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Found 94 with Last Name = 'jhoti' and Initial = 'h'
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Astex

LigandPNGBDBM15131(5-indazolyl pyridine 3 | 5-{5-[(2S)-2-amino-3-(1H-...)
Affinity DataIC50:  0.5nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM12588((2R,3S)-3-({[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)...)
Affinity DataIC50:  1.40nMpH: 8.0 T: 2°CAssay Description:The cleavage of the substrate was followed by monitoring the change in fluorescence at 460 nm (excitation at 365 nm) for 25 min at room temperature o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50041945(1N-ethyl-2-benzylcarboxamido-2-[4-{2-[2-benzylcarb...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM12589((2R,3S)-3-({[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)...)
Affinity DataIC50:  3.70nMpH: 8.0 T: 2°CAssay Description:The cleavage of the substrate was followed by monitoring the change in fluorescence at 460 nm (excitation at 365 nm) for 25 min at room temperature o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50041946(1N-(2,2,2-trifluoroethyl)-2-benzylcarboxamido-2-[4...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50041944(1N-benzyl-2-[4-{3-[2-benzylcarbamoyl(benzylcarboxa...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50041949(4N-{2-[5-ethylcarbamoyl(5-methyl-3-phenyl-4-isoxaz...)
Affinity DataIC50:  5.40nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50041948(4N-{2-[5-ethylcarbamoyl(2-phenylphenylcarboxamido)...)
Affinity DataIC50:  9.90nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM50078544(3-[(3R,3aS,8aS)-1-Benzenesulfonyl-3-(4-carbamimido...)
Affinity DataIC50:  16nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM50078554((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethy...)
Affinity DataIC50:  16nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15131(5-indazolyl pyridine 3 | 5-{5-[(2S)-2-amino-3-(1H-...)
Affinity DataIC50:  27nMpH: 7.2 T: 2°CAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078554((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM50078553((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-5-(3-diethy...)
Affinity DataIC50:  50nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astex

LigandPNGBDBM13344(N-[4-Chloro-3-(3-pyridinyloxymethyl)phenyl]-3-fluo...)
Affinity DataIC50:  65nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078544(3-[(3R,3aS,8aS)-1-Benzenesulfonyl-3-(4-carbamimido...)
Affinity DataIC50:  66nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078544(3-[(3R,3aS,8aS)-1-Benzenesulfonyl-3-(4-carbamimido...)
Affinity DataIC50:  74nMAssay Description:Inhibition of activated Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus)
Astex Pharmaceuticals

LigandPNGBDBM92629((3S)-3-{[(1R)-1-(4-chloro-2-fluoro-3-phenoxyphenyl...)
Affinity DataIC50:  100nM Kd:  62nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078554((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethy...)
Affinity DataIC50:  120nMAssay Description:Inhibition of activated Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM50078552((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-5-(3-diethy...)
Affinity DataIC50:  130nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16222(CCT077373 | N-[2-({2-[(4-chlorobenzyl)oxy]ethyl}am...)
Affinity DataIC50:  170nMpH: 7.2 T: 2°CAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astex

LigandPNGBDBM13354(3-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-1-(4-chl...)
Affinity DataIC50:  196nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM12587((2R,3S)-3-{[(3-chlorophenyl)methyl]amino}-2-hydrox...)
Affinity DataIC50:  220nMpH: 8.0 T: 2°CAssay Description:The cleavage of the substrate was followed by monitoring the change in fluorescence at 460 nm (excitation at 365 nm) for 25 min at room temperature o...More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Astex

LigandPNGBDBM16222(CCT077373 | N-[2-({2-[(4-chlorobenzyl)oxy]ethyl}am...)
Affinity DataIC50:  230nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astex

LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  290nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astex

LigandPNGBDBM13353(3-fluoro-5-(morpholin-4-yl)-N-{1-[2-(pyridin-4-yl)...)
Affinity DataIC50:  340nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astex

LigandPNGBDBM13345(1-(5-tert-Butyl-2H-pyrazol-3-yl)-3-[4-chloro-3-(py...)
Affinity DataIC50:  350nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM50078556(3-[(3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-2-oxo-1-...)
Affinity DataIC50:  380nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50041947(4N-{2-[5-ethylcarbamoyl(phenylcarboxamido)methyl-2...)
Affinity DataIC50:  390nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50041950(1N-benzyl-2-[4-{3-[2-benzylcarbamoyl(benzylcarboxa...)
Affinity DataIC50:  540nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078557((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethy...)
Affinity DataIC50:  620nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astex

LigandPNGBDBM13351(3-fluoro-5-(morpholin-4-yl)-N-{3-[2-(pyridin-4-yl)...)
Affinity DataIC50:  630nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM50078557((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethy...)
Affinity DataIC50:  660nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus)
Astex Pharmaceuticals

LigandPNGBDBM92628((1R)-1-(2,4-difluoro-3-phenoxyphenyl)propan-1-amin...)
Affinity DataIC50:  1.30E+3nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astex

LigandPNGBDBM13349(2-({4-[2-(1H-indol-3-yl)ethyl]pyrimidin-2-yl}amino...)
Affinity DataIC50:  1.50E+3nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078551(CHEMBL46365 | [(3R,3aS,8aS)-3-(4-Carbamimidoyl-but...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078549((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethy...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078553((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-5-(3-diethy...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078553((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-5-(3-diethy...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of activated Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078552((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-5-(3-diethy...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM50078546((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-5-(3-diethy...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM50078551(CHEMBL46365 | [(3R,3aS,8aS)-3-(4-Carbamimidoyl-but...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078557((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethy...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of activated Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078552((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-5-(3-diethy...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of activated Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM50078560((1S,2R,4aR,6aS,6bS,7R,9aR,10aS)-2-Acetoxy-1,4a,6a,...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM50078548(3-[(3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-2-oxo-1-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM50078547(3-[(3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-2-oxo-1-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078549((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethy...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of activated Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astex

LigandPNGBDBM50078549((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethy...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078556(3-[(3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-2-oxo-1-...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078548(3-[(3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-2-oxo-1-...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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