Compile Data Set for Download or QSAR
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Found 107 with Last Name = 'isshiki' and Initial = 'y'
TargetParathyroid hormone/parathyroid hormone-related peptide receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50318885(CHEMBL525610 | teriparatide)
Affinity DataIC50:  0.0800nMAssay Description:Displacement of 125I-PTH (1 to 15 residues) from human PTHR1 expressed in African green monkey COS7 cell membranes at 300 uM after 90 mins by gamma c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089536(5-[(6,6-Dimethyl-hepta-2,4-diynyl)-methyl-amino]-3...)
Affinity DataIC50:  0.140nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089557(5-[Butyl-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-amino...)
Affinity DataIC50:  0.350nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089551(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-propyl-amin...)
Affinity DataIC50:  0.680nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089540(CHEMBL32125 | Phosphoric acid 5-[(6,6-dimethyl-hep...)
Affinity DataIC50:  0.760nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089563(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089538(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-pentyl-amin...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089559(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-isopropyl-a...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50222709(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-N-(2-h...)
Affinity DataIC50:  2nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US PatentMMDB

TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089543(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-amin...)
Affinity DataIC50:  2.80nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089547(5-[(6,6-Dimethyl-hepta-2,4-diynyl)-methyl-amino]-3...)
Affinity DataIC50:  3nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104959(US8575391, G-2)
Affinity DataIC50:  7.20nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089537(5-{[4-(3,3-Dimethyl-but-1-ynyl)-benzyl]-methyl-ami...)
Affinity DataIC50:  7.20nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089560(5-(Hepta-2,4-diynyl-methyl-amino)-3,4-dihydro-1H-q...)
Affinity DataIC50:  7.90nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104951(US8575391, F-2)
Affinity DataIC50:  8.60nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50338038(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-N-(2-h...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089550(5-[(6,6-Dimethyl-hept-4-ynyl)-methyl-amino]-3,4-di...)
Affinity DataIC50:  9nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089562(3-Amino-5-[(6,6-dimethyl-hepta-2,4-diynyl)-methyl-...)
Affinity DataIC50:  12nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104949(US8575391, C-31)
Affinity DataIC50:  12nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089561(5-[((Z)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-amin...)
Affinity DataIC50:  13nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104939(US8575391, B-9)
Affinity DataIC50:  15nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089535((R)-2-Amino-3-methyl-butyric acid 5-[(6,6-dimethyl...)
Affinity DataIC50:  15nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104945(US8575391, C-10)
Affinity DataIC50:  19nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104941(US8575391, C-1)
Affinity DataIC50:  19nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104936(US8575391, B-1)
Affinity DataIC50:  21nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104938(US8575391, B-6)
Affinity DataIC50:  23nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104955(US8575391, F-6)
Affinity DataIC50:  28nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104946(US8575391, C-13)
Affinity DataIC50:  28nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104952(US8575391, F-3)
Affinity DataIC50:  29nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104940(US8575391, B-12)
Affinity DataIC50:  31nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104944(US8575391, C-8)
Affinity DataIC50:  32nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104937(US8575391, B-2)
Affinity DataIC50:  32nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104950(US8575391, F-1)
Affinity DataIC50:  35nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104953(US8575391, F-4)
Affinity DataIC50:  35nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104960(US8575391, G-3)
Affinity DataIC50:  37nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104962(US8575391, G-5)
Affinity DataIC50:  40nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104954(US8575391, F-5)
Affinity DataIC50:  43nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104956(US8575391, F-7)
Affinity DataIC50:  48nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104942(US8575391, C-6)
Affinity DataIC50:  49nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089556(5-[Benzyl-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-amin...)
Affinity DataIC50:  54nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104961(US8575391, G-4)
Affinity DataIC50:  56nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104957(US8575391, F-8)
Affinity DataIC50:  65nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104947(US8575391, C-24)
Affinity DataIC50:  68nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104948(US8575391, C-28)
Affinity DataIC50:  68nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089546(5-((E)-6,6-Dimethyl-hept-2-en-4-ynylamino)-1H-quin...)
Affinity DataIC50:  70nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM104958(US8575391, F-9)
Affinity DataIC50:  70nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089548(5-((E)-6,6-Dimethyl-hept-2-en-4-ynylamino)-3,4-dih...)
Affinity DataIC50:  71nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089546(5-((E)-6,6-Dimethyl-hept-2-en-4-ynylamino)-1H-quin...)
Affinity DataIC50:  71nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50132260(2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmetho...)
Affinity DataIC50:  130nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In DepthDetails US Patent
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