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Found 109 with Last Name = 'ismail' and Initial = 's'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  11nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  23nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50449926(CHEMBL4167162)
Affinity DataIC50:  32nMAssay Description:Inhibition of EGFR in human MCF7 cell lysates after 24 to 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50449926(CHEMBL4167162)
Affinity DataIC50:  32nMAssay Description:Inhibition of EGFR in human MCF7 cell lysates after 24 to 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50449929(CHEMBL4169489)
Affinity DataIC50:  32nMAssay Description:Inhibition of EGFR in human MCF7 cell lysates after 24 to 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50449929(CHEMBL4169489)
Affinity DataIC50:  32nMAssay Description:Inhibition of EGFR in human MCF7 cell lysates after 24 to 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50449927(CHEMBL4166069)
Affinity DataIC50:  37nMAssay Description:Inhibition of EGFR in human MCF7 cell lysates after 24 to 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50449927(CHEMBL4166069)
Affinity DataIC50:  37nMAssay Description:Inhibition of EGFR in human MCF7 cell lysates after 24 to 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50449930(CHEMBL4170916)
Affinity DataIC50:  71nMAssay Description:Inhibition of EGFR in human MCF7 cell lysates after 24 to 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50449930(CHEMBL4170916)
Affinity DataIC50:  71nMAssay Description:Inhibition of EGFR in human MCF7 cell lysates after 24 to 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  73nMAssay Description:Inhibition of EGFR in human MCF7 cell lysates after 24 to 48 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  73nMAssay Description:Inhibition of EGFR in human MCF7 cell lysates after 24 to 48 hrs by ELISAMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM50356624(CHEMBL1910278)
Affinity DataIC50:  90nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50449928(CHEMBL4177348)
Affinity DataIC50:  98nMAssay Description:Inhibition of EGFR in human MCF7 cell lysates after 24 to 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50449928(CHEMBL4177348)
Affinity DataIC50:  98nMAssay Description:Inhibition of EGFR in human MCF7 cell lysates after 24 to 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM22372(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human 5-LOX in human peripheral blood mononuclear leukocytes assessed as inhibition of calymycin A23187-stimulated LTB4 production prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM50356616(CHEMBL1910270)
Affinity DataIC50:  300nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM22372(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 5-LOX in calcium ionophore A23187-stimulated NMRI mouse macrophage assessed as inhibition of LTC4 production preincubated for 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  400nMAssay Description:Inhibition of human recombinant COX2 expressed in insect Sf21 cells assessed as inhibition of conversion of arachidonic acid to PGE2 preincubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  420nMAssay Description:Inhibition of human 5-LOX in human peripheral blood mononuclear leukocytes assessed as inhibition of calymycin A23187-stimulated LTB4 production prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM50356618(CHEMBL1910272)
Affinity DataIC50:  500nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50464781(CHEMBL4285894)
Affinity DataIC50:  752nMAssay Description:Inhibition of recombinant human C-terminal His/N-terminal GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus infected Sf9 cells using bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM50356622(CHEMBL1910276)
Affinity DataIC50:  900nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50464782(CHEMBL4290375)
Affinity DataIC50:  901nMAssay Description:Inhibition of recombinant human C-terminal His/N-terminal GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus infected Sf9 cells using bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50464779(CHEMBL4293326)
Affinity DataIC50:  951nMAssay Description:Inhibition of recombinant human C-terminal His/N-terminal GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus infected Sf9 cells using bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Egyptian Russian University

Curated by ChEMBL
LigandPNGBDBM50142632(CHEMBL1231469)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of GST-tagged recombinant human CDK2/cyclin E expressed in insect SF-9 cells after 10 mins by scintillation counting analysis in presence ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Egyptian Russian University

Curated by ChEMBL
LigandPNGBDBM50310357(CHEMBL599552 | indigo)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of GST-tagged recombinant human CDK2/cyclin E expressed in insect SF-9 cells after 10 mins by scintillation counting analysis in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of 5-LOX in calcium ionophore A23187-stimulated NMRI mouse macrophage assessed as inhibition of LTC4 production preincubated for 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50464780(CHEMBL4292715)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of recombinant human C-terminal His/N-terminal GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus infected Sf9 cells using bi...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM50356623(CHEMBL1910277)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM50356621(CHEMBL1910275)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM50356620(CHEMBL1910274)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of COX1 in human platelets assessed as inhibition of conversion of arachidonic acid to PGE2 preincubated for 15 mins before substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM5718(2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(ben...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM50356625(CHEMBL1910279)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM50356617(CHEMBL1910271)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Ain Shams University

LigandPNGBDBM113824(1-(2-((4-Methoxyphenyl)amino)-3-oxo-3,4 dihydroqui...)
Affinity DataIC50:  1.03E+4nMT: 2°CAssay Description:Assays are performed for 15 min at 30 °C, with 50 µM of P33-ATP in a final volume of 25 µL. The assays are terminated by spotting 20 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM50356614(CHEMBL1910268)
Affinity DataIC50:  2.95E+4nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50356619(CHEMBL1910273)
Affinity DataIC50:  2.95E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM50356615(CHEMBL1910269)
Affinity DataIC50:  2.95E+4nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research

Curated by ChEMBL
LigandPNGBDBM50356619(CHEMBL1910273)
Affinity DataIC50:  3.63E+4nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50356621(CHEMBL1910275)
Affinity DataIC50:  4.79E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Ain Shams University

LigandPNGBDBM113825(2-((2-((4-Methoxyphenyl)amino)-3-oxo-3,4- dihydroq...)
Affinity DataIC50:  6.18E+4nMT: 2°CAssay Description:Assays are performed for 15 min at 30 °C, with 50 µM of P33-ATP in a final volume of 25 µL. The assays are terminated by spotting 20 &...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50356624(CHEMBL1910278)
Affinity DataIC50:  6.61E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Ain Shams University

LigandPNGBDBM113828(1-(3-Chlorophenyl)-3-(4-((6-nitroquinoxalin-2-yl)a...)
Affinity DataIC50:  8.54E+4nMT: 2°CAssay Description:Assays are performed for 15 min at 30 °C, with 50 µM of P33-ATP in a final volume of 25 µL. The assays are terminated by spotting 20 &...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50356614(CHEMBL1910268)
Affinity DataIC50:  9.33E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50356620(CHEMBL1910274)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50356618(CHEMBL1910272)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50356617(CHEMBL1910271)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50356625(CHEMBL1910279)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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