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Found 502 with Last Name = 'kang' and Initial = 'sk'
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50206821((R)-3-amino-1-(2-benzoylpiperazin-1-yl)-4-(2,4,5-t...)
Affinity DataKi:  44nMAssay Description:Inhibition of pig kidney DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50206820((R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4...)
Affinity DataKi:  56.2nMAssay Description:Inhibition of pig kidney DPP4More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM167443(US9073906, 128)
Affinity DataIC50:  0.100nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM167438(US9073906, 88)
Affinity DataIC50:  0.200nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM167440(US9073906, 122)
Affinity DataIC50:  0.400nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM167441(US9073906, 123)
Affinity DataIC50:  0.800nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM167444(US9073906, 156)
Affinity DataIC50:  1nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50337787((R)-2-(4-(((S)-3-((R)-3-amino-4-(2,4,5-trifluoroph...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant DPP4 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50384520(CHEMBL2036232)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50384522(CHEMBL2036234)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50384519(CHEMBL2036239)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50384521(CHEMBL2036233)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50384518(CHEMBL2036240)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50384519(CHEMBL2036239)
Affinity DataIC50:  1nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50337789((S)-2-(4-(((S)-3-((R)-3-amino-4-(2,4,5-trifluoroph...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant DPP4 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM167451(US9073906, 196)
Affinity DataIC50:  1.30nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334712((R,E)-3-(2-Fluoro-benzenesulfonyl)-thiazolidine-2-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50384522(CHEMBL2036234)
Affinity DataIC50:  2nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50384520(CHEMBL2036232)
Affinity DataIC50:  2nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334712((R,E)-3-(2-Fluoro-benzenesulfonyl)-thiazolidine-2-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM167437(US9073906, 69)
Affinity DataIC50:  3nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334708((E)-3-[(2-Fluorophenyl)sulfonyl]-N-[5-(aminocarbon...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50337785(2-(4-((3-((R)-3-amino-4-(2,4,5-trifluorophenyl)but...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant DPP4 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334708((E)-3-[(2-Fluorophenyl)sulfonyl]-N-[5-(aminocarbon...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50334709(3-(3-Fluoro-benzenesulfonyl)-thiazolidine-2-carbox...)
Affinity DataIC50:  4nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50384518(CHEMBL2036240)
Affinity DataIC50:  4nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM167449(US9073906, 183)
Affinity DataIC50:  4.80nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM167447(US9073906, 176)
Affinity DataIC50:  5nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM167448(US9073906, 177)
Affinity DataIC50:  5nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334704(3-(3,4-Dichloro-benzenesulfonyl)-thiazolidine-2-ca...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50384525(CHEMBL2036237)
Affinity DataIC50:  5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50384524(CHEMBL2036236)
Affinity DataIC50:  5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50337779(2-(4-((3-((R)-3-amino-4-(2,4,5-trifluorophenyl)but...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant DPP4 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50334705(3-Benzenesulfonyl-thiazolidine-2-carboxylic acid(5...)
Affinity DataIC50:  6nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334706(3-(Toluene-4-sulfonyl)-thiazolidine-2-carboxylic a...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50384523(CHEMBL2036235)
Affinity DataIC50:  8nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334714((R)-1-(2-Fluoro-benzenesulfonyl)-pyrrolidine-2-car...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50337791((R)-2-(4-(((R)-3-((R)-3-amino-4-(2,4,5-trifluoroph...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant DPP4 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334701(3-(3,4-Dichloro-benzenesulfonyl)-thiazolidine-2-ca...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334699(3-(2-Fluoro-benzenesulfonyl)-thiazolidine-2-carbox...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334700(3-(4-Chloro-benzenesulfonyl)-thiazolidine-2-carbox...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334694(3-Benzenesulfonyl-thiazolidine-2-carboxylic acid a...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334710(3-(4-Fluoro-benzenesulfonyl)-thiazolidine-2-carbox...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334709(3-(3-Fluoro-benzenesulfonyl)-thiazolidine-2-carbox...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50384529(CHEMBL2036424 | US9073906, 2)
Affinity DataIC50:  12nMAssay Description:The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334711((S)-3-(2-Fluoro-benzenesulfonyl)-thiazolidine-2-ca...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50384529(CHEMBL2036424 | US9073906, 2)
Affinity DataIC50:  12nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50334711((S)-3-(2-Fluoro-benzenesulfonyl)-thiazolidine-2-ca...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50337793((S)-2-(4-(((R)-3-((R)-3-amino-4-(2,4,5-trifluoroph...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant DPP4 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50337783(2-(4-((3-((R)-3-amino-4-(2,4,5-trifluorophenyl)but...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant DPP4 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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