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Found 1610 with Last Name = 'kawamura' and Initial = 'm'
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237869((+/-)-2-(1,3-bis(2-(2-methylpyrrolidin-1-yl)ethyl)...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237870(2-(1,3-bis(2-((S)-2-methylpyrrolidin-1-yl)ethyl)im...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237874((+/-)-2-(1-(2-(2-methylpyrrolidin-1-yl)ethyl)-3-(2...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237872(2-(3-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)-1-(2-(...)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237870(2-(1,3-bis(2-((S)-2-methylpyrrolidin-1-yl)ethyl)im...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237869((+/-)-2-(1,3-bis(2-(2-methylpyrrolidin-1-yl)ethyl)...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237874((+/-)-2-(1-(2-(2-methylpyrrolidin-1-yl)ethyl)-3-(2...)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237872(2-(3-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)-1-(2-(...)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237875(2-(1,3-bis(2-((R)-2-methylpyrrolidin-1-yl)ethyl)im...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  1.26nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237875(2-(1,3-bis(2-((R)-2-methylpyrrolidin-1-yl)ethyl)im...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237878(2-(1,3-bis(3-(piperidin-1-yl)propyl)imidazolidin-2...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237878(2-(1,3-bis(3-(piperidin-1-yl)propyl)imidazolidin-2...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220612(3-amino-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl)m...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220606(CHEMBL249093 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclo...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220592(CHEMBL248875 | N-(3-phenethoxybenzyl)-4-hydroxyben...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220611(6-hydroxy-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220608(2-oxo-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl)met...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237871(2-(1-(2-(piperidin-1-yl)ethyl)-3-(3-(piperidin-1-y...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237871(2-(1-(2-(piperidin-1-yl)ethyl)-3-(3-(piperidin-1-y...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220603(4-hydroxy-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220602(CHEMBL249307 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclo...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50231646(3-(6-Chloro-naphthalene-2-sulfonyl)-1-[4-(2-hydrox...)
Affinity DataKi:  8nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220595(3,5-difluoro-4-hydroxy-N-(((1s,4s)-4-(2-phenoxyeth...)
Affinity DataKi:  8.5nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237873(2-(1-(4-(piperidin-1-yl)butyl)-3-(2-(piperidin-1-y...)
Affinity DataKi:  8.60nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220591(CHEMBL249909 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclo...)
Affinity DataKi:  8.90nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220598(6-oxo-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl)met...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220599(3,5-difluoro-4-hydroxy-N-(((1s,4s)-4-(phenoxymethy...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220610(CHEMBL250108 | N-(((1s,4s)-4-(phenoxymethyl)cycloh...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220601(CHEMBL400917 | N-benzyl-3-{[(4-hydroxybenzoyl)amin...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220597(CHEMBL398356 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclo...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50372526(CHEMBL261646)
Affinity DataKi:  15nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237873(2-(1-(4-(piperidin-1-yl)butyl)-3-(2-(piperidin-1-y...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220607(2-oxo-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)meth...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220590(4-hydroxy-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237879(2-(1,3-bis(2-(piperidin-1-yl)ethyl)imidazolidin-2-...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237876(2-(1-(naphthalen-1-ylmethyl)-3-(3-(piperidin-1-yl)...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237879(2-(1,3-bis(2-(piperidin-1-yl)ethyl)imidazolidin-2-...)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237877(2-(1-(2-((3-(dimethylamino)propyl)(ethyl)amino)eth...)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237877(2-(1-(2-((3-(dimethylamino)propyl)(ethyl)amino)eth...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220600(CHEMBL398357 | N-(((1s,4s)-4-(phenoxymethyl)cycloh...)
Affinity DataKi:  84nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220594(3,5-dimethyl-N-(((1s,4s)-4-(phenoxymethyl)cyclohex...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220605(6-oxo-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)meth...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220593(6-hydroxy-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220609(3,5-dimethyl-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohe...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220604(CHEMBL249297 | N-(((1s,4s)-4-(phenoxymethyl)cycloh...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220596(3-amino-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)me...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237876(2-(1-(naphthalen-1-ylmethyl)-3-(3-(piperidin-1-yl)...)
Affinity DataKi:  690nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50231646(3-(6-Chloro-naphthalene-2-sulfonyl)-1-[4-(2-hydrox...)
Affinity DataKi:  960nMAssay Description:Inhibition of human thrombin after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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