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Found 1960 with Last Name = 'jin' and Initial = 'q'
TargetMu-type opioid receptor(MOUSE)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033531(CHEMBL333410 | N-[1-(2-Hydroxy-2-phenyl-ethyl)-3-m...)
Affinity DataKi:  0.00500nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Calcitonin receptor (1)(Homo sapiens (Human))
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50110268(CHEMBL2369895 | CSNLSTCVLGKLSQELc[DKLQK]YPRTNTGSGT...)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Calcitonin receptor (1)(Homo sapiens (Human))
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50024170(CHEMBL2369912)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Calcitonin receptor (1)(Homo sapiens (Human))
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50110272(CHEMBL2369907 | CSNLSTCVLGKLSQELc[DKLHK]YPRTNTGSGT...)
Affinity DataKi:  0.0510nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033533(CHEMBL121403 | N-[(3R,4R)-1-((S)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Calcitonin receptor (1)(Homo sapiens (Human))
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50110265(CHEMBL2369886 | CSNLSTCVLGKLSQELc[DKLHO]YPRTNTGSGT...)
Affinity DataKi:  0.0690nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Calcitonin receptor (1)(Homo sapiens (Human))
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50110275(CGNLSTCBLGTYTQDF[DKFHO]YPQTAIGVGAP-amide | CHEMBL2...)
Affinity DataKi:  0.0690nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033534(CHEMBL338510 | N-[(3S,4S)-1-((S)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033536(CHEMBL121494 | N-[(3R,4R)-1-((R)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.130nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033530(CHEMBL121211 | N-[(3S,4S)-1-((R)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.150nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033530(CHEMBL121211 | N-[(3S,4S)-1-((R)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.150nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412340(CHEMBL540359)
Affinity DataKi:  0.316nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Calcitonin receptor (1)(Homo sapiens (Human))
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50110273(CGNLSTCMLGTYTQDFc[DKFHK]FPQTAIGVGAP-amide | CHEMBL...)
Affinity DataKi:  0.560nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033537(CHEMBL121060 | N-[(3S,4R)-1-((S)-2-Hydroxy-2-pheny...)
Affinity DataKi:  2.89nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412340(CHEMBL540359)
Affinity DataKi:  3.16nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM202644(US9242957, 8)
Affinity DataKi:  5nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM202643(US9242957, 7)
Affinity DataKi:  5nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIsoform 1 of Calcitonin receptor (1)(Homo sapiens (Human))
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50110267(CGNLSTCBLGTYTQDFNKFHZYPQTAIGVGAP-amide | CHEMBL236...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033532(CHEMBL435380 | N-[(3S,4R)-1-((R)-2-Hydroxy-2-pheny...)
Affinity DataKi:  5.85nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM50328814((+/-)-6-((4-(2-(3-fluorophenethylamino)ethoxy)pyrr...)
Affinity DataKi:  7nMAssay Description:Inhibition of recombinant rat nNOS expressed in Escherichia coli using L-arginine as substrate assessed as formation of nitric oxide measured up to 6...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM50446250(CHEMBL3109188 | US9732037, Compound 9)
Affinity DataKi:  9.70nMAssay Description:Inhibition of rat recombinant nNOS overexpressed in Escherichia coli using L-arginine as substrate assessed as formation of NO-hemoglobin complex mea...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50446250(CHEMBL3109188 | US9732037, Compound 9)
Affinity DataKi:  10nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM196648(US9212144, 3 | US9242957, 65)
Affinity DataKi:  11nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM190667(US10759791, Compound 14j | nNOS inhibitor, 5)
Affinity DataKi:  13nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM50023383(CHEMBL3325611)
Affinity DataKi:  13nMAssay Description:Inhibition of rat nNOS using L-arginine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM190667(US10759791, Compound 14j | nNOS inhibitor, 5)
Affinity DataKi:  13nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM202651(US9242957, QJ-II-194)
Affinity DataKi:  13.2nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM50023384(CHEMBL3325610 | US9242957, QJ-II-203)
Affinity DataKi:  14.7nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM50023384(CHEMBL3325610 | US9242957, QJ-II-203)
Affinity DataKi:  15nMAssay Description:Inhibition of rat nNOS using L-arginine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM190667(US10759791, Compound 14j | nNOS inhibitor, 5)
Affinity DataKi:  16nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Rattus norvegicus)
Northwestern University

US Patent
LigandPNGBDBM190667(US10759791, Compound 14j | nNOS inhibitor, 5)
Affinity DataKi:  16nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  17nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  17nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Rattus norvegicus)
Northwestern University

US Patent
LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  17nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM152723(N-[3-({[(3S,5R)-5-({[3-(thiophene-2-imidamido)phen...)
Affinity DataKi:  21nMAssay Description:Inhibition of rat nNOS using L-arginine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM152720(N-[3-({[(3S,5S)-5-({[3-(thiophene-2-imidamido)phen...)
Affinity DataKi:  21.4nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM152720(N-[3-({[(3S,5S)-5-({[3-(thiophene-2-imidamido)phen...)
Affinity DataKi:  22nMAssay Description:Inhibition of rat nNOS using L-arginine substrateMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM202649(US9242957, QJ-II-195)
Affinity DataKi:  22.1nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM50093349(CHEMBL3586664 | US9951014, Name 19c)
Affinity DataKi:  24nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM50014717(CHEMBL3262026 | US10759791, Compound 8R | US995101...)
Affinity DataKi:  24nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50014717(CHEMBL3262026 | US10759791, Compound 8R | US995101...)
Affinity DataKi:  24nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM50014710(CHEMBL3262019 | US10759791, Compound 4)
Affinity DataKi:  25nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Rattus norvegicus)
Northwestern University

US Patent
LigandPNGBDBM190668(US10759791, Compound 14k | nNOS inhibitor, 6)
Affinity DataKi:  25nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM50341682(6,6'-(2,2'-(Pyridine-3,5-diyl)bis(ethane-2,1-diyl)...)
Affinity DataKi:  25nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50341682(6,6'-(2,2'-(Pyridine-3,5-diyl)bis(ethane-2,1-diyl)...)
Affinity DataKi:  25nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM190668(US10759791, Compound 14k | nNOS inhibitor, 6)
Affinity DataKi:  25nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM50446252(CHEMBL3109186 | US9732037, Compound 6)
Affinity DataKi:  26nMAssay Description:Inhibition of rat recombinant nNOS overexpressed in Escherichia coli using L-arginine as substrate assessed as formation of NO-hemoglobin complex mea...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50446252(CHEMBL3109186 | US9732037, Compound 6)
Affinity DataKi:  26nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM202653(US9242957, QJ-III-33)
Affinity DataKi:  27nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM50023386(CHEMBL3327299)
Affinity DataKi:  27nMAssay Description:Inhibition of rat nNOS using L-arginine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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