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Found 514 with Last Name = 'kawai' and Initial = 'y'
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM126083(US8779142, 102)
Affinity DataKi:  21nMAssay Description:Binding affinity to human HSP90-beta by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM126083(US8779142, 102)
Affinity DataKi:  35nMAssay Description:Inhibition of FITC-GDA binding to human HSP90-alpha incubated for 2 hrs followed by FITC-GDA addition and measured after 5 hrs by fluorescence polari...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50582399(CHEMBL5094983)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of FITC-GDA binding to human HSP90-alpha incubated for 2 hrs followed by FITC-GDA addition and measured after 5 hrs by fluorescence polari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50582399(CHEMBL5094983)
Affinity DataKi:  1.70E+4nMAssay Description:Binding affinity to human HSP90-beta by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndoplasmin(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM126083(US8779142, 102)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to GRP94 (unknown origin) by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein 75 kDa, mitochondrial(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM126083(US8779142, 102)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to TRAP1 (unknown origin) by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndoplasmin(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50582399(CHEMBL5094983)
Affinity DataKi: >3.00E+5nMAssay Description:Binding affinity to GRP94 (unknown origin) by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein 75 kDa, mitochondrial(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50582399(CHEMBL5094983)
Affinity DataKi: >3.00E+5nMAssay Description:Binding affinity to TRAP1 (unknown origin) by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309489(US9603833, Example 111)
Affinity DataIC50:  0.400nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Homo sapiens (Human))
R-Tech Ueno

US Patent
LigandPNGBDBM309489(US9603833, Example 111)
Affinity DataIC50:  0.5nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
R-Tech Ueno

US Patent
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  0.5nMAssay Description:The compounds of the present invention obtained in the Production Examples were examined for the inhibitory effect on human monoamineoxydase enzymes ...More data for this Ligand-Target Pair
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309497(US9603833, Example 120)
Affinity DataIC50:  0.600nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309491(US9603833, Example 113)
Affinity DataIC50:  0.700nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309490(US9603833, Example 112)
Affinity DataIC50:  0.700nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Homo sapiens (Human))
R-Tech Ueno

US Patent
LigandPNGBDBM309490(US9603833, Example 112)
Affinity DataIC50:  0.700nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D](Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM50576728(CHEMBL4849611 | US20230348495, Example 7)
Affinity DataIC50:  0.700nMAssay Description:For the measurement of the inhibitory activity of compounds on GDP-GTP exchange rate of recombinant KRAS G12D, BODIPY FL GDP-bound KRAS G12D protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D](Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM50576730(CHEMBL4869200 | US20230348495, Example 9)
Affinity DataIC50:  0.700nMAssay Description:For the measurement of the inhibitory activity of compounds on GDP-GTP exchange rate of recombinant KRAS G12D, BODIPY FL GDP-bound KRAS G12D protein ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309486(US9603833, Example 108)
Affinity DataIC50:  0.800nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D](Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM633148(US20230348495, Example 1)
Affinity DataIC50:  0.800nMAssay Description:For the measurement of the inhibitory activity of compounds on GDP-GTP exchange rate of recombinant KRAS G12D, BODIPY FL GDP-bound KRAS G12D protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309479(US9603833, Example 92)
Affinity DataIC50:  0.800nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309477(US9603833, Example 89)
Affinity DataIC50:  0.900nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309476(US9603833, Example 88)
Affinity DataIC50:  0.900nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D](Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM50576729(CHEMBL4876274 | US20230348495, Example 8)
Affinity DataIC50:  0.900nMAssay Description:For the measurement of the inhibitory activity of compounds on GDP-GTP exchange rate of recombinant KRAS G12D, BODIPY FL GDP-bound KRAS G12D protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Homo sapiens (Human))
R-Tech Ueno

US Patent
LigandPNGBDBM309491(US9603833, Example 113)
Affinity DataIC50:  0.900nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Homo sapiens (Human))
R-Tech Ueno

US Patent
LigandPNGBDBM309486(US9603833, Example 108)
Affinity DataIC50:  0.900nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309474(US9603833, Example 86)
Affinity DataIC50:  1nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309459(US9603833, Example 12)
Affinity DataIC50:  1.10nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309492(US9603833, Example 114)
Affinity DataIC50:  1.20nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309464(US9603833, Example 45)
Affinity DataIC50:  1.20nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D](Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM50576726(CHEMBL4872714 | US20230348495, Example 3)
Affinity DataIC50:  1.20nMAssay Description:For the measurement of the inhibitory activity of compounds on GDP-GTP exchange rate of recombinant KRAS G12D, BODIPY FL GDP-bound KRAS G12D protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309470(US9603833, Example 70)
Affinity DataIC50:  1.30nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309478(US9603833, Example 90)
Affinity DataIC50:  1.40nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309475(US9603833, Example 87)
Affinity DataIC50:  1.40nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309487(US9603833, Example 109)
Affinity DataIC50:  1.40nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D](Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM633208(US20230348495, Example 11)
Affinity DataIC50:  1.40nMAssay Description:For the measurement of the inhibitory activity of compounds on GDP-GTP exchange rate of recombinant KRAS G12D, BODIPY FL GDP-bound KRAS G12D protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D](Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM50576725(CHEMBL4875572 | US20230348495, Example 2)
Affinity DataIC50:  1.5nMAssay Description:For the measurement of the inhibitory activity of compounds on GDP-GTP exchange rate of recombinant KRAS G12D, BODIPY FL GDP-bound KRAS G12D protein ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGTPase KRas [G12D](Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM633194(US20230348495, Example 4)
Affinity DataIC50:  1.5nMAssay Description:For the measurement of the inhibitory activity of compounds on GDP-GTP exchange rate of recombinant KRAS G12D, BODIPY FL GDP-bound KRAS G12D protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D](Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM633207(US20230348495, Example 10)
Affinity DataIC50:  1.5nMAssay Description:For the measurement of the inhibitory activity of compounds on GDP-GTP exchange rate of recombinant KRAS G12D, BODIPY FL GDP-bound KRAS G12D protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309498(US9603833, Example 121)
Affinity DataIC50:  1.60nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309488(US9603833, Example 110)
Affinity DataIC50:  1.60nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309473(US9603833, Example 85)
Affinity DataIC50:  1.90nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Homo sapiens (Human))
R-Tech Ueno

US Patent
LigandPNGBDBM309492(US9603833, Example 114)
Affinity DataIC50:  2nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309482(US9603833, Example 101)
Affinity DataIC50:  2.10nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Homo sapiens (Human))
R-Tech Ueno

US Patent
LigandPNGBDBM309498(US9603833, Example 121)
Affinity DataIC50:  2.20nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309461(US9603833, Example 30)
Affinity DataIC50:  2.20nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309481(US9603833, Example 99)
Affinity DataIC50:  2.5nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
R-Tech Ueno

US Patent
LigandPNGBDBM309495(US9603833, Example 117)
Affinity DataIC50:  2.70nMAssay Description:The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM376962(US10329300, Example 50 | US11696917, Example 50 | ...)
Affinity DataIC50:  2.90nMAssay Description:For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM376962(US10329300, Example 50 | US11696917, Example 50 | ...)
Affinity DataIC50:  2.90nMAssay Description:For setting the conditions for the method for measuring the in vitro inhibitory activity of a compound against HER2-phosphorylating activity, Profile...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D](Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM633226(US20230348495, Example 20)
Affinity DataIC50:  3nMAssay Description:For the measurement of the inhibitory activity of compounds on GDP-GTP exchange rate of recombinant KRAS G12D, BODIPY FL GDP-bound KRAS G12D protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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