibition of CYP3A4 in human liver microsomeMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50435297(CHEMBL2393244)
Affinity DataIC50:  63nMAssay Description:Displacement of [3H]-methylspiperone from dopamine D2L receptor (unknown origin) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379329(CHEMBL2011824)
Affinity DataIC50:  79nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50435300(CHEMBL2393245)
Affinity DataIC50:  86nMAssay Description:Displacement of [3H]-methylspiperone from dopamine D2L receptor (unknown origin) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50379330(CHEMBL2011823)
Affinity DataIC50:  143nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50435299(CHEMBL2393243)
Affinity DataIC50:  147nMAssay Description:Displacement of [3H]-methylspiperone from dopamine D2L receptor (unknown origin) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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