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Found 51 with Last Name = 'jacob' and Initial = 'cs'
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13614(2-(carboxymethoxy)-5-[(2S)-2-(pentylcarbamoyl)-2-[...)
Affinity DataKi:  120nM ΔG°:  -39.1kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13611(2-(carboxymethoxy)-5-[(2S)-2-[(2S)-2-(3-formamidop...)
Affinity DataKi:  250nM ΔG°:  -37.3kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13609(2-{4-[(2S)-2-[(2S)-2-(3-formamidopropanoic acid)-3...)
Affinity DataKi:  1.20E+3nM ΔG°:  -33.5kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13610(2-(carboxymethoxy)-5-[(2S)-2-(3-formamidopropanoic...)
Affinity DataKi:  2.80E+3nM ΔG°:  -31.4kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13613(2-{4-[(2S)-2-({[(1S)-1-carboxy-2-phenylethyl]carba...)
Affinity DataKi:  3.40E+3nM ΔG°:  -30.9kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13606((3S)-3-{[(1S)-1-{[(1S)-1-carbamoylpentyl]carbamoyl...)
Affinity DataKi:  5.00E+3nM ΔG°:  -30.0kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13608(2-{4-[(2S)-2-(3-formamidopropanoic acid)-2-(pentyl...)
Affinity DataKi:  1.20E+4nM ΔG°:  -27.8kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13607(3-{[(1S)-1-(pentylcarbamoyl)-2-[4-(sulfooxy)phenyl...)
Affinity DataKi:  3.00E+4nM ΔG°:  -25.6kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13612(Compound VII | methyl 2-(2-methoxy-2-oxoethoxy)-5-...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044210(7-[2-(4-methylpiperazin-1-yl)ethoxy]-8-methyl-2-mo...)
Affinity DataIC50:  850nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044219(6,8-Dimethyl-7-[2-(4-methyl-piperazin-1-yl)-ethoxy...)
Affinity DataIC50:  1.40E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044221(7-(1-tert-Butyl-1H-tetrazol-5-ylmethoxy)-8-methyl-...)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044183(7-(2-Diethylamino-ethoxy)-8-methyl-2-morpholin-4-y...)
Affinity DataIC50:  2.60E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044209(8-Methyl-7-(1-methyl-1H-tetrazol-5-ylmethoxy)-2-mo...)
Affinity DataIC50:  2.80E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044194(7-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-2-morpholin...)
Affinity DataIC50:  3.00E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044204(7-(2-Azepan-1-yl-ethoxy)-8-methyl-2-morpholin-4-yl...)
Affinity DataIC50:  3.00E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044208(8-Methyl-2-morpholin-4-yl-7-(2-piperazin-1-yl-etho...)
Affinity DataIC50:  4.00E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044216(8-Methyl-2-morpholin-4-yl-7-(2-morpholin-4-yl-etho...)
Affinity DataIC50:  4.00E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044215(8-Methyl-2-morpholin-4-yl-7-(2-pyrrolidin-1-yl-eth...)
Affinity DataIC50:  4.00E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044213(8-Ethyl-7-[2-(4-methyl-piperazin-1-yl)-ethoxy]-2-m...)
Affinity DataIC50:  4.00E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044188(8-Methyl-2-morpholin-4-yl-7-(pyridin-3-ylmethoxy)-...)
Affinity DataIC50:  4.00E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044207(8-Methyl-2-morpholin-4-yl-7-(2-thiomorpholin-4-yl-...)
Affinity DataIC50:  4.30E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044192(8-Methyl-2-morpholin-4-yl-7-(2-piperidin-1-yl-etho...)
Affinity DataIC50:  5.00E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044217(7-(2-Methoxy-ethoxy)-8-methyl-2-morpholin-4-yl-chr...)
Affinity DataIC50:  7.00E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044185(8-Methyl-2-morpholin-4-yl-7-(1-phenyl-1H-tetrazol-...)
Affinity DataIC50:  8.00E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044200(8-Allyl-7-[2-(4-methyl-piperazin-1-yl)-ethoxy]-2-m...)
Affinity DataIC50:  8.90E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044186((8-Methyl-2-morpholin-4-yl-4-oxo-4H-chromen-7-ylox...)
Affinity DataIC50:  9.00E+3nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044193(7-[2-(4-Benzyl-piperazin-1-yl)-ethoxy]-8-methyl-2-...)
Affinity DataIC50:  1.10E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044218(8-Methyl-2-morpholin-4-yl-7-(2-oxo-propoxy)-chrome...)
Affinity DataIC50:  1.20E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044184(7-(1-Cyclohexyl-1H-tetrazol-5-ylmethoxy)-8-methyl-...)
Affinity DataIC50:  1.20E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044223(7-{2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-ethoxy}-...)
Affinity DataIC50:  1.20E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044189(8-Methyl-2-morpholin-4-yl-7-(naphthalen-1-ylmethox...)
Affinity DataIC50:  1.30E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044214(7-{2-[Ethyl-(2-hydroxy-ethyl)-amino]-ethoxy}-8-met...)
Affinity DataIC50:  1.40E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044190(8-Methyl-7-(2-methylsulfanyl-ethoxy)-2-morpholin-4...)
Affinity DataIC50:  1.40E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044206(8-Methyl-2-morpholin-4-yl-7-(pyridin-2-ylmethoxy)-...)
Affinity DataIC50:  1.90E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044224(7-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-2-morpholin...)
Affinity DataIC50:  3.50E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044197(7-(benzyloxy)-8-methyl-2-morpholino-4H-chromen-4-o...)
Affinity DataIC50:  4.00E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044191(7-Methoxy-8-methyl-2-morpholin-4-yl-chromen-4-one ...)
Affinity DataIC50:  4.10E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044220(2-Morpholin-4-yl-7-(naphthalen-1-ylmethoxy)-chrome...)
Affinity DataIC50:  4.10E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044196(8-Methyl-2-morpholin-4-yl-7-(2-oxo-2-phenyl-ethoxy...)
Affinity DataIC50:  4.30E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044202(7-[2-(Ethyl-phenyl-amino)-ethoxy]-8-methyl-2-morph...)
Affinity DataIC50:  4.30E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044199(7-(2-Methoxy-benzyloxy)-8-methyl-2-morpholin-4-yl-...)
Affinity DataIC50:  4.40E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044211(7-(4-Methoxy-benzyloxy)-8-methyl-2-morpholin-4-yl-...)
Affinity DataIC50:  4.70E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044222(2-Morpholin-4-yl-7-(pyridin-2-ylmethoxy)-chromen-4...)
Affinity DataIC50:  5.30E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044205(7-Allyloxy-8-methyl-2-morpholin-4-yl-chromen-4-one...)
Affinity DataIC50:  5.80E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044195((3,8-Dimethyl-2-morpholin-4-yl-4-oxo-4H-chromen-7-...)
Affinity DataIC50:  5.90E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044198(8-Methyl-2-morpholin-4-yl-7-(naphthalen-2-ylmethox...)
Affinity DataIC50:  6.50E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044201(7-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-2-morpholin...)
Affinity DataIC50:  6.90E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044212(8-Methyl-2-morpholin-4-yl-7-[2-(4-phenyl-piperazin...)
Affinity DataIC50: >7.50E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50044203(3,8-Dimethyl-2-morpholin-4-yl-7-(naphthalen-1-ylme...)
Affinity DataIC50: >7.50E+4nMAssay Description:In vitro inhibitory activity against ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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