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Found 35 with Last Name = 'kepler' and Initial = 'j'
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  0.0540nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222089((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5-et...)
Affinity DataIC50:  0.340nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222091((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5,15...)
Affinity DataIC50:  0.590nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222086((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Affinity DataIC50:  0.630nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222092((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Affinity DataIC50:  0.980nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222088((3S,10'S,11'S,15'S,17'R)-5-ethyl-17'-(3-fluoro-4-m...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222087((3S,10'S,11'S,15'S,17'R)-17'-(3-fluoro-4-methoxyph...)
Affinity DataIC50:  4.60nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1(Rattus norvegicus (rat))
Research Triangle Institute

US Patent
LigandPNGBDBM104978(US8575375, C-8)
Affinity DataIC50:  9.79nMAssay Description:[35S]TBPS binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid (GABA) B receptor 1(Rattus norvegicus (rat))
Research Triangle Institute

US Patent
LigandPNGBDBM50055912((3alpha,5alpha)-3-hydroxypregnan-20-one) | 1-((3R,...)
Affinity DataIC50:  12.6nMAssay Description:[35S]TBPS binding assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50364466(CHEMBL1950695)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of dexamethasone-induced transcription at GRE after 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid (GABA) B receptor 1(Rattus norvegicus (rat))
Research Triangle Institute

US Patent
LigandPNGBDBM104975(US8575375, A2-A)
Affinity DataIC50:  13nMAssay Description:[35S]TBPS binding assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid (GABA) B receptor 1(Rattus norvegicus (rat))
Research Triangle Institute

US Patent
LigandPNGBDBM104976(US8575375, A2-B)
Affinity DataIC50:  17.9nMAssay Description:[35S]TBPS binding assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222085((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50364465(CHEMBL1950694)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of dexamethasone-induced transcription at GRE after 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222092((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid (GABA) B receptor 1(Rattus norvegicus (rat))
Research Triangle Institute

US Patent
LigandPNGBDBM104977(US8575375, B-5)
Affinity DataIC50:  32nMAssay Description:[35S]TBPS binding assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50364465(CHEMBL1950694)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50364468(CHEMBL1950698)
Affinity DataIC50:  41nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50364464(CHEMBL1950693)
Affinity DataIC50:  45nMAssay Description:Antagonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of dexamethasone-induced transcription at GRE after 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50364469(CHEMBL1950696)
Affinity DataIC50:  46nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50364468(CHEMBL1950698)
Affinity DataIC50:  60nMAssay Description:Antagonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of dexamethasone-induced transcription at GRE after 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50364467(CHEMBL1950697)
Affinity DataIC50:  61nMAssay Description:Antagonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of dexamethasone-induced transcription at GRE after 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50364466(CHEMBL1950695)
Affinity DataIC50:  65nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222090((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-15'-...)
Affinity DataIC50:  82nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222086((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Affinity DataIC50:  82nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50364467(CHEMBL1950697)
Affinity DataIC50:  85nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50364464(CHEMBL1950693)
Affinity DataIC50:  101nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50364469(CHEMBL1950696)
Affinity DataIC50:  142nMAssay Description:Antagonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of dexamethasone-induced transcription at GRE after 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222089((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5-et...)
Affinity DataIC50:  210nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222091((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5,15...)
Affinity DataIC50:  460nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222085((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Affinity DataIC50:  540nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222087((3S,10'S,11'S,15'S,17'R)-17'-(3-fluoro-4-methoxyph...)
Affinity DataIC50:  660nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222088((3S,10'S,11'S,15'S,17'R)-5-ethyl-17'-(3-fluoro-4-m...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222090((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-15'-...)
Affinity DataIC50:  1.40E+4nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed